Detailed information of TA system TA062948

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 895967..896868
• Replicon: chromosome
• Accession: NZ_CP015379
• Organism: Hafnia alvei strain HUMV-5920

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: A6V27_RS04085
• Protein ID: WP_063585891.1
• Coordinates: 895967..896425 (-)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: A6V27_RS04090
• Protein ID: WP_063585892.1
• Coordinates: 896422..896868 (-)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A6V27_RS04065	891503..892081	-	579	WP_063585889.1	hypothetical protein	-
A6V27_RS04070	892370..892861	+	492	WP_081250255.1	hypothetical protein	-
A6V27_RS04075	893215..895353	+	2139	WP_040046268.1	anaerobic ribonucleoside-triphosphate reductase	-
A6V27_RS04080	895497..895961	+	465	WP_040046269.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
A6V27_RS04085	895967..896425	-	459	WP_063585891.1	RES family NAD+ phosphorylase	Toxin
A6V27_RS04090	896422..896868	-	447	WP_063585892.1	DUF2384 domain-containing protein	Antitoxin
A6V27_RS04095	897228..898028	+	801	WP_040046272.1	phosphonate ABC transporter ATP-binding protein	-
A6V27_RS04100	898064..899080	+	1017	WP_040046273.1	phosphonate ABC transporter substrate-binding protein	-
A6V27_RS04105	899156..899950	+	795	WP_063585893.1	phosphonate ABC transporter, permease protein PhnE	-
A6V27_RS04110	899971..900696	+	726	WP_046359406.1	phosphonate metabolism transcriptional regulator PhnF	-
A6V27_RS04115	900697..901170	+	474	WP_063585894.1	phosphonate C-P lyase system protein PhnG	-
A6V27_RS04120	901170..901769	+	600	WP_063585895.1	phosphonate C-P lyase system protein PhnH	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (4-139)

Antitoxin

• Antitoxin Xre (16-148)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 17081.61 Da
• Isoelectric Point: 6.7199

>T62948 WP_063585891.1 NZ_CP015379:c896425-895967 [Hafnia alvei]
MMGYRIVKTKFANSAFTGQGAKQFGGRWNRMGSPMVYLASSISLAMLECLVHLESARLTEFYSLFSIEIDDRDISSLDVS
VLPAQWRQDEISSVTADMGSQWIASKVSVGLRVPSVIVPQENNLLLNPQHPKFERYLTTVAEIPHAFDERLK

Nucleotide

• Length: 459 bp

>T62948 NZ_CP015379:c896425-895967 [Hafnia alvei]
ATGATGGGCTATCGCATTGTTAAAACCAAATTTGCAAACAGCGCATTCACGGGGCAGGGAGCAAAGCAGTTTGGCGGGCG
CTGGAACCGCATGGGTAGCCCAATGGTGTATCTGGCCAGTTCTATCTCGCTTGCGATGCTGGAATGTTTGGTTCACCTCG
AAAGCGCGCGGCTAACCGAGTTTTACTCGCTTTTTTCGATAGAAATTGACGACCGTGATATTAGCTCGCTGGATGTCAGC
GTATTGCCTGCTCAGTGGCGTCAGGATGAGATCTCATCGGTAACCGCCGATATGGGGTCACAGTGGATAGCATCGAAGGT
ATCCGTAGGATTACGGGTGCCTTCGGTGATTGTGCCACAGGAAAATAATCTCTTACTGAATCCGCAGCATCCAAAGTTTG
AACGCTACCTAACTACGGTAGCTGAAATACCGCATGCTTTTGATGAGCGGCTGAAATGA

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16317.70 Da
• Isoelectric Point: 6.8829

>AT62948 WP_063585892.1 NZ_CP015379:c896868-896422 [Hafnia alvei]
MRMFTPTQQRDESTLWRVVSFPPEGSIQLLELLKQGLPTDVIESIHQWTGINKADIVQIAGISGRQVSRRKNGPKTLSPE
QSESIARLVRVMNAAIALFEDDKEQAIHWLTHPVRALGETAPASLISTESGAIAVLNLIGRLEHGVFS

Nucleotide

• Length: 447 bp

>AT62948 NZ_CP015379:c896868-896422 [Hafnia alvei]
ATGCGTATGTTCACACCAACTCAGCAGCGGGATGAAAGCACACTTTGGCGCGTAGTGAGTTTTCCACCAGAAGGTAGTAT
TCAGTTGCTTGAGTTGCTTAAACAGGGATTACCTACTGACGTGATTGAAAGTATTCACCAATGGACGGGGATTAATAAGG
CCGATATCGTCCAGATCGCGGGGATCAGCGGTCGTCAGGTTTCTCGTCGAAAGAATGGGCCTAAAACGTTATCGCCCGAG
CAGAGTGAAAGTATTGCTCGTTTGGTGCGGGTGATGAACGCGGCGATTGCACTTTTTGAGGATGATAAAGAGCAGGCTAT
CCACTGGCTAACACATCCTGTGCGTGCTTTAGGGGAGACTGCCCCTGCGAGCCTTATCAGCACGGAGAGTGGAGCTATTG
CGGTATTAAACCTGATTGGGCGCTTGGAGCACGGTGTATTCTCATGA