Detailed information of TA system TA062868

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 192828..193287
• Replicon: chromosome
• Accession: NZ_CP015282
• Organism: Streptococcus salivarius strain ATCC 27945

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: NX99_RS00455
• Protein ID: WP_084914362.1
• Coordinates: 193033..193287 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: F8HC66
• Locus tag: NX99_RS00450
• Protein ID: WP_014632927.1
• Coordinates: 192828..193043 (+)
• Length: 72 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NX99_RS00440	190674..191759	+	1086	WP_084915476.1	hypothetical protein	-
NX99_RS00445	191853..192695	+	843	WP_084914361.1	aldo/keto reductase	-
NX99_RS00450	192828..193043	+	216	WP_014632927.1	hypothetical protein	Antitoxin
NX99_RS00455	193033..193287	+	255	WP_084914362.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
NX99_RS00460	193431..194117	+	687	WP_004182263.1	DUF1275 domain-containing protein	-
NX99_RS00465	194208..194840	+	633	WP_084914364.1	nitroreductase family protein	-
NX99_RS00470	195003..195686	+	684	WP_084914365.1	response regulator transcription factor	-
NX99_RS00475	195686..196561	+	876	WP_084914366.1	HAMP domain-containing histidine kinase	-
NX99_RS00480	196846..197355	+	510	WP_084914367.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-84)

Antitoxin

• Protein of unknown function DUF6290 (1-57)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9919.66 Da
• Isoelectric Point: 11.1183

>T62868 WP_084914362.1 NZ_CP015282:193033-193287 [Streptococcus salivarius]
MTYKIVPTPKFAKNFKKLDPFVRKQIKSYLNRVTDNPRAKGKTLVANRTGQWRYRIGAYRVIVNIQDNELIILALEVGHR
RDIY

Nucleotide

• Length: 255 bp

>T62868 NZ_CP015282:193033-193287 [Streptococcus salivarius]
ATGACCTATAAGATAGTACCCACCCCTAAATTTGCCAAAAATTTTAAAAAGTTGGATCCTTTCGTCAGAAAACAAATTAA
GTCTTATCTCAATCGTGTCACAGATAATCCAAGAGCCAAGGGTAAGACCTTGGTTGCCAATCGCACTGGACAATGGCGCT
ATCGTATTGGTGCCTATCGTGTTATTGTCAATATTCAGGACAATGAACTAATCATACTTGCCCTCGAAGTCGGTCATAGA
CGTGATATCTATTAG

Antitoxin

Protein

• Length: 72 a.a.
• Molecular weight: 8031.00 Da
• Isoelectric Point: 3.8964

>AT62868 WP_014632927.1 NZ_CP015282:192828-193043 [Streptococcus salivarius]
MTTITLKVSEADKKFMQAIAKFEGVSLSELIRTKTLEAIEDEYDARVADLALAEYEDYLENGGEVLNWDDL

Nucleotide

• Length: 216 bp

>AT62868 NZ_CP015282:192828-193043 [Streptococcus salivarius]
ATGACAACAATTACATTGAAGGTTTCAGAGGCAGATAAGAAGTTCATGCAGGCCATTGCGAAATTTGAAGGGGTATCCTT
GTCAGAATTAATTCGTACCAAAACTTTAGAAGCCATTGAGGATGAATATGACGCTAGAGTAGCCGATTTGGCTTTGGCAG
AATATGAAGACTATCTTGAAAATGGTGGGGAGGTGCTAAATTGGGATGACCTATAA

Structures

Antitoxin

• AlphaFold DB: F8HC66