Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 79095..79896 Replicon chromosome
Accession NZ_CP015347
Organism Proteus mirabilis strain AOUC-001

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0E0XS49
Locus tag AOUC001_RS00450 Protein ID WP_001094437.1
Coordinates 79519..79896 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0E0XTQ1
Locus tag AOUC001_RS00445 Protein ID WP_001390338.1
Coordinates 79095..79472 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOUC001_RS00415 76213..76371 + 159 WP_001323397.1 DUF905 family protein -
AOUC001_RS00420 76526..77344 + 819 WP_001234716.1 DUF945 domain-containing protein -
AOUC001_RS00430 77683..78156 + 474 WP_001387789.1 antirestriction protein -
AOUC001_RS00435 78172..78648 + 477 WP_001186773.1 RadC family protein -
AOUC001_RS00440 78711..78932 + 222 WP_000692300.1 DUF987 domain-containing protein -
AOUC001_RS00445 79095..79472 + 378 WP_001390338.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
AOUC001_RS00450 79519..79896 + 378 WP_001094437.1 TA system toxin CbtA family protein Toxin
AOUC001_RS00455 79893..80381 + 489 WP_000761716.1 hypothetical protein -
AOUC001_RS00460 80401..80598 + 198 WP_000772032.1 DUF957 domain-containing protein -
AOUC001_RS00465 80683..81528 + 846 WP_001274561.1 DUF4942 domain-containing protein -
AOUC001_RS00470 82072..83106 + 1035 WP_017628609.1 virulence RhuM family protein -
AOUC001_RS20305 83231..83383 - 153 Protein_94 transposase -
AOUC001_RS00475 84154..84474 + 321 WP_004246668.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13986.90 Da        Isoelectric Point: 7.3223

>T62894 WP_001094437.1 NZ_CP015347:79519-79896 [Proteus mirabilis]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

>T62894 NZ_CP015347:79519-79896 [Proteus mirabilis]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCATCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13745.44 Da        Isoelectric Point: 5.0463

>AT62894 WP_001390338.1 NZ_CP015347:79095-79472 [Proteus mirabilis]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTITLYAKGLTCEADTLGSCGYAYLAVYPTPAEPAITV

Download         Length: 378 bp

>AT62894 NZ_CP015347:79095-79472 [Proteus mirabilis]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCATCACACTGTATGCGAAGGGGCTGACCTGCGAAGCCGATACCCTTGGCAGTTG
TGGTTACGCTTATCTGGCTGTTTATCCGACACCGGCAGAGCCCGCAATCACCGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XS49

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XTQ1

References