Detailed information of TA system TA062887

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): prpT-prpA/CC2985(antitoxin)
• Location: 2377457..2377997
• Replicon: chromosome
• Accession: NZ_CP015344
• Organism: Legionella pneumophila strain D-7630

Toxin (Protein)

• Gene name: PrpT
• Uniprot ID: -
• Locus tag: A5479_RS10700
• Protein ID: WP_014844324.1
• Coordinates: 2377701..2377997 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: PrpA
• Uniprot ID: -
• Locus tag: A5479_RS10695
• Protein ID: WP_027224835.1
• Coordinates: 2377457..2377711 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A5479_RS10675	2373361..2374536	-	1176	WP_027224832.1	ISL3 family transposase	-
A5479_RS10680	2374575..2375705	-	1131	WP_064319116.1	ISL3 family transposase	-
A5479_RS10685	2375860..2376438	+	579	WP_027224833.1	hypothetical protein	-
A5479_RS10690	2376543..2377109	+	567	WP_027224834.1	hypothetical protein	-
A5479_RS10695	2377457..2377711	+	255	WP_027224835.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
A5479_RS10700	2377701..2377997	+	297	WP_014844324.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
A5479_RS10710	2378458..2379472	-	1015	Protein_2098	transposase	-
A5479_RS10715	2379735..2379944	+	210	WP_010947832.1	cold-shock protein	-
A5479_RS10720	2380184..2381590	+	1407	WP_014844326.1	ATP-dependent RNA helicase DbpA	-
A5479_RS10725	2381747..2382658	+	912	WP_014844327.1	cation diffusion facilitator family transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2298321..2378243	79922

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-94)

Antitoxin

• Antitoxin ParD (1-81)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11582.28 Da
• Isoelectric Point: 7.2728

>T62887 WP_014844324.1 NZ_CP015344:2377701-2377997 [Legionella pneumophila]
MSNKTYRLYPKAVEDLESIYLYSTNEFGIKRTEDYILAIDLSFQRLADDPLIARKCDYIRPELRAFNVGSHIIFFKTTDY
GISVIRVLHQSMDFNRHL

Nucleotide

• Length: 297 bp

>T62887 NZ_CP015344:2377701-2377997 [Legionella pneumophila]
ATGTCAAATAAAACATATCGTCTTTACCCAAAAGCGGTAGAAGATCTTGAGTCCATCTATTTATATAGCACAAATGAGTT
TGGTATCAAACGAACAGAGGATTATATTTTAGCTATAGATTTAAGTTTTCAGCGCCTTGCAGATGATCCCTTAATTGCTC
GAAAATGTGATTATATTCGTCCAGAATTACGCGCATTTAATGTTGGCTCTCACATTATTTTTTTCAAAACTACCGATTAC
GGCATTTCTGTTATTCGAGTGTTGCATCAATCTATGGATTTTAATAGACATCTATAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9786.14 Da
• Isoelectric Point: 9.9613

>AT62887 WP_027224835.1 NZ_CP015344:2377457-2377711 [Legionella pneumophila]
MTRTMTVDLGNELRNYVESLVRSGDYRSNSEVLRESLRLLREKQAESKLEQLRHLIDEGAASGKPETWDAHDFLKKMKKK
SHVK

Nucleotide

• Length: 255 bp

>AT62887 NZ_CP015344:2377457-2377711 [Legionella pneumophila]
ATGACCCGTACAATGACTGTTGATTTGGGTAATGAACTTCGTAATTACGTGGAATCACTTGTACGCTCAGGGGATTATAG
AAGTAATAGCGAAGTATTAAGAGAGTCGTTGCGTTTACTTCGTGAAAAACAAGCTGAATCAAAACTAGAGCAGTTGCGTC
ACCTTATAGATGAAGGGGCAGCTAGCGGGAAGCCTGAAACATGGGATGCACATGATTTTCTTAAGAAAATGAAGAAAAAA
TCCCATGTCAAATAA