Detailed information of TA system TA062894

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 79095..79896
• Replicon: chromosome
• Accession: NZ_CP015347
• Organism: Proteus mirabilis strain AOUC-001

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: A0A0E0XS49
• Locus tag: AOUC001_RS00450
• Protein ID: WP_001094437.1
• Coordinates: 79519..79896 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: A0A0E0XTQ1
• Locus tag: AOUC001_RS00445
• Protein ID: WP_001390338.1
• Coordinates: 79095..79472 (+)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AOUC001_RS00415	76213..76371	+	159	WP_001323397.1	DUF905 family protein	-
AOUC001_RS00420	76526..77344	+	819	WP_001234716.1	DUF945 domain-containing protein	-
AOUC001_RS00430	77683..78156	+	474	WP_001387789.1	antirestriction protein	-
AOUC001_RS00435	78172..78648	+	477	WP_001186773.1	RadC family protein	-
AOUC001_RS00440	78711..78932	+	222	WP_000692300.1	DUF987 domain-containing protein	-
AOUC001_RS00445	79095..79472	+	378	WP_001390338.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
AOUC001_RS00450	79519..79896	+	378	WP_001094437.1	TA system toxin CbtA family protein	Toxin
AOUC001_RS00455	79893..80381	+	489	WP_000761716.1	hypothetical protein	-
AOUC001_RS00460	80401..80598	+	198	WP_000772032.1	DUF957 domain-containing protein	-
AOUC001_RS00465	80683..81528	+	846	WP_001274561.1	DUF4942 domain-containing protein	-
AOUC001_RS00470	82072..83106	+	1035	WP_017628609.1	virulence RhuM family protein	-
AOUC001_RS20305	83231..83383	-	153	Protein_94	transposase	-
AOUC001_RS00475	84154..84474	+	321	WP_004246668.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13986.90 Da
• Isoelectric Point: 7.3223

>T62894 WP_001094437.1 NZ_CP015347:79519-79896 [Proteus mirabilis]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Nucleotide

• Length: 378 bp

>T62894 NZ_CP015347:79519-79896 [Proteus mirabilis]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCATCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 13745.44 Da
• Isoelectric Point: 5.0463

>AT62894 WP_001390338.1 NZ_CP015347:79095-79472 [Proteus mirabilis]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTITLYAKGLTCEADTLGSCGYAYLAVYPTPAEPAITV

Nucleotide

• Length: 378 bp

>AT62894 NZ_CP015347:79095-79472 [Proteus mirabilis]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCATCACACTGTATGCGAAGGGGCTGACCTGCGAAGCCGATACCCTTGGCAGTTG
TGGTTACGCTTATCTGGCTGTTTATCCGACACCGGCAGAGCCCGCAATCACCGTATAA

Structures

Toxin

• AlphaFold DB: A0A0E0XS49

Antitoxin

• AlphaFold DB: A0A0E0XTQ1