Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 46098..46678 Replicon plasmid unnamed 2
Accession NZ_CP015373
Organism Pandoraea pnomenusa strain MCB032

Toxin (Protein)


Gene name pemK Uniprot ID U3G5Y5
Locus tag A6P55_RS25650 Protein ID WP_009238012.1
Coordinates 46098..46424 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID T2N032
Locus tag A6P55_RS25655 Protein ID WP_009238013.1
Coordinates 46421..46678 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6P55_RS25645 45548..46084 - 537 WP_037031213.1 hypothetical protein -
A6P55_RS25650 46098..46424 - 327 WP_009238012.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
A6P55_RS25655 46421..46678 - 258 WP_009238013.1 antitoxin Antitoxin
A6P55_RS25660 46860..47426 + 567 WP_063599763.1 recombinase family protein -
A6P55_RS25665 47714..48145 - 432 WP_001665065.1 OmpA family protein -
A6P55_RS25670 48161..48859 - 699 WP_011114053.1 conjugal transfer protein TraX -
A6P55_RS25675 48859..49125 - 267 WP_010890140.1 hypothetical protein -
A6P55_RS25680 49154..49789 - 636 WP_011114052.1 transglycosylase SLT domain-containing protein -
A6P55_RS25685 49803..50390 - 588 WP_010890138.1 conjugal transfer protein TrbM -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..85291 85291
- flank IS/Tn - - 46860..47426 566


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-107)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11618.53 Da        Isoelectric Point: 8.0459

>T62912 WP_009238012.1 NZ_CP015373:c46424-46098 [Pandoraea pnomenusa]
MKRGDIYLVSLDPTAGHEQSGSRPVLVVSPAEFNEATKLPVILPITNGGEFARRLGFAVPVTGIKTTGVVRCDQPRVIDL
AARHARKVDTLPAPLMDEVLAKVATLFE

Download         Length: 327 bp

>T62912 NZ_CP015373:c46424-46098 [Pandoraea pnomenusa]
ATGAAGCGGGGCGACATTTATCTCGTGTCGCTCGATCCGACTGCCGGACACGAGCAAAGCGGTAGCCGTCCCGTCCTGGT
CGTGTCGCCCGCCGAGTTCAACGAGGCCACCAAGTTGCCGGTGATCCTACCCATCACCAACGGCGGCGAGTTTGCCCGCC
GCCTTGGTTTCGCCGTACCTGTGACTGGTATCAAGACTACCGGCGTCGTGCGTTGTGACCAGCCGCGAGTAATCGACCTG
GCCGCACGTCACGCCCGCAAGGTAGACACACTACCAGCGCCGCTCATGGATGAAGTGCTGGCGAAAGTCGCCACTCTCTT
TGAGTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9070.37 Da        Isoelectric Point: 4.8884

>AT62912 WP_009238013.1 NZ_CP015373:c46678-46421 [Pandoraea pnomenusa]
MHTTNLRKVGGSIMLAVPPAFLDQLHLQAGATVGLAVDHGCLVVNPNPRPRYTLAELLAVSDYSQPQPADEREWVDAPAV
GGELL

Download         Length: 258 bp

>AT62912 NZ_CP015373:c46678-46421 [Pandoraea pnomenusa]
ATGCACACAACCAATCTGCGCAAGGTCGGCGGCTCGATCATGTTGGCCGTGCCGCCGGCCTTCCTCGATCAACTGCACCT
GCAAGCCGGCGCAACGGTCGGCCTCGCAGTCGATCATGGCTGCCTGGTGGTCAACCCCAATCCACGCCCGCGCTACACGC
TCGCGGAGTTGCTGGCCGTGTCGGACTATTCGCAGCCGCAACCAGCCGATGAACGCGAATGGGTTGATGCACCCGCCGTG
GGCGGTGAACTGCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A117DS90

Antitoxin

Source ID Structure
AlphaFold DB A0A100HP96

References