Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 3838175..3840041 Replicon chromosome
Accession NZ_CP015371
Organism Pandoraea pnomenusa strain MCB032

Toxin (Protein)


Gene name doc Uniprot ID A0A378YWT3
Locus tag A6P55_RS17170 Protein ID WP_038620228.1
Coordinates 3838175..3839101 (+) Length 309 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag A6P55_RS17175 Protein ID WP_162835271.1
Coordinates 3839103..3840041 (+) Length 313 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6P55_RS17145 3833507..3834583 + 1077 WP_031627377.1 porin -
A6P55_RS17150 3834993..3835778 + 786 WP_029754279.1 ABC transporter ATP-binding protein -
A6P55_RS17155 3835819..3836601 + 783 WP_023597214.1 ABC transporter permease -
A6P55_RS17160 3836618..3837409 + 792 WP_023597213.1 SDR family oxidoreductase -
A6P55_RS17165 3837468..3838025 + 558 WP_023597212.1 cupin domain-containing protein -
A6P55_RS17170 3838175..3839101 + 927 WP_038620228.1 alpha/beta fold hydrolase Toxin
A6P55_RS17175 3839103..3840041 + 939 WP_162835271.1 IclR family transcriptional regulator Antitoxin
A6P55_RS17180 3840038..3840844 + 807 WP_023597209.1 SDR family oxidoreductase -
A6P55_RS17185 3840837..3842489 + 1653 WP_063599029.1 thiamine pyrophosphate-binding protein -
A6P55_RS17190 3842482..3843300 + 819 WP_038620230.1 aspartate dehydrogenase -
A6P55_RS17195 3843314..3844810 + 1497 WP_063599030.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(59-291)

Antitoxin

Transcription regulator IclR, C-terminal

(167-290)


Sequences

Toxin        


Download         Length: 309 a.a.        Molecular weight: 31575.68 Da        Isoelectric Point: 6.2299

>T62910 WP_038620228.1 NZ_CP015371:3838175-3839101 [Pandoraea pnomenusa]
MQAQANSSEVSEVSADADVPDVAALRARLAAFPYRTVTTRAGTVGYRCATAQAADAVPVVMLHGIGSGAASWLAQFEATG
LGASLYAWDAPGYGQTTNVAPAEPDADAYADALEAWLDALGLARVAVAGHSLGAIMASRFAARAPHRVLGLFLCSPAGGY
GKADPAVRAAKRDSRLAMLHKLGPAGMARERSDNLVAPNAADLPRAWVKWNMSRVRPEGYAQATHLLSNGDVAGDLARYT
AAKAGPVAVAVGAQDAVTPPASCQTIADVAGVPLQIIEGAGHASYIETPDVLDAALAAWLGRIAAGER

Download         Length: 927 bp

>T62910 NZ_CP015371:3838175-3839101 [Pandoraea pnomenusa]
ATGCAAGCCCAAGCCAACTCGTCCGAAGTGTCCGAAGTGTCCGCAGACGCCGATGTCCCCGATGTCGCCGCCCTGCGCGC
GCGCCTGGCGGCCTTCCCGTATCGCACCGTCACCACGCGCGCGGGGACCGTCGGCTATCGCTGCGCGACGGCGCAAGCCG
CTGATGCCGTCCCTGTGGTGATGCTGCACGGCATCGGGTCGGGGGCGGCGTCGTGGCTGGCGCAGTTCGAAGCGACGGGC
CTTGGCGCCTCGCTTTATGCCTGGGATGCCCCTGGCTACGGTCAGACAACGAATGTCGCGCCTGCCGAGCCGGATGCCGA
CGCCTACGCCGACGCCCTCGAAGCGTGGCTCGATGCGCTCGGTCTTGCGCGCGTGGCGGTGGCCGGCCATTCGCTCGGCG
CGATCATGGCGTCGAGGTTTGCGGCGCGTGCGCCGCACCGCGTGCTCGGCCTGTTTCTGTGCTCGCCGGCAGGGGGCTAC
GGCAAGGCCGACCCGGCAGTACGGGCGGCCAAGCGCGACAGCCGCCTGGCGATGCTTCACAAACTCGGTCCCGCGGGCAT
GGCGCGCGAACGCAGCGACAACCTCGTGGCACCGAACGCGGCCGACCTGCCGCGCGCCTGGGTGAAGTGGAACATGTCGC
GGGTGCGGCCCGAGGGCTACGCGCAGGCGACCCATCTGCTCTCGAACGGCGATGTGGCGGGCGACCTGGCCCGGTACACG
GCGGCCAAGGCCGGCCCCGTCGCGGTGGCCGTCGGCGCCCAGGATGCCGTCACCCCTCCCGCGAGCTGCCAGACGATTGC
CGACGTCGCCGGTGTGCCGCTTCAGATTATCGAAGGGGCCGGCCACGCGTCTTACATTGAAACGCCCGACGTGCTCGATG
CCGCGCTTGCCGCGTGGCTTGGGCGCATTGCGGCAGGGGAGCGTTGA

