Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 22079..22616 Replicon plasmid unnamed 3
Accession NZ_CP015374
Organism Pandoraea pnomenusa strain MCB032

Toxin (Protein)


Gene name relE Uniprot ID A0A2L0X163
Locus tag A6P55_RS25970 Protein ID WP_060986098.1
Coordinates 22079..22360 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2L0X100
Locus tag A6P55_RS25975 Protein ID WP_060986097.1
Coordinates 22347..22616 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6P55_RS26760 17503..17694 + 192 WP_081043765.1 antitoxin VbhA family protein -
A6P55_RS25945 17711..18481 - 771 WP_081256097.1 hypothetical protein -
A6P55_RS25950 18612..19843 - 1232 Protein_19 DNA cytosine methyltransferase -
A6P55_RS25955 20149..20780 - 632 Protein_20 recombinase family protein -
A6P55_RS25960 20922..21305 - 384 WP_031943200.1 hypothetical protein -
A6P55_RS25965 21302..21864 - 563 Protein_22 recombinase family protein -
A6P55_RS25970 22079..22360 - 282 WP_060986098.1 type II toxin-antitoxin system YafQ family toxin Toxin
A6P55_RS25975 22347..22616 - 270 WP_060986097.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
A6P55_RS25980 22929..23396 + 468 WP_063599784.1 hypothetical protein -
A6P55_RS25985 23471..23755 + 285 WP_063599785.1 hypothetical protein -
A6P55_RS25990 23759..24067 + 309 WP_063599782.1 type II toxin-antitoxin system RelE/ParE family toxin -
A6P55_RS25995 24158..24532 + 375 WP_014125932.1 hypothetical protein -
A6P55_RS26000 24637..24891 + 255 WP_146039733.1 hypothetical protein -
A6P55_RS26005 24888..26096 + 1209 WP_081256098.1 replication initiator protein A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..29016 29016
- inside IScluster/Tn - - 21385..28198 6813


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(8-82)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10657.05 Da        Isoelectric Point: 9.0398

>T62913 WP_060986098.1 NZ_CP015374:c22360-22079 [Pandoraea pnomenusa]
MRTIDRSSAFKRDFKREAKGQHRATLDDALKPVLLALATDQPLDARHRDHDLSGDWAGYRECHIKPDLLLIYRKSDSDTL
RLARLGSHSELFG

Download         Length: 282 bp

>T62913 NZ_CP015374:c22360-22079 [Pandoraea pnomenusa]
ATGCGGACGATTGATCGTTCGTCCGCGTTCAAGCGCGATTTCAAGCGCGAGGCCAAGGGACAGCACCGTGCCACGCTCGA
TGACGCGCTCAAGCCGGTGCTGCTCGCGCTGGCGACCGATCAGCCGTTGGACGCGCGCCACCGCGACCATGATCTTTCCG
GCGATTGGGCGGGCTACCGCGAGTGCCACATCAAGCCCGACCTGCTGCTGATTTACCGCAAGTCCGATTCCGACACTCTG
CGACTGGCGCGGCTTGGCTCGCATAGCGAGCTTTTCGGCTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9688.09 Da        Isoelectric Point: 6.4667

>AT62913 WP_060986097.1 NZ_CP015374:c22616-22347 [Pandoraea pnomenusa]
MSTTADTYVRARIDTNTKERAASALEAMGLSISDAIRLLMLRIADEHRLPFDVKVPNATTKKAIAELEAGKGKKFASVDN
LMADLHADD

Download         Length: 270 bp

>AT62913 NZ_CP015374:c22616-22347 [Pandoraea pnomenusa]
ATGAGCACTACAGCCGACACCTACGTCCGCGCCCGCATCGACACCAACACCAAGGAACGCGCCGCCAGCGCACTCGAAGC
AATGGGCTTGTCGATTTCCGACGCCATCCGCCTGTTGATGCTGCGCATCGCCGATGAGCACCGCTTGCCTTTTGACGTGA
AGGTGCCCAACGCCACGACCAAAAAGGCGATTGCCGAACTGGAAGCGGGCAAGGGCAAGAAGTTCGCCAGCGTGGACAAC
CTAATGGCAGACCTGCATGCGGACGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2L0X163

Antitoxin

Source ID Structure
AlphaFold DB A0A2L0X100

References