Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4188319..4188982 Replicon chromosome
Accession NZ_CP015281
Organism Photorhabdus laumondii subsp. laumondii strain DSPV002N

Toxin (Protein)


Gene name cptA Uniprot ID Q7N1C2
Locus tag A4R40_RS18290 Protein ID WP_011147734.1
Coordinates 4188319..4188735 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q7N1C1
Locus tag A4R40_RS18295 Protein ID WP_011147735.1
Coordinates 4188716..4188982 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4R40_RS18270 4184296..4186029 - 1734 WP_011147730.1 single-stranded-DNA-specific exonuclease RecJ -
A4R40_RS18275 4186029..4186736 - 708 WP_011147731.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
A4R40_RS18280 4186760..4187671 - 912 WP_011147732.1 site-specific tyrosine recombinase XerD -
A4R40_RS18285 4187779..4188297 + 519 WP_041380273.1 flavodoxin FldB -
A4R40_RS18290 4188319..4188735 - 417 WP_011147734.1 protein YgfX Toxin
A4R40_RS18295 4188716..4188982 - 267 WP_011147735.1 FAD assembly factor SdhE Antitoxin
A4R40_RS18300 4189160..4190149 + 990 WP_011147736.1 tRNA-modifying protein YgfZ -
A4R40_RS18305 4190161..4190766 + 606 WP_011147737.1 HD domain-containing protein -
A4R40_RS18310 4191698..4193002 - 1305 WP_011147738.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-135)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 16363.34 Da        Isoelectric Point: 10.1464

>T62855 WP_011147734.1 NZ_CP015281:c4188735-4188319 [Photorhabdus laumondii subsp. laumondii]
VVLWKCDLRVSWHTQLISTCVHGAIALIVLFAPWPADDAIFWIFWLPLVLLIIASWGRSQKNIRKSQGLLVLLSDNKLQW
KKHEWQIIRRPWLCRYGVLITAQSFYNQKKIRLWVASDGMPQDEWRNINQLLLQYPDI

Download         Length: 417 bp

>T62855 NZ_CP015281:c4188735-4188319 [Photorhabdus laumondii subsp. laumondii]
GTGGTCCTGTGGAAGTGTGATCTCAGGGTATCTTGGCATACCCAGCTAATTTCTACCTGTGTTCATGGTGCAATAGCGCT
TATCGTACTATTTGCTCCGTGGCCTGCGGATGACGCTATTTTCTGGATTTTCTGGCTTCCTTTGGTACTGTTGATTATTG
CCAGTTGGGGGCGTAGCCAGAAAAATATCCGTAAATCTCAAGGGCTTTTAGTTCTTCTCAGTGATAATAAGTTGCAATGG
AAGAAGCATGAGTGGCAAATTATCCGGCGGCCGTGGTTGTGTCGTTATGGCGTATTAATTACGGCTCAATCTTTTTATAA
CCAGAAAAAAATCCGTTTATGGGTCGCATCCGATGGTATGCCACAGGATGAATGGAGGAATATTAATCAACTGTTGTTGC
AATATCCTGATATCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10645.25 Da        Isoelectric Point: 5.7258

>AT62855 WP_011147735.1 NZ_CP015281:c4188982-4188716 [Photorhabdus laumondii subsp. laumondii]
MDIDNKARIHWACRRGMRELDISIMPFFKYEYDSLSDDDKRLFIRLLACADPDLFNWLMNHGRPEDEELFRMIKLIQNRN
KDRGPVEV

Download         Length: 267 bp

>AT62855 NZ_CP015281:c4188982-4188716 [Photorhabdus laumondii subsp. laumondii]
ATGGATATTGATAATAAAGCGCGTATTCATTGGGCATGTCGGCGTGGAATGCGTGAGCTGGATATTTCAATTATGCCGTT
TTTTAAGTATGAATATGACTCACTCAGTGATGATGATAAACGACTTTTTATTCGCTTACTTGCATGTGCTGATCCTGATC
TATTCAACTGGCTAATGAATCATGGGCGTCCAGAAGATGAAGAGTTATTTCGCATGATTAAACTTATTCAGAATAGAAAT
AAAGATCGTGGTCCTGTGGAAGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6L9JK22

Antitoxin

Source ID Structure
AlphaFold DB A0A6L9JKF1

References