Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 32261..32886 Replicon plasmid unnamed
Accession NZ_CP015380
Organism Hafnia alvei strain HUMV-5920

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag A6V27_RS20760 Protein ID WP_040047086.1
Coordinates 32261..32659 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag A6V27_RS20765 Protein ID WP_040047085.1
Coordinates 32659..32886 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6V27_RS20735 27759..28286 + 528 WP_046448642.1 single-stranded DNA-binding protein -
A6V27_RS20740 28473..28772 + 300 WP_063587662.1 hypothetical protein -
A6V27_RS20745 29027..29317 - 291 WP_046448644.1 type II toxin-antitoxin system RelE/ParE family toxin -
A6V27_RS20750 29307..29561 - 255 WP_046448645.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
A6V27_RS21310 29697..29930 - 234 Protein_22 tyrosine-type recombinase/integrase -
A6V27_RS21820 30333..30470 - 138 WP_155403049.1 hypothetical protein -
A6V27_RS20755 30704..32254 + 1551 WP_063587663.1 type IV secretion system DNA-binding domain-containing protein -
A6V27_RS20760 32261..32659 - 399 WP_040047086.1 tRNA(fMet)-specific endonuclease VapC Toxin
A6V27_RS20765 32659..32886 - 228 WP_040047085.1 antitoxin Antitoxin
A6V27_RS20770 32999..33328 + 330 WP_063587664.1 relaxase domain-containing protein -
A6V27_RS20775 33306..35588 + 2283 WP_081250340.1 AAA family ATPase -
A6V27_RS21315 36258..37268 - 1011 Protein_29 IS110 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..87576 87576


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14868.22 Da        Isoelectric Point: 7.6670

>T62966 WP_040047086.1 NZ_CP015380:c32659-32261 [Hafnia alvei]
MLKYMLDTNICIFTIKNKPESVREKFNCHSHQLCISSVTLMELIYGAEKSTAPERNLAIIEGFTARLSVLNYDCYAAAHS
GQIRAELARFGKPIGPYDLMIAGHARSCGLIVVTNNTREFERVSGLRLEDWI

Download         Length: 399 bp

>T62966 NZ_CP015380:c32659-32261 [Hafnia alvei]
ATGCTCAAATACATGCTTGATACCAACATTTGTATTTTCACCATTAAAAATAAACCGGAGTCTGTACGCGAAAAATTCAA
TTGCCACAGTCATCAACTTTGTATTAGTTCAGTGACTTTAATGGAGCTCATTTATGGTGCGGAAAAAAGCACCGCACCTG
AGCGTAACTTAGCCATCATTGAAGGTTTTACGGCACGTTTATCCGTACTTAATTACGACTGCTATGCAGCCGCACATTCT
GGTCAAATTAGGGCTGAGCTAGCGCGCTTTGGTAAACCTATTGGCCCCTATGACCTGATGATTGCTGGTCATGCTCGGAG
TTGTGGACTTATCGTTGTCACTAACAATACACGTGAGTTTGAGCGTGTTTCTGGTCTGCGGCTGGAAGATTGGATCTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8552.61 Da        Isoelectric Point: 4.3228

>AT62966 WP_040047085.1 NZ_CP015380:c32886-32659 [Hafnia alvei]
METSVFLSNRSQAVRLPKAVALPEDVKRVEIIAIGRTRLITPAGESWDSWFEGNSVTDDFMSEREQPEMQEREAL

Download         Length: 228 bp

>AT62966 NZ_CP015380:c32886-32659 [Hafnia alvei]
ATGGAAACTAGCGTATTCCTCAGCAATCGCAGTCAGGCTGTTCGTTTACCCAAAGCCGTGGCACTACCCGAAGATGTCAA
ACGTGTAGAGATCATTGCTATAGGTCGAACTCGCTTAATTACGCCAGCCGGAGAATCATGGGATAGTTGGTTTGAGGGAA
ATTCGGTTACAGATGACTTTATGTCTGAGCGCGAACAACCTGAAATGCAAGAGCGTGAGGCCCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References