Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 3561554..3562209 Replicon chromosome
Accession NZ_CP015281
Organism Photorhabdus laumondii subsp. laumondii strain DSPV002N

Toxin (Protein)


Gene name vapC Uniprot ID Q7N2L9
Locus tag A4R40_RS15780 Protein ID WP_011147274.1
Coordinates 3561554..3561973 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q7N2L8
Locus tag A4R40_RS15785 Protein ID WP_011147275.1
Coordinates 3561970..3562209 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4R40_RS15755 3556572..3558863 + 2292 WP_011147269.1 ribonucleoside-diphosphate reductase subunit alpha -
A4R40_RS15760 3558876..3560006 + 1131 WP_011147270.1 ribonucleotide-diphosphate reductase subunit beta -
A4R40_RS15765 3560006..3560272 + 267 WP_011147271.1 2Fe-2S ferredoxin-like protein -
A4R40_RS15770 3560394..3560774 - 381 WP_011147272.1 type II toxin-antitoxin system YafO family toxin -
A4R40_RS15775 3560774..3561394 - 621 WP_041380171.1 hypothetical protein -
A4R40_RS15780 3561554..3561973 - 420 WP_011147274.1 type II toxin-antitoxin system VapC family toxin Toxin
A4R40_RS15785 3561970..3562209 - 240 WP_011147275.1 Arc family DNA-binding protein Antitoxin
A4R40_RS15790 3562539..3563552 + 1014 WP_041380173.1 Gfo/Idh/MocA family oxidoreductase -
A4R40_RS15795 3563794..3564300 - 507 WP_011147276.1 CdiI family contact-dependent growth inhibition immunity protein -
A4R40_RS15800 3564464..3564970 - 507 WP_011147277.1 CdiI family contact-dependent growth inhibition immunity protein -
A4R40_RS15805 3565134..3565634 - 501 WP_011147278.1 CdiI family contact-dependent growth inhibition immunity protein -
A4R40_RS15810 3565634..3565978 - 345 WP_011147279.1 hypothetical protein -
A4R40_RS15815 3566205..3566741 - 537 WP_011147280.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Arc-like DNA binding domain

(5-46)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14785.05 Da        Isoelectric Point: 6.4726

>T62852 WP_011147274.1 NZ_CP015281:c3561973-3561554 [Photorhabdus laumondii subsp. laumondii]
MILLDTNVVSEPLRLSGHPAVVAWIDEQNVETLYLAAISLAELRFGVAALSNGKRKDTLHRNLERSVVPLFTGRILPFDA
AASEAYAEIMARAKSEGKAIGKADGYIAAIAAANGLIVATRDISPFEAAGLTVINPWKG

Download         Length: 420 bp

>T62852 NZ_CP015281:c3561973-3561554 [Photorhabdus laumondii subsp. laumondii]
ATGATACTGCTAGATACGAACGTGGTTTCCGAGCCACTGCGGCTCAGCGGCCACCCCGCTGTGGTTGCCTGGATAGATGA
ACAGAATGTCGAGACGCTTTACTTGGCAGCGATCAGCTTGGCTGAGCTTCGCTTTGGGGTTGCAGCGCTGTCCAATGGTA
AGCGCAAAGATACCCTGCATAGAAACCTAGAGCGGAGTGTTGTTCCTTTATTTACCGGTCGTATCTTGCCATTCGATGCG
GCCGCTTCGGAAGCTTATGCCGAGATCATGGCGCGAGCGAAGAGCGAGGGGAAAGCCATTGGGAAGGCTGACGGGTATAT
TGCGGCTATTGCAGCGGCGAATGGGCTGATTGTTGCAACCCGCGACATATCACCTTTTGAAGCTGCCGGGCTTACTGTTA
TCAACCCTTGGAAGGGCTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8776.01 Da        Isoelectric Point: 5.7268

>AT62852 WP_011147275.1 NZ_CP015281:c3562209-3561970 [Photorhabdus laumondii subsp. laumondii]
MPSITVRNVPDEVHRALRVRAATHGRSAEAEIRFILENAVQPEGRIKLGSLLAKIGREAEGVDLEIERDKTPAEPMSFE

Download         Length: 240 bp

>AT62852 NZ_CP015281:c3562209-3561970 [Photorhabdus laumondii subsp. laumondii]
ATGCCATCCATTACTGTCAGAAATGTACCGGACGAAGTGCATCGTGCCTTGCGGGTACGCGCAGCCACACATGGCCGTAG
TGCTGAGGCCGAAATCCGGTTTATTCTGGAAAACGCCGTACAACCGGAGGGGCGCATCAAGCTGGGTTCCTTGCTGGCAA
AAATCGGCCGCGAGGCGGAGGGCGTCGATCTTGAGATCGAGCGTGATAAGACACCTGCTGAGCCGATGAGTTTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6L9JKK2

Antitoxin

Source ID Structure
AlphaFold DB A0A6L9JKY2

References