Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prpT-prpA/CC2985(antitoxin)
Location 2366239..2366779 Replicon chromosome
Accession NZ_CP015342
Organism Legionella pneumophila strain D-7632

Toxin (Protein)


Gene name PrpT Uniprot ID -
Locus tag A5478_RS10640 Protein ID WP_014844324.1
Coordinates 2366483..2366779 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name PrpA Uniprot ID -
Locus tag A5478_RS10635 Protein ID WP_027224835.1
Coordinates 2366239..2366493 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A5478_RS10615 2362143..2363318 - 1176 WP_027224832.1 ISL3 family transposase -
A5478_RS10620 2363357..2364487 - 1131 WP_064319116.1 ISL3 family transposase -
A5478_RS10625 2364642..2365220 + 579 WP_027224833.1 hypothetical protein -
A5478_RS10630 2365325..2365891 + 567 WP_027224834.1 hypothetical protein -
A5478_RS10635 2366239..2366493 + 255 WP_027224835.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
A5478_RS10640 2366483..2366779 + 297 WP_014844324.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A5478_RS10650 2367240..2368254 - 1015 Protein_2086 transposase -
A5478_RS10655 2368517..2368726 + 210 WP_010947832.1 cold-shock protein -
A5478_RS10660 2368966..2370372 + 1407 WP_014844326.1 ATP-dependent RNA helicase DbpA -
A5478_RS10665 2370529..2371440 + 912 WP_014844327.1 cation diffusion facilitator family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2297781..2367025 69244


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-94)

Antitoxin

Antitoxin ParD

(1-81)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11582.28 Da        Isoelectric Point: 7.2728

>T62881 WP_014844324.1 NZ_CP015342:2366483-2366779 [Legionella pneumophila]
MSNKTYRLYPKAVEDLESIYLYSTNEFGIKRTEDYILAIDLSFQRLADDPLIARKCDYIRPELRAFNVGSHIIFFKTTDY
GISVIRVLHQSMDFNRHL

Download         Length: 297 bp

>T62881 NZ_CP015342:2366483-2366779 [Legionella pneumophila]
ATGTCAAATAAAACATATCGTCTTTACCCAAAAGCGGTAGAAGATCTTGAGTCCATCTATTTATATAGCACAAATGAGTT
TGGTATCAAACGAACAGAGGATTATATTTTAGCTATAGATTTAAGTTTTCAGCGCCTTGCAGATGATCCCTTAATTGCTC
GAAAATGTGATTATATTCGTCCAGAATTACGCGCATTTAATGTTGGCTCTCACATTATTTTTTTCAAAACTACCGATTAC
GGCATTTCTGTTATTCGAGTGTTGCATCAATCTATGGATTTTAATAGACATCTATAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9786.14 Da        Isoelectric Point: 9.9613

>AT62881 WP_027224835.1 NZ_CP015342:2366239-2366493 [Legionella pneumophila]
MTRTMTVDLGNELRNYVESLVRSGDYRSNSEVLRESLRLLREKQAESKLEQLRHLIDEGAASGKPETWDAHDFLKKMKKK
SHVK

Download         Length: 255 bp

>AT62881 NZ_CP015342:2366239-2366493 [Legionella pneumophila]
ATGACCCGTACAATGACTGTTGATTTGGGTAATGAACTTCGTAATTACGTGGAATCACTTGTACGCTCAGGGGATTATAG
AAGTAATAGCGAAGTATTAAGAGAGTCGTTGCGTTTACTTCGTGAAAAACAAGCTGAATCAAAACTAGAGCAGTTGCGTC
ACCTTATAGATGAAGGGGCAGCTAGCGGGAAGCCTGAAACATGGGATGCACATGATTTTCTTAAGAAAATGAAGAAAAAA
TCCCATGTCAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References