Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-AbrB
Location 980368..980956 Replicon chromosome
Accession NZ_CP015363
Organism Ferroplasma acidiphilum strain Y

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag fad_RS04885 Protein ID WP_196795575.1
Coordinates 980368..980733 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag fad_RS04890 Protein ID WP_081142301.1
Coordinates 980714..980956 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
fad_RS04865 (FAD_0988) 975495..976529 - 1035 WP_081142291.1 C4-dicarboxylate ABC transporter -
fad_RS04870 (FAD_0989) 976619..977158 + 540 WP_081142293.1 helix-turn-helix domain-containing protein -
fad_RS04875 (FAD_0990) 977241..977891 - 651 WP_081142295.1 type II toxin-antitoxin system death-on-curing family toxin -
fad_RS04880 (FAD_0991) 978293..980203 + 1911 WP_081142297.1 DUF2075 domain-containing protein -
fad_RS04885 (FAD_0992) 980368..980733 - 366 WP_196795575.1 PIN domain-containing protein Toxin
fad_RS04890 (FAD_0993) 980714..980956 - 243 WP_081142301.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
fad_RS04895 (FAD_0994) 981241..982431 - 1191 WP_081142303.1 MFS transporter -
fad_RS04900 (FAD_0995) 982623..983114 - 492 WP_081142305.1 peroxiredoxin -
fad_RS04905 (FAD_0996) 983484..984710 + 1227 WP_155951129.1 MFS transporter -
fad_RS04910 (FAD_0997) 984741..985442 - 702 WP_081142309.1 DUF996 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-118)

Antitoxin

SpoVT-AbrB domain

(4-46)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 14261.76 Da        Isoelectric Point: 6.4782

>T62905 WP_196795575.1 NZ_CP015363:c980733-980368 [Ferroplasma acidiphilum]
MEEAVFDTNVIIAIIIENDINHKKALELWKKIDKAYVPMISVIEFNYFLIKHSLPVAITKELINDEKVNIIPTQKDDVFF
SIKSNIKSYDDFNDMIILNISKRIKKQLITFDVELKKLYDR

Download         Length: 366 bp

>T62905 NZ_CP015363:c980733-980368 [Ferroplasma acidiphilum]
TTGGAAGAAGCAGTCTTTGATACAAATGTTATTATTGCAATAATAATAGAGAATGATATTAACCATAAAAAAGCTCTAGA
ATTGTGGAAAAAAATCGATAAGGCATATGTACCTATGATATCTGTTATTGAATTCAATTATTTCCTCATTAAGCATTCTT
TACCTGTTGCTATAACAAAGGAGTTGATAAATGATGAAAAGGTCAATATTATACCAACACAAAAGGATGATGTATTTTTT
TCAATAAAAAGTAATATAAAAAGCTATGATGATTTTAATGATATGATAATATTAAACATTAGTAAAAGGATTAAGAAACA
GCTCATAACATTTGATGTTGAACTGAAAAAATTATATGACCGATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9189.68 Da        Isoelectric Point: 6.3684

>AT62905 WP_081142301.1 NZ_CP015363:c980956-980714 [Ferroplasma acidiphilum]
MEEVKITRNYQTTIPADIRDKLGIKIGDRILVYIDKDRIIMEKPKGDITKISIKLDKNIDAEYVEKVIREAGDEIGRSSL

Download         Length: 243 bp

>AT62905 NZ_CP015363:c980956-980714 [Ferroplasma acidiphilum]
ATGGAAGAAGTAAAAATCACAAGAAATTACCAGACTACAATACCTGCTGATATTAGAGATAAATTGGGAATAAAAATCGG
TGATAGAATCCTTGTTTATATAGATAAAGATAGAATTATAATGGAAAAACCGAAAGGTGACATTACAAAGATATCCATTA
AATTAGATAAAAATATAGATGCTGAATACGTAGAAAAGGTAATAAGGGAAGCAGGTGATGAAATTGGAAGAAGCAGTCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References