Detailed information of TA system TA062946

Bioinformatically predicted

Overview

TA module

• Type: VII
• Classification (family/domain): HepT-MntA/HepT(toxin)
• Location: 2296397..2297186
• Replicon: chromosome
• Accession: NZ_CP015378
• Organism: Fictibacillus phosphorivorans strain G25-29

Toxin (Protein)

• Gene name: hepT
• Uniprot ID: A0A160INH6
• Locus tag: ABE65_RS11700
• Protein ID: WP_066395032.1
• Coordinates: 2296397..2296804 (-)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: mntA
• Uniprot ID: -
• Locus tag: ABE65_RS11705
• Protein ID: WP_197480362.1
• Coordinates: 2296794..2297186 (-)
• Length: 131 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ABE65_RS11675	2291627..2292166	-	540	WP_066395027.1	DJ-1/PfpI family protein	-
ABE65_RS11680	2292255..2292584	-	330	WP_066395028.1	hypothetical protein	-
ABE65_RS21895	2292964..2293104	-	141	WP_156499167.1	hypothetical protein	-
ABE65_RS11685	2293133..2293747	-	615	WP_066400093.1	undecaprenyl-diphosphatase	-
ABE65_RS11690	2294034..2294696	-	663	WP_066395029.1	Type 1 glutamine amidotransferase-like domain-containing protein	-
ABE65_RS11695	2294889..2295917	-	1029	WP_066395030.1	LD-carboxypeptidase	-
ABE65_RS11700	2296397..2296804	-	408	WP_066395032.1	DUF86 domain-containing protein	Toxin
ABE65_RS11705	2296794..2297186	-	393	WP_197480362.1	nucleotidyltransferase domain-containing protein	Antitoxin
ABE65_RS11715	2297850..2298677	-	828	WP_066395041.1	polyamine aminopropyltransferase	-
ABE65_RS11720	2298694..2299011	-	318	WP_197480363.1	multidrug efflux SMR transporter	-
ABE65_RS11725	2299008..2299349	-	342	WP_066395045.1	multidrug efflux SMR transporter	-
ABE65_RS11730	2299364..2299936	-	573	WP_066395050.1	TetR/AcrR family transcriptional regulator	-
ABE65_RS11735	2300027..2301196	-	1170	WP_066395053.1	cation:proton antiporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2254661..2316547	61886

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease HepT-like (18-131)

Antitoxin

• Polymerase beta, nucleotidyltransferase (3-93)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 15649.13 Da
• Isoelectric Point: 5.2383

>T62946 WP_066395032.1 NZ_CP015378:c2296804-2296397 [Fictibacillus phosphorivorans]
MKNDVILNKISIIERCLKRINEEYDNNPLNLENFTKQDSIILNIQRACEAAIDLGMHVVAEKKLGIPQTSRETFDLLQQD
NIITMDLCKGLKAMVGFRNIAVHDYQEVNLEIVQKIIEKHLIDFKTYTEQILAYN

Nucleotide

• Length: 408 bp

>T62946 NZ_CP015378:c2296804-2296397 [Fictibacillus phosphorivorans]
ATGAAAAATGATGTGATACTAAACAAGATTAGCATCATCGAACGATGCTTAAAACGGATCAATGAAGAGTATGATAACAA
CCCACTAAATTTAGAGAACTTTACGAAACAAGATTCAATCATCTTGAATATTCAGCGTGCTTGTGAAGCGGCGATTGATC
TCGGTATGCATGTGGTAGCAGAGAAGAAGCTAGGAATTCCTCAAACCAGTCGAGAGACGTTTGATCTCCTACAACAAGAT
AACATCATTACAATGGACCTATGTAAGGGATTAAAGGCAATGGTAGGTTTTCGCAACATCGCTGTTCATGACTATCAAGA
AGTGAACCTTGAGATTGTACAGAAAATTATCGAGAAACACCTTATAGACTTTAAAACTTACACAGAACAAATTTTGGCAT
ATAACTAA

Antitoxin

Protein

• Length: 131 a.a.
• Molecular weight: 14994.19 Da
• Isoelectric Point: 4.4571

>AT62946 WP_197480362.1 NZ_CP015378:c2297186-2296794 [Fictibacillus phosphorivorans]
IEEQVISFLSEKLEPYLIVVFGSTAKGTDRVDSDLDIGYLSDQKIEKYDRFMLSQELASLIDKDVDLVDLNQASTVFAAQ
IIQSGKTILCKDDKRRMEFEMKTLKMYAKLNEEREIVIKRIEESGSIYEK

Nucleotide

• Length: 393 bp

>AT62946 NZ_CP015378:c2297186-2296794 [Fictibacillus phosphorivorans]
ATAGAGGAACAAGTTATATCTTTTCTAAGTGAAAAACTAGAACCTTATCTGATTGTTGTTTTCGGTTCCACGGCTAAAGG
AACGGACCGAGTAGACAGTGATCTAGATATCGGGTATTTGAGTGATCAAAAAATAGAGAAGTACGATCGATTTATGTTGT
CTCAAGAGCTTGCTTCATTGATTGATAAGGATGTTGATCTCGTTGATTTGAATCAAGCTTCTACCGTATTCGCGGCTCAA
ATTATTCAATCCGGTAAAACGATACTCTGTAAAGATGATAAACGCAGGATGGAATTTGAGATGAAGACACTTAAAATGTA
TGCGAAATTAAACGAAGAACGAGAGATCGTGATCAAAAGAATTGAAGAGAGTGGATCAATCTATGAAAAATGA

Structures

Toxin

• AlphaFold DB: A0A160INH6