Detailed information of TA system TA062939

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 2243733..2244238
• Replicon: chromosome
• Accession: NZ_CP015377
• Organism: Pseudomonas aeruginosa strain BAMCPA07-48

Toxin (Protein)

• Gene name: parE
• Uniprot ID: V6A7K8
• Locus tag: A6R75_RS10435
• Protein ID: WP_003083773.1
• Coordinates: 2243733..2244014 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1C7BDS9
• Locus tag: A6R75_RS10440
• Protein ID: WP_003083775.1
• Coordinates: 2244011..2244238 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A6R75_RS10410	2238984..2240333	+	1350	WP_003137006.1	C4-dicarboxylate transporter DctA	-
A6R75_RS10415	2240382..2241068	+	687	WP_003083762.1	FadR family transcriptional regulator	-
A6R75_RS10420	2241169..2241903	+	735	WP_003083764.1	GntR family transcriptional regulator	-
A6R75_RS10425	2242107..2242493	+	387	WP_003083767.1	aegerolysin family protein	-
A6R75_RS10430	2242525..2243433	-	909	WP_003083769.1	LysR family transcriptional regulator	-
A6R75_RS10435	2243733..2244014	-	282	WP_003083773.1	type II toxin-antitoxin system toxin ParE	Toxin
A6R75_RS10440	2244011..2244238	-	228	WP_003083775.1	CopG family ribbon-helix-helix protein	Antitoxin
A6R75_RS10445	2244414..2245034	-	621	WP_023092259.1	hypothetical protein	-
A6R75_RS10450	2245135..2245635	+	501	WP_003101228.1	LEA type 2 family protein	-
A6R75_RS10455	2245708..2246049	+	342	WP_003101229.1	alkylphosphonate utilization protein	-
A6R75_RS10460	2246130..2247557	-	1428	WP_023092260.1	GABA permease	-
A6R75_RS10465	2247726..2249219	-	1494	WP_003101230.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10462.19 Da
• Isoelectric Point: 10.0435

>T62939 WP_003083773.1 NZ_CP015377:c2244014-2243733 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Nucleotide

• Length: 282 bp

>T62939 NZ_CP015377:c2244014-2243733 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCCCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCTTTTCGGGTAAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8556.58 Da
• Isoelectric Point: 5.5740

>AT62939 WP_003083775.1 NZ_CP015377:c2244238-2244011 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT62939 NZ_CP015377:c2244238-2244011 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCGTATCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Structures

Toxin

• PDB: 6XRW

Antitoxin

• AlphaFold DB: A0A1C7BDS9