Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapB(antitoxin)
Location 2785138..2785718 Replicon chromosome
Accession NZ_CP015281
Organism Photorhabdus laumondii subsp. laumondii strain DSPV002N

Toxin (Protein)


Gene name vapC Uniprot ID Q7N4G9
Locus tag A4R40_RS12205 Protein ID WP_011146604.1
Coordinates 2785138..2785515 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q7N4G8
Locus tag A4R40_RS12210 Protein ID WP_011146605.1
Coordinates 2785515..2785718 (-) Length 68 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4R40_RS12180 2780293..2781840 + 1548 WP_109791577.1 YdgA family protein -
A4R40_RS12185 2781918..2782919 + 1002 WP_011146598.1 adenosine deaminase -
A4R40_RS26030 2783089..2783202 + 114 WP_173362526.1 hypothetical protein -
A4R40_RS12190 2783218..2783634 + 417 WP_165828667.1 plasmid pRiA4b ORF-3 family protein -
A4R40_RS12195 2783708..2783830 - 123 Protein_2325 peptidase -
A4R40_RS12200 2783920..2784321 - 402 WP_154097930.1 type II toxin-antitoxin system PemK/MazF family toxin -
A4R40_RS25475 2784254..2784511 - 258 WP_011146602.1 antitoxin -
A4R40_RS12205 2785138..2785515 - 378 WP_011146604.1 type II toxin-antitoxin system VapC family toxin Toxin
A4R40_RS12210 2785515..2785718 - 204 WP_011146605.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
A4R40_RS12215 2785817..2785977 + 161 Protein_2330 IS5/IS1182 family transposase -
A4R40_RS12220 2786057..2786521 + 465 WP_011146606.1 hypothetical protein -
A4R40_RS12225 2786539..2786838 + 300 WP_011146607.1 type II toxin-antitoxin system RelE/ParE family toxin -
A4R40_RS12230 2787355..2787636 - 282 WP_011146608.1 hypothetical protein -
A4R40_RS12235 2788072..2789043 - 972 WP_058588680.1 bile acid:sodium symporter -
A4R40_RS12240 2789252..2790289 - 1038 WP_058588681.1 oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-44)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13907.45 Da        Isoelectric Point: 7.3226

>T62849 WP_011146604.1 NZ_CP015281:c2785515-2785138 [Photorhabdus laumondii subsp. laumondii]
MTILVDTSVWIDHFKNRNDGLIQLLSRDLVLIHPMILAEIACGTPLAPRLRTLGDLGLLPQSHQATIIEVMAFIENEKLY
GLGCGLVDITLLASTLITPGARLWTLDKRLEKLAKRLNASYQPIH

Download         Length: 378 bp

>T62849 NZ_CP015281:c2785515-2785138 [Photorhabdus laumondii subsp. laumondii]
ATGACTATTTTAGTAGATACGTCCGTCTGGATTGACCATTTCAAAAACAGGAATGACGGATTGATCCAGTTGTTAAGCCG
GGATCTGGTTCTGATTCATCCGATGATACTGGCTGAAATAGCCTGTGGTACTCCTCTGGCACCAAGACTGCGAACGCTTG
GAGATCTGGGGCTGTTACCACAGAGTCATCAGGCCACTATCATCGAGGTAATGGCATTCATTGAAAACGAAAAGTTGTAC
GGCCTCGGATGTGGTCTGGTTGATATTACATTGCTGGCATCAACCTTGATAACACCAGGGGCAAGGCTTTGGACGCTGGA
TAAACGACTTGAGAAGTTGGCTAAACGTCTTAATGCGAGTTATCAGCCGATTCATTGA

Antitoxin


Download         Length: 68 a.a.        Molecular weight: 7424.51 Da        Isoelectric Point: 6.2644

>AT62849 WP_011146605.1 NZ_CP015281:c2785718-2785515 [Photorhabdus laumondii subsp. laumondii]
MRTTVTