Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 4248368..4249011 Replicon chromosome
Accession NZ_CP015347
Organism Proteus mirabilis strain AOUC-001

Toxin (Protein)


Gene name vagD Uniprot ID D8L2J9
Locus tag AOUC001_RS19995 Protein ID WP_001044770.1
Coordinates 4248595..4249011 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D5KTK7
Locus tag AOUC001_RS19990 Protein ID WP_001261282.1
Coordinates 4248368..4248598 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOUC001_RS19965 4243940..4244806 - 867 WP_004118283.1 replication initiation protein -
AOUC001_RS21505 4245341..4245445 + 105 WP_032409716.1 hypothetical protein -
AOUC001_RS19970 4245574..4245831 + 258 WP_000764642.1 hypothetical protein -
AOUC001_RS19975 4245889..4246665 - 777 WP_000015958.1 site-specific integrase -
AOUC001_RS19980 4246662..4247405 - 744 WP_000129823.1 hypothetical protein -
AOUC001_RS19985 4247456..4247806 - 351 WP_000493378.1 hypothetical protein -
AOUC001_RS21510 4247950..4248411 - 462 WP_072202616.1 hypothetical protein -
AOUC001_RS19990 4248368..4248598 + 231 WP_001261282.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
AOUC001_RS19995 4248595..4249011 + 417 WP_001044770.1 type II toxin-antitoxin system VapC family toxin Toxin
AOUC001_RS20000 4249085..4249795 + 711 WP_004152334.1 ATP-binding protein -
AOUC001_RS20010 4249829..4250526 + 698 Protein_3933 IS1 family transposase -
AOUC001_RS20860 4250542..4250652 + 111 Protein_3934 mercuric transport protein periplasmic component -
AOUC001_RS20865 4250688..4251110 + 423 WP_001340589.1 organomercurial transporter MerC -
AOUC001_RS20020 4251162..4252856 + 1695 WP_000105636.1 mercury(II) reductase -
AOUC001_RS20025 4252874..4253236 + 363 WP_001277456.1 mercury resistance co-regulator MerD -
AOUC001_RS20030 4253233..4253469 + 237 WP_000993386.1 broad-spectrum mercury transporter MerE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catA1 / ant(3'')-Ia / dfrA1 / aph(3')-Ia / aac(3)-Ia / qacE / sul1 / blaKPC-2 - 4206605..4272181 65576
- flank IS/Tn - - 4249829..4250104 275


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15106.52 Da        Isoelectric Point: 7.1084

>T62901 WP_001044770.1 NZ_CP015347:4248595-4249011 [Proteus mirabilis]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGQRIVVSAITYSEMRFGATGPKASPRHVELVDAFCARLDAILPWDRA
AVDATTEIKVALRMAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVR

Download         Length: 417 bp

>T62901 NZ_CP015347:4248595-4249011 [Proteus mirabilis]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8756.83 Da        Isoelectric Point: 4.4692

>AT62901 WP_001261282.1 NZ_CP015347:4248368-4248598 [Proteus mirabilis]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQFEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp

>AT62901 NZ_CP015347:4248368-4248598 [Proteus mirabilis]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GYM2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GZG3

References