Detailed information of TA system TA062886

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 68292..69829
• Replicon: chromosome
• Accession: NZ_CP015344
• Organism: Legionella pneumophila strain D-7630

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: A5479_RS00315
• Protein ID: WP_027224673.1
• Coordinates: 68292..69590 (-)
• Length: 433 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: A5479_RS00320
• Protein ID: WP_014840730.1
• Coordinates: 69590..69829 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A5479_RS00285	63777..64496	+	720	WP_014843028.1	C39 family peptidase	-
A5479_RS00290	64532..65092	+	561	WP_011212702.1	hypothetical protein	-
A5479_RS15830	65200..65361	+	162	WP_015444967.1	hypothetical protein	-
A5479_RS00295	65398..65802	-	405	WP_011212703.1	MerR family transcriptional regulator	-
A5479_RS00300	65872..66624	+	753	WP_027224671.1	glutaredoxin family protein	-
A5479_RS00305	66814..67905	+	1092	WP_027224672.1	hypothetical protein	-
A5479_RS00310	67947..68222	+	276	Protein_62	integrase	-
A5479_RS00315	68292..69590	-	1299	WP_027224673.1	HipA domain-containing protein	Toxin
A5479_RS00320	69590..69829	-	240	WP_014840730.1	helix-turn-helix domain-containing protein	Antitoxin
A5479_RS15350	70196..70560	+	365	Protein_65	protein LvrA	-
A5479_RS15355	70670..70942	+	273	WP_032829407.1	hypothetical protein	-
A5479_RS00335	71637..73049	-	1413	WP_027224675.1	hypothetical protein	-
A5479_RS00340	73080..73688	-	609	WP_027224676.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (148-398)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 433 a.a.
• Molecular weight: 49473.80 Da
• Isoelectric Point: 8.2954

>T62886 WP_027224673.1 NZ_CP015344:c69590-68292 [Legionella pneumophila]
MRKLYILMNNELVGELTQDNAGGLSFSYVADWISKPHSRPVSLSLPLVNQKFSGEVVYNFFDNLLPDNPQIRARIQARFQ
AKSSRPFDLLALIGSDCVGAIQIVERIPQTQRLSIESHVVSEAEIARTLRSYQTSPLGMDKEDDEFRISIAGAQEKTAFL
YYQNEWHKPFGPTPTTHIFKLPIGYLPHQGIDLSESCENEHLCLLLASKFGLDVAKSKILQFEDEKVLVVERFDRKWSRD
NRYILRLPQEDLCQALGYSPNLKYQSDGGPGIKEIMQLLNGSQQPQKDRDEFFRAQVVYWCLGAIDAHAKNFSISIQPQG
GYQLTPLYDIISAYPIVEQKQLSFKKLKMAMALYGKNIHYKIDGIQKRHFIETAKYVKYSKIKAAQIFEQVIDRIDSAID
EVSRQLPNHFPEKIADPIFKGMRAFKERMIST

Nucleotide

• Length: 1299 bp

>T62886 NZ_CP015344:c69590-68292 [Legionella pneumophila]
ATGCGTAAATTATACATATTGATGAACAATGAGCTCGTGGGGGAGCTTACCCAGGATAATGCAGGTGGTTTGAGTTTTTC
CTACGTTGCTGACTGGATTTCCAAACCGCATTCACGCCCAGTTTCTTTATCGTTACCGTTAGTAAATCAAAAATTTTCAG
GAGAAGTTGTTTATAACTTTTTTGATAATTTACTTCCCGATAATCCACAGATAAGAGCCAGAATTCAAGCTCGTTTTCAG
GCAAAATCATCGCGACCGTTTGATTTATTGGCGTTAATTGGCAGTGATTGTGTTGGTGCAATACAAATTGTTGAACGTAT
TCCTCAGACACAGCGTCTAAGCATTGAAAGTCACGTTGTCAGTGAGGCCGAGATAGCTCGTACTTTACGTTCTTACCAAA
CCTCACCACTGGGAATGGATAAAGAGGATGATGAGTTTAGAATCTCAATAGCCGGTGCTCAGGAAAAAACGGCTTTTCTA
TATTACCAAAATGAATGGCATAAACCATTTGGACCTACACCAACAACTCACATATTCAAATTACCTATTGGATATTTACC
ACATCAAGGAATTGATTTAAGTGAGAGTTGTGAAAATGAGCATCTCTGTTTACTACTAGCCAGCAAATTTGGTTTAGATG
TTGCAAAATCAAAAATCTTACAATTCGAAGATGAAAAAGTGCTGGTTGTCGAAAGATTTGATAGAAAATGGAGTCGAGAT
AACCGTTATATACTCAGGTTACCGCAAGAAGACCTATGCCAAGCGTTGGGTTATTCACCAAATTTAAAATATCAGTCAGA
TGGTGGCCCCGGTATTAAAGAAATTATGCAGCTACTTAATGGCTCACAGCAGCCTCAAAAAGACAGAGATGAATTTTTCA
GAGCACAAGTTGTTTACTGGTGCCTTGGTGCTATTGATGCGCATGCCAAAAATTTCAGTATAAGTATACAACCACAAGGC
GGTTACCAGCTCACCCCCTTATACGACATCATTTCAGCCTATCCTATCGTGGAACAAAAACAGCTATCCTTTAAGAAATT
GAAAATGGCAATGGCTTTATATGGTAAAAATATTCATTACAAGATTGACGGTATTCAAAAAAGACACTTTATTGAAACAG
CAAAATACGTTAAATATTCTAAAATTAAAGCAGCTCAGATTTTTGAACAAGTGATTGACCGTATTGATTCTGCTATCGAT
GAGGTCTCAAGACAATTACCAAACCACTTCCCAGAAAAGATTGCAGATCCAATCTTCAAAGGGATGAGAGCTTTTAAGGA
GCGAATGATATCCACATAG

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 9096.40 Da
• Isoelectric Point: 5.0774

>AT62886 WP_014840730.1 NZ_CP015344:c69829-69590 [Legionella pneumophila]
MIISSAKDLALYLNDKRKQLKMSQSEVADLVGLKQDTISKFENSPDNSRIDTLFRILSALNLNMSLVEKDQKTHEEIEW

Nucleotide

• Length: 240 bp

>AT62886 NZ_CP015344:c69829-69590 [Legionella pneumophila]
ATGATCATTAGCTCAGCAAAAGATTTAGCATTATATTTAAATGACAAGCGCAAACAACTCAAAATGAGTCAATCTGAAGT
TGCCGATTTAGTCGGCTTAAAACAGGATACCATATCAAAGTTTGAAAATAGCCCCGATAATAGTCGAATTGATACCTTAT
TTAGAATATTGTCCGCCCTAAATTTAAATATGAGCCTTGTTGAAAAAGATCAAAAAACTCATGAAGAGATAGAATGGTAA