Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 755404..756064 Replicon chromosome
Accession NZ_CP015379
Organism Hafnia alvei strain HUMV-5920

Toxin (Protein)


Gene name cptA Uniprot ID A0A2J9GZT7
Locus tag A6V27_RS03430 Protein ID WP_063585844.1
Coordinates 755404..755817 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A097QZ09
Locus tag A6V27_RS03435 Protein ID WP_025801623.1
Coordinates 755798..756064 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6V27_RS03410 751228..752961 - 1734 WP_063585843.1 single-stranded-DNA-specific exonuclease RecJ -
A6V27_RS03415 752967..753683 - 717 WP_025801619.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
A6V27_RS03420 753711..754610 - 900 WP_040046379.1 site-specific tyrosine recombinase XerD -
A6V27_RS03425 754815..755333 + 519 WP_040046181.1 flavodoxin FldB -
A6V27_RS03430 755404..755817 - 414 WP_063585844.1 protein YgfX Toxin
A6V27_RS03435 755798..756064 - 267 WP_025801623.1 FAD assembly factor SdhE Antitoxin
A6V27_RS03440 756442..757431 + 990 WP_063585845.1 tRNA-modifying protein YgfZ -
A6V27_RS03445 757586..758404 - 819 WP_063585846.1 shikimate 5-dehydrogenase -
A6V27_RS03450 758606..759490 - 885 WP_063585847.1 nucleoside-specific channel-forming protein Tsx -
A6V27_RS03455 760151..760801 + 651 WP_025801627.1 hemolysin III family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-133)

Antitoxin

Flavinator of succinate dehydrogenase

(8-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16256.02 Da        Isoelectric Point: 8.5147

>T62947 WP_063585844.1 NZ_CP015379:c755817-755404 [Hafnia alvei]
VDQWRCDVRVSWRTQLLLLVTHGILILLILLAPWPENYSFYWLVLLTLVVFECIRSQKQIAKIQGEFSFLADNHIQWQQN
EWELCKTPWISDFGALLPLKNVKQQGKKKRLWIAADSLTPEAWCHLRRTLMQTHQSD

Download         Length: 414 bp

>T62947 NZ_CP015379:c755817-755404 [Hafnia alvei]
GTGGACCAATGGCGTTGTGATGTACGAGTGTCATGGCGAACGCAACTTTTGTTGTTGGTTACGCATGGCATTCTGATTTT
GTTGATTTTGCTAGCACCCTGGCCGGAAAACTATAGTTTTTATTGGTTGGTGTTGCTGACTTTAGTTGTGTTTGAATGTA
TCCGCAGCCAAAAGCAGATCGCTAAGATTCAGGGAGAGTTTAGCTTTCTAGCGGATAATCATATTCAATGGCAACAGAAC
GAATGGGAGTTATGTAAGACGCCTTGGATCAGTGATTTTGGCGCATTGCTACCCTTGAAAAATGTGAAGCAGCAGGGAAA
GAAAAAGCGTTTATGGATTGCGGCAGACAGTTTGACGCCAGAAGCATGGTGCCATTTGCGCCGCACTTTGATGCAAACGC
ACCAGAGTGATTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10345.85 Da        Isoelectric Point: 6.0684

>AT62947 WP_025801623.1 NZ_CP015379:c756064-755798 [Hafnia alvei]
MDIGNKSRIHWACRRGMRELDISIMPFFEHEYDSLSDADKQTFVRLLECDDPDLFNWLMNHGSPKDPELAHMVKLIQTRN
KDRGPMAL

Download         Length: 267 bp

>AT62947 NZ_CP015379:c756064-755798 [Hafnia alvei]
ATGGATATAGGAAATAAATCACGCATTCATTGGGCTTGCCGCCGCGGTATGCGTGAGTTGGATATCTCCATTATGCCGTT
TTTCGAACATGAGTATGATTCACTGAGCGATGCAGATAAACAGACATTTGTGCGCTTACTTGAGTGCGACGATCCCGATC
TCTTTAATTGGCTCATGAACCACGGTTCACCCAAGGATCCTGAATTAGCGCATATGGTTAAACTTATTCAAACGCGAAAC
AAAGATCGTGGACCAATGGCGTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J9GZT7

Antitoxin

Source ID Structure
AlphaFold DB A0A097QZ09

References