Antitoxin


Download         Length: 313 a.a.        Molecular weight: 33953.70 Da        Isoelectric Point: 6.0582

>AT62910 WP_162835271.1 NZ_CP015371:3839103-3840041 [Pandoraea pnomenusa]
MAPANPKRAVAAASIDDSTQDVQDMQDTLDDEVAEAAPAESRYLVPGLERGLRILTQFSPRESVFSAPELSQRLGIPRTT
VFRLLQTLEAMGFLERAGSEKNFRLGVAVLRLGFEYLSSLELTDLGIPIIERLRDATQLTSHIVIRDGRDIVFVAKAQSV
AGVFNSIKVNVGTRLPAHATVHGHVLMGDLTLAELRALYPEKTLEKYTPQTPETLAELFERVREDAERGYAVSASSFERG
ISVVSAPVRNDAGRICAAITVTIPRANIDSAMLDAGLIGQVREAADALSHRLNYRPGGDGRTSPYMKSLGLK

Download         Length: 939 bp

>AT62910 NZ_CP015371:3839103-3840041 [Pandoraea pnomenusa]
ATGGCACCCGCCAATCCGAAGCGCGCCGTCGCCGCGGCGTCGATCGACGACAGCACGCAGGACGTACAGGACATGCAGGA
CACGCTGGACGACGAAGTCGCCGAGGCGGCGCCCGCCGAATCGCGTTACCTCGTGCCGGGGCTGGAGCGCGGCCTGCGCA
TCCTGACGCAATTCTCGCCGCGCGAGTCGGTCTTCAGCGCACCGGAGCTCTCGCAGCGCCTCGGTATTCCGCGCACGACG
GTCTTCCGTTTGCTGCAAACGCTTGAGGCGATGGGCTTTCTCGAGCGCGCGGGCAGCGAAAAGAACTTCCGTCTGGGCGT
GGCGGTGCTGCGTCTGGGCTTCGAATACCTGAGCTCGCTGGAGCTCACCGATCTGGGCATTCCCATCATCGAGCGGCTGC
GCGATGCCACCCAGCTGACGTCGCACATCGTGATTCGCGACGGGCGCGACATCGTGTTCGTGGCCAAGGCGCAGAGCGTG
GCCGGGGTGTTCAATTCGATCAAGGTCAACGTCGGTACGCGCTTGCCTGCGCATGCCACGGTCCACGGCCATGTGCTGAT
GGGCGATCTCACGCTCGCCGAACTGCGTGCGCTGTATCCCGAGAAGACGCTGGAGAAATACACGCCGCAGACCCCCGAGA
CGCTCGCCGAGTTGTTCGAGCGCGTGCGCGAGGACGCCGAACGCGGGTATGCCGTCTCGGCCTCGTCCTTCGAGCGCGGC
ATAAGCGTCGTGAGCGCGCCGGTACGCAACGACGCGGGCCGCATCTGCGCCGCGATCACGGTCACGATCCCGCGCGCGAA
CATCGATTCGGCAATGCTCGACGCGGGACTGATCGGGCAGGTGCGCGAAGCCGCCGACGCGCTCTCGCACCGTCTGAATT
ACCGGCCGGGCGGCGACGGCCGCACCTCCCCCTACATGAAGTCACTGGGATTGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378YWT3

Antitoxin

Source ID Structure

References