Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 4023922..4024523 Replicon chromosome
Accession NZ_CP015347
Organism Proteus mirabilis strain AOUC-001

Toxin (Protein)


Gene name doc Uniprot ID A0A2X2BIG8
Locus tag AOUC001_RS18910 Protein ID WP_004246497.1
Coordinates 4024140..4024523 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A1Z1SPN9
Locus tag AOUC001_RS18905 Protein ID WP_004246496.1
Coordinates 4023922..4024143 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOUC001_RS18880 4019743..4020201 + 459 WP_004246490.1 dUTP diphosphatase -
AOUC001_RS18885 4020321..4020926 + 606 WP_004246491.1 nucleoid occlusion factor SlmA -
AOUC001_RS18890 4021245..4021889 - 645 WP_017628713.1 orotate phosphoribosyltransferase -
AOUC001_RS18895 4021971..4022687 - 717 WP_004249760.1 ribonuclease PH -
AOUC001_RS18900 4022814..4023677 + 864 WP_004249947.1 YicC family protein -
AOUC001_RS18905 4023922..4024143 + 222 WP_004246496.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AOUC001_RS18910 4024140..4024523 + 384 WP_004246497.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
AOUC001_RS18915 4024931..4025245 + 315 WP_004246498.1 helix-turn-helix domain-containing protein -
AOUC001_RS18920 4025258..4026496 + 1239 WP_017628714.1 HipA domain-containing protein -
AOUC001_RS18925 4026853..4027752 - 900 WP_017628715.1 N-acetylmuramic acid 6-phosphate etherase -
AOUC001_RS18930 4027860..4028597 + 738 WP_004249950.1 sel1 repeat family protein -
AOUC001_RS18935 4028693..4029151 - 459 WP_017628716.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(5-115)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14471.53 Da        Isoelectric Point: 8.5125

>T62899 WP_004246497.1 NZ_CP015347:4024140-4024523 [Proteus mirabilis]
MIWVSAQEVIAFHDRILQRFPGVAGMSDPGRAEALIYRVQNRKHYEGITDVFELAATYWVAIARGHIFNDGNKRTAFFVT
MTFLYRNGIRIRDTGNMLENLTVEAATGEKTVDQLAKHLQNLVEKTN

Download         Length: 384 bp

>T62899 NZ_CP015347:4024140-4024523 [Proteus mirabilis]
ATGATATGGGTTAGCGCACAGGAAGTTATCGCTTTCCATGATCGTATATTACAACGTTTCCCAGGTGTGGCCGGTATGTC
CGATCCTGGCAGAGCGGAAGCTCTTATTTACCGGGTGCAAAACCGTAAACATTATGAAGGCATTACAGATGTGTTTGAAC
TGGCAGCAACTTATTGGGTCGCTATCGCTCGAGGGCACATATTTAATGACGGTAATAAACGTACCGCATTTTTTGTGACC
ATGACATTTCTCTATCGTAATGGCATCAGGATCCGCGATACTGGCAATATGCTGGAAAACTTAACAGTAGAAGCAGCTAC
AGGTGAGAAAACCGTCGACCAGTTAGCAAAACATCTACAAAACTTGGTAGAGAAAACTAACTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8260.23 Da        Isoelectric Point: 5.5667

>AT62899 WP_004246496.1 NZ_CP015347:4023922-4024143 [Proteus mirabilis]
MRTYTSTQARANISEVLDIATHGEPVEITRRDGCSAVVISKTEFESYQNAKLDAEFDMMMQRHGHTVEALTNR

Download         Length: 222 bp

>AT62899 NZ_CP015347:4023922-4024143 [Proteus mirabilis]
ATGCGTACATATACCTCGACACAAGCCCGAGCCAATATCTCAGAAGTATTAGATATTGCGACCCACGGTGAACCTGTTGA
AATCACCCGCAGAGACGGTTGTTCAGCGGTTGTTATCAGTAAAACTGAATTTGAGTCATACCAGAATGCTAAGCTAGATG
CAGAGTTTGATATGATGATGCAACGTCATGGACATACCGTAGAGGCACTGACAAATCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2X2BIG8

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z1SPN9

References