Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1046153..1046934 Replicon chromosome
Accession NZ_CP015379
Organism Hafnia alvei strain HUMV-5920

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag A6V27_RS04855 Protein ID WP_063585947.1
Coordinates 1046153..1046644 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID -
Locus tag A6V27_RS04860 Protein ID WP_063585948.1
Coordinates 1046641..1046934 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6V27_RS04830 1041907..1042257 + 351 WP_040046353.1 divalent cation tolerance protein CutA -
A6V27_RS04835 1042233..1043927 + 1695 WP_063585945.1 protein-disulfide reductase DsbD -
A6V27_RS04840 1043987..1044562 + 576 WP_063585946.1 transcriptional regulator -
A6V27_RS04845 1044659..1045303 - 645 WP_040046356.1 YfdX family protein -
A6V27_RS04855 1046153..1046644 - 492 WP_063585947.1 GNAT family N-acetyltransferase Toxin
A6V27_RS04860 1046641..1046934 - 294 WP_063585948.1 DUF1778 domain-containing protein Antitoxin
A6V27_RS04865 1047059..1047967 - 909 WP_103008906.1 LysR family transcriptional regulator -
A6V27_RS04870 1048071..1048574 + 504 WP_025798645.1 phenolic acid decarboxylase -
A6V27_RS04875 1048638..1050056 - 1419 WP_063585950.1 aldehyde dehydrogenase family protein -
A6V27_RS04880 1050179..1051087 + 909 WP_063585951.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(74-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17862.76 Da        Isoelectric Point: 7.7299

>T62952 WP_063585947.1 NZ_CP015379:c1046644-1046153 [Hafnia alvei]
MISAPEPLHARHDVNTFCCGVDSMDNWLRLRAIKNQITGASRTFVCCDDNARVMAYYSLASSAVMSNSAPGRFRRNMPDP
IPVVVLGRLAVDKSLHSKGVGRALLRDAGLRVIQVAETIGIRGMLVHALSDEAREFYLRVGFEPSPMDPMMLMVTLGDLE
GSV

Download         Length: 492 bp

>T62952 NZ_CP015379:c1046644-1046153 [Hafnia alvei]
ATGATCTCCGCTCCTGAACCGCTTCACGCCAGACATGATGTTAATACATTTTGCTGTGGCGTGGATTCTATGGATAACTG
GCTCAGGCTGCGGGCGATAAAAAATCAGATAACCGGAGCATCTCGTACCTTTGTGTGCTGCGACGATAATGCCCGAGTTA
TGGCGTATTACTCATTAGCGTCCAGCGCGGTGATGAGCAACTCTGCCCCCGGCCGCTTTCGCCGTAACATGCCCGACCCG
ATCCCTGTCGTGGTGTTAGGGCGACTGGCGGTAGATAAATCACTGCACAGCAAGGGCGTTGGCCGTGCGTTATTGCGTGA
TGCGGGGTTACGTGTGATTCAGGTGGCGGAAACTATTGGCATTCGTGGCATGTTGGTTCACGCATTATCTGATGAAGCGC
GGGAATTTTATCTGCGCGTGGGATTTGAGCCATCGCCAATGGATCCGATGATGCTGATGGTGACGCTGGGGGATTTGGAG
GGGAGTGTTTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10949.65 Da        Isoelectric Point: 10.1968

>AT62952 WP_063585948.1 NZ_CP015379:c1046934-1046641 [Hafnia alvei]
MPMTNSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPDAYQAFLTRLDEAPAPN
AALRKTMQTPAPWEQKK

Download         Length: 294 bp

>AT62952 NZ_CP015379:c1046934-1046641 [Hafnia alvei]
ATGCCAATGACAAATAGCATGTCCATTAAACGCGAAACATTGAACCTTCGCATTAAACCCGCTGAACGCGACCTTATCGA
TCGGGCGGCAAAGGCCAGAGGAAAAAATCGCACTGATTTTGTTCTGGAAGCTGCACGGGCGGCGGCTGAGGAAGCGTTGA
TCGAACAGCGTATTATCATGGCCGATCCTGATGCTTATCAGGCGTTTTTGACTCGTCTGGATGAAGCGCCTGCACCAAAC
GCCGCACTGCGTAAAACAATGCAAACTCCCGCGCCGTGGGAGCAGAAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References