Detailed information of TA system TA062898

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2406630..2407275
• Replicon: chromosome
• Accession: NZ_CP015347
• Organism: Proteus mirabilis strain AOUC-001

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: B4ET86
• Locus tag: AOUC001_RS11295
• Protein ID: WP_004247035.1
• Coordinates: 2406630..2406815 (+)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: B4ET85
• Locus tag: AOUC001_RS11300
• Protein ID: WP_004247034.1
• Coordinates: 2406862..2407275 (+)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AOUC001_RS11265	2401870..2402097	+	228	WP_004247042.1	YejL family protein	-
AOUC001_RS11270	2402121..2403854	+	1734	WP_017628394.1	LPS biosynthesis-modulating metalloenzyme YejM	-
AOUC001_RS11280	2404261..2404575	+	315	WP_017628395.1	hypothetical protein	-
AOUC001_RS11285	2404639..2405190	+	552	WP_017628396.1	PH domain-containing protein	-
AOUC001_RS11290	2405749..2406519	-	771	Protein_2221	DUF1073 domain-containing protein	-
AOUC001_RS11295	2406630..2406815	+	186	WP_004247035.1	type II toxin-antitoxin system HicA family toxin	Toxin
AOUC001_RS11300	2406862..2407275	+	414	WP_004247034.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
AOUC001_RS11305	2407371..2407871	+	501	WP_004247032.1	response regulator	-
AOUC001_RS11310	2408185..2408478	+	294	Protein_2225	LysE family transporter	-
AOUC001_RS11315	2408591..2409169	-	579	WP_017628400.1	alpha/beta hydrolase	-
AOUC001_RS11325	2410019..2410765	+	747	WP_017628402.1	methyltransferase domain-containing protein	-
AOUC001_RS21580	2410936..2411112	-	177	WP_004247793.1	hypothetical protein	-
AOUC001_RS21585	2411564..2411722	+	159	WP_004247025.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 7049.30 Da
• Isoelectric Point: 10.9659

>T62898 WP_004247035.1 NZ_CP015347:2406630-2406815 [Proteus mirabilis]
MKSSELIKLLEKNGWILDRIKGSHHQFTHPDFSFVVTVPHPRKDLKKGTLNQIIKSAKLKN

Nucleotide

• Length: 186 bp

>T62898 NZ_CP015347:2406630-2406815 [Proteus mirabilis]
TTGAAAAGTTCGGAACTGATTAAGTTGTTAGAAAAAAACGGATGGATACTTGATAGAATAAAAGGAAGTCATCATCAATT
TACTCACCCTGATTTTTCTTTTGTTGTAACAGTACCGCATCCAAGAAAAGATTTAAAAAAAGGAACATTAAATCAAATTA
TTAAAAGTGCCAAACTGAAAAATTAA

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 15251.98 Da
• Isoelectric Point: 4.3830

>AT62898 WP_004247034.1 NZ_CP015347:2406862-2407275 [Proteus mirabilis]
MLYPAFIEIDEDGSASGWFPDIDGCIFAGDSIEEAHADARSAIDAHFELLSEKGLDIPSPKSQQEHLINSSGDYNNGIWL
LVDVDMDKYDGRAERINITLPHRLLSRIDTIVKTNPEYGSRSGFIATATRKELQKNI

Nucleotide

• Length: 414 bp

>AT62898 NZ_CP015347:2406862-2407275 [Proteus mirabilis]
ATGTTATATCCAGCCTTTATTGAAATTGATGAAGATGGTAGCGCAAGTGGCTGGTTCCCTGATATTGATGGTTGCATCTT
TGCGGGGGACAGTATTGAAGAAGCTCACGCAGATGCGAGGAGCGCTATTGATGCCCATTTTGAATTGTTAAGCGAGAAGG
GTTTAGATATCCCCTCTCCAAAATCTCAACAAGAGCATTTAATTAATTCTAGTGGTGATTACAATAATGGAATATGGCTT
TTAGTTGATGTTGATATGGATAAATACGACGGACGAGCAGAGCGTATTAATATCACATTGCCACATCGATTATTGAGTCG
CATCGATACTATCGTAAAAACAAATCCTGAATATGGGAGTCGTAGCGGATTTATTGCCACAGCAACCCGTAAAGAACTCC
AAAAGAATATTTAA

Structures

Toxin

• AlphaFold DB: B4ET86

Antitoxin

• AlphaFold DB: B4ET85