Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 3792542..3793503 Replicon chromosome
Accession NZ_CP015281
Organism Photorhabdus laumondii subsp. laumondii strain DSPV002N

Toxin (Protein)


Gene name panT Uniprot ID Q7N276
Locus tag A4R40_RS16600 Protein ID WP_011147419.1
Coordinates 3792542..3792943 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID Q7N275
Locus tag A4R40_RS16605 Protein ID WP_011147420.1
Coordinates 3792943..3793503 (-) Length 187 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4R40_RS16590 3788968..3789984 - 1017 WP_011147417.1 formamidase -
A4R40_RS16595 3790470..3792023 + 1554 WP_011147418.1 Fic family protein -
A4R40_RS16600 3792542..3792943 - 402 WP_011147419.1 hypothetical protein Toxin
A4R40_RS16605 3792943..3793503 - 561 WP_011147420.1 SocA family protein Antitoxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 3787539..3788477 938


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(27-140)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15019.47 Da        Isoelectric Point: 7.6242

>T62853 WP_011147419.1 NZ_CP015281:c3792943-3792542 [Photorhabdus laumondii subsp. laumondii]
MPGGILRKGSLLIPSGYTDHLYIICCDPVFYPKKTKTCFLAVNISSLKLDIPYDRTCILNCGDHPFIRHPSFVFYGRADI
FGSVTVEQHMAAGDIKIHEPCGDSVFDRILSGFDISPHVTLEIRNFYKKYCIN

Download         Length: 402 bp

>T62853 NZ_CP015281:c3792943-3792542 [Photorhabdus laumondii subsp. laumondii]
ATGCCGGGTGGGATTTTAAGGAAAGGAAGTTTACTTATCCCATCTGGATATACAGATCACTTATATATTATCTGCTGTGA
TCCAGTTTTTTACCCTAAAAAAACGAAGACATGTTTTTTGGCTGTAAATATTAGCTCTTTAAAACTGGACATACCGTATG
ATCGAACGTGTATATTGAATTGTGGCGATCATCCTTTTATTAGACATCCGAGTTTTGTTTTCTATGGTCGCGCTGATATT
TTTGGCTCAGTAACCGTTGAACAGCATATGGCTGCTGGTGATATTAAAATCCATGAACCATGTGGTGATTCTGTTTTTGA
TCGGATTCTTTCTGGGTTTGATATATCTCCGCATGTAACTTTAGAAATTAGAAATTTCTATAAAAAATATTGTATTAACT
GA

Antitoxin


Download         Length: 187 a.a.        Molecular weight: 21270.30 Da        Isoelectric Point: 4.9174

>AT62853 WP_011147420.1 NZ_CP015281:c3793503-3792943 [Photorhabdus laumondii subsp. laumondii]
MFCEEKVAQMAAYLLYKRGGRMAYLKLMKLLYLADRVSMNDYGYPITGDRMVSMPRGPVLSQTLNLITGDYASDEFGWGA
WIKSEKNYEISLKRKGITRDDFESLSDAELEVLDAIWEQFGHMSRFDIVEYTHKHCTEWQDPGGSSYPISPSSVFIAVGK
SPEVAEKLAQELIERQQLDCFLQGLR

Download         Length: 561 bp

>AT62853 NZ_CP015281:c3793503-3792943 [Photorhabdus laumondii subsp. laumondii]
ATGTTTTGCGAAGAAAAAGTAGCCCAAATGGCTGCCTACTTGCTGTATAAGCGCGGCGGGCGCATGGCATATCTGAAGCT
TATGAAGTTGCTTTATCTGGCAGATAGGGTATCTATGAATGACTATGGCTATCCTATCACTGGCGATCGAATGGTATCTA
TGCCGAGAGGGCCAGTTTTATCGCAAACCTTAAATTTAATTACTGGAGATTACGCCAGTGATGAATTTGGGTGGGGGGCA
TGGATTAAAAGTGAAAAGAATTATGAAATTTCACTCAAACGGAAAGGTATAACAAGGGATGATTTTGAATCTCTTTCTGA
TGCTGAATTAGAAGTTCTGGATGCCATTTGGGAACAATTCGGTCATATGAGCCGCTTTGATATTGTGGAGTATACCCATA
AACATTGTACTGAGTGGCAAGATCCAGGCGGCAGTTCTTATCCTATTTCACCAAGTTCTGTTTTTATTGCTGTCGGTAAA
TCACCAGAAGTTGCTGAGAAATTGGCGCAAGAGTTAATAGAAAGGCAACAACTGGACTGTTTTCTTCAAGGATTGCGGTG
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6L9JWG9

Antitoxin

Source ID Structure
AlphaFold DB A0A6L9JW02

References