Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 29027..29561 Replicon plasmid unnamed
Accession NZ_CP015380
Organism Hafnia alvei strain HUMV-5920

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag A6V27_RS20745 Protein ID WP_046448644.1
Coordinates 29027..29317 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag A6V27_RS20750 Protein ID WP_046448645.1
Coordinates 29307..29561 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6V27_RS20720 24160..24957 + 798 WP_145916014.1 YadA-like family protein -
A6V27_RS20725 25135..25698 + 564 WP_040047314.1 hypothetical protein -
A6V27_RS20730 25835..26605 + 771 WP_063587661.1 EAL domain-containing protein -
A6V27_RS20735 27759..28286 + 528 WP_046448642.1 single-stranded DNA-binding protein -
A6V27_RS20740 28473..28772 + 300 WP_063587662.1 hypothetical protein -
A6V27_RS20745 29027..29317 - 291 WP_046448644.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A6V27_RS20750 29307..29561 - 255 WP_046448645.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
A6V27_RS21310 29697..29930 - 234 Protein_22 tyrosine-type recombinase/integrase -
A6V27_RS21820 30333..30470 - 138 WP_155403049.1 hypothetical protein -
A6V27_RS20755 30704..32254 + 1551 WP_063587663.1 type IV secretion system DNA-binding domain-containing protein -
A6V27_RS20760 32261..32659 - 399 WP_040047086.1 tRNA(fMet)-specific endonuclease VapC -
A6V27_RS20765 32659..32886 - 228 WP_040047085.1 antitoxin -
A6V27_RS20770 32999..33328 + 330 WP_063587664.1 relaxase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..87576 87576


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-47)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11408.43 Da        Isoelectric Point: 10.2697

>T62965 WP_046448644.1 NZ_CP015380:c29317-29027 [Hafnia alvei]
MTFSIEFDERAFKEWNKLEKTVREQFKKKLKKLQQNPYVESARLHGDLAGCFKIKLRASGFRLIYKVIDDEIVIWVIAVG
KREAEKAYEMAQKRLL

Download         Length: 291 bp

>T62965 NZ_CP015380:c29317-29027 [Hafnia alvei]
ATGACTTTTAGTATTGAATTTGACGAAAGGGCTTTCAAGGAATGGAATAAGCTTGAAAAAACTGTCCGCGAACAATTCAA
AAAGAAGCTAAAAAAACTGCAGCAAAACCCTTACGTTGAATCAGCGAGATTGCATGGAGATCTCGCTGGCTGCTTTAAAA
TAAAGCTAAGAGCATCAGGCTTTCGTCTAATTTACAAGGTTATCGATGATGAGATAGTTATATGGGTGATTGCTGTCGGC
AAACGAGAAGCCGAGAAGGCCTATGAGATGGCTCAAAAGCGGCTTTTATAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9746.10 Da        Isoelectric Point: 4.4247

>AT62965 WP_046448645.1 NZ_CP015380:c29561-29307 [Hafnia alvei]
MSTIQIRVDDELKKDAYQAFEKLNLSPSDALRLFLRYVVENEKLPFAEVSVMVSEDDEDADILAVVRERMKNPGKRIRVN
VDDF

Download         Length: 255 bp

>AT62965 NZ_CP015380:c29561-29307 [Hafnia alvei]
ATGAGCACAATCCAAATCCGCGTAGATGACGAGCTGAAAAAAGATGCCTATCAGGCCTTTGAAAAACTGAATCTGTCTCC
TTCTGATGCACTTCGTCTGTTCCTGCGATATGTCGTAGAGAACGAAAAACTGCCTTTTGCTGAAGTCTCAGTGATGGTGA
GTGAAGATGATGAGGATGCTGATATCTTGGCGGTCGTCAGAGAAAGGATGAAAAATCCGGGCAAACGGATCAGGGTTAAC
GTTGATGACTTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References