Detailed information of TA system TA062895

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-MqsA
• Location: 242579..243278
• Replicon: chromosome
• Accession: NZ_CP015347
• Organism: Proteus mirabilis strain AOUC-001

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: AOUC001_RS01195
• Protein ID: WP_017628658.1
• Coordinates: 242892..243278 (-)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B4EZ97
• Locus tag: AOUC001_RS01190
• Protein ID: WP_004246828.1
• Coordinates: 242579..242899 (-)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AOUC001_RS01160	237710..237985	-	276	WP_004246820.1	DNA-directed RNA polymerase subunit omega	-
AOUC001_RS01165	238040..238663	-	624	WP_004246821.1	guanylate kinase	-
AOUC001_RS01170	238964..239581	-	618	WP_004246822.1	trimeric intracellular cation channel family protein	-
AOUC001_RS01175	239718..241004	+	1287	WP_017628657.1	DUF3748 domain-containing protein	-
AOUC001_RS01180	241219..242103	+	885	WP_012368526.1	endonuclease/exonuclease/phosphatase family protein	-
AOUC001_RS01185	242096..242530	+	435	WP_004246827.1	hypothetical protein	-
AOUC001_RS01190	242579..242899	-	321	WP_004246828.1	helix-turn-helix domain-containing protein	Antitoxin
AOUC001_RS01195	242892..243278	-	387	WP_017628658.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AOUC001_RS01200	243440..245512	-	2073	WP_017628659.1	glycine--tRNA ligase subunit beta	-
AOUC001_RS01205	245522..246427	-	906	WP_004246832.1	glycine--tRNA ligase subunit alpha	-
AOUC001_RS01210	246678..247259	+	582	WP_012368524.1	DNA-3-methyladenine glycosylase I	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-125)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-95)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14322.65 Da
• Isoelectric Point: 10.0826

>T62895 WP_017628658.1 NZ_CP015347:c243278-242892 [Proteus mirabilis]
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFADGWKKS
SLSSKKTKEITDDELESYKDLAKDLFNANQNKIDKMIALGLLTEVRYD

Nucleotide

• Length: 387 bp

>T62895 NZ_CP015347:c243278-242892 [Proteus mirabilis]
ATGGTTATTTATAAAACAAAGATGTTCAAAAATAGTTTCAAAAAAATAACGCTTACGAATGCAGAACTAATCGCTATCGC
TACCGAAGTCCTTGCAGGACAATTTGAGGCAGATCTAGGTGGTGGTGTTATCAAGAAACGTGCCTGTATCCAAGGAAAAG
GTAAAAGTAGCGGAATTAGAACAATTATATTTTATAAGCAAGGGAATAATTTATTCTTTGCTGATGGTTGGAAAAAATCG
AGTTTAAGCTCTAAAAAAACCAAAGAGATCACAGATGATGAACTTGAGTCCTATAAAGATCTAGCAAAAGATCTCTTCAA
TGCAAATCAAAATAAAATAGATAAAATGATTGCACTAGGCCTTTTAACAGAGGTTAGATATGACTGA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12126.21 Da
• Isoelectric Point: 10.4411

>AT62895 WP_004246828.1 NZ_CP015347:c242899-242579 [Proteus mirabilis]
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI

Nucleotide

• Length: 321 bp

>AT62895 NZ_CP015347:c242899-242579 [Proteus mirabilis]
ATGACTGATAAAATGAAAGAAATGCTAAAATTTGCACAAGAAATGGAAGATGCAGGAGTCACTGATGGCAGTACAACTAA
ACGTATTGCCGCCAGAATAAAAGCGAAAGAATTACAGGCTAAGTATAAACATCCTACCCCTATGACAGGTGAAGATATAA
AAAGGATCCGTGAGCAAAATAATATCTCTCAATCTTCCCTTGCTTTGATATTGAATATGACTAAAGAAAGCGTTTCTAAG
TGGGAAAGAAACGAAATTAAGCCCAATGGTGCAGCACTACGACTTCTGCATTTAATAGATAAAAAAATATTATTCATCTA
G

Structures

Antitoxin

• AlphaFold DB: B4EZ97