Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-RelB
Location 22114..22645 Replicon plasmid unnamed 2
Accession NZ_CP015373
Organism Pandoraea pnomenusa strain MCB032

Toxin (Protein)


Gene name relE Uniprot ID I2ALI9
Locus tag A6P55_RS25515 Protein ID WP_011114071.1
Coordinates 22114..22395 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID I2ALI8
Locus tag A6P55_RS25520 Protein ID WP_011114070.1
Coordinates 22382..22645 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6P55_RS25505 17472..20387 + 2916 WP_003049965.1 Tn3-like element IS1071 family transposase -
A6P55_RS25510 20570..20770 + 201 WP_003159550.1 Tn3 family transposase -
A6P55_RS25515 22114..22395 - 282 WP_011114071.1 type II toxin-antitoxin system YafQ family toxin Toxin
A6P55_RS25520 22382..22645 - 264 WP_011114070.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
A6P55_RS25525 22818..23246 + 429 WP_011114069.1 antirestriction protein -
A6P55_RS25530 23246..23509 + 264 WP_011296181.1 hypothetical protein -
A6P55_RS25535 23521..24729 + 1209 WP_011114068.1 hypothetical protein -
A6P55_RS25540 24746..25003 + 258 WP_011114067.1 hypothetical protein -
A6P55_RS25545 25161..25397 + 237 WP_011114066.1 stable inheritance protein KleA -
A6P55_RS25550 25606..25932 + 327 WP_011114065.1 hypothetical protein -
A6P55_RS25555 25934..26263 + 330 WP_011114064.1 DUF2761 domain-containing protein -
A6P55_RS25560 26370..26678 + 309 WP_011114062.1 KorA protein -
A6P55_RS25565 26675..27439 + 765 WP_011114061.1 ParA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..85291 85291


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-83)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10743.19 Da        Isoelectric Point: 7.4750

>T62911 WP_011114071.1 NZ_CP015373:c22395-22114 [Pandoraea pnomenusa]
MRQIERTGQFKRDYKREAKGQHRATLDADLVPVLVALADDQPLEPRHRDHALTGDWKDHRDCHVKPDLVLIYQKPDADTL
RLVRLGSHSELGL

Download         Length: 282 bp

>T62911 NZ_CP015373:c22395-22114 [Pandoraea pnomenusa]
ATGCGGCAGATTGAGCGCACCGGCCAGTTCAAGCGCGACTACAAGCGCGAGGCGAAAGGGCAGCACCGGGCCACGCTCGA
CGCCGACCTGGTGCCCGTCCTGGTCGCGCTCGCCGACGACCAGCCGCTGGAACCTCGGCACCGCGACCACGCGCTGACCG
GGGACTGGAAGGATCACCGGGATTGCCACGTCAAGCCCGACCTGGTGCTGATCTACCAGAAGCCCGACGCCGACACGCTG
CGCCTGGTGCGCCTCGGCTCTCACTCCGAACTCGGCTTGTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9255.82 Da        Isoelectric Point: 5.7905

>AT62911 WP_011114070.1 NZ_CP015373:c22645-22382 [Pandoraea pnomenusa]
MAANQLVQTRIDGAIKEEAAAVLAAMGLTVSDAVRLLLTKVAQDKALPFEPLIPNATTIEAMKEARKGKLPRFATVNDLM
ADLHAAD

Download         Length: 264 bp

>AT62911 NZ_CP015373:c22645-22382 [Pandoraea pnomenusa]
ATGGCTGCAAACCAGCTCGTACAAACGCGCATCGACGGCGCGATCAAGGAAGAAGCGGCGGCCGTCCTGGCCGCGATGGG
CCTTACCGTGTCCGACGCGGTGCGGCTGCTGCTCACGAAGGTGGCCCAGGACAAGGCGCTGCCCTTCGAGCCGCTGATTC
CGAACGCCACCACCATCGAGGCGATGAAGGAAGCCCGCAAGGGCAAGCTGCCGCGCTTCGCCACCGTCAACGATCTGATG
GCCGATCTGCATGCGGCAGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1U9V4I5

Antitoxin

Source ID Structure
AlphaFold DB A0A1U9V3I2

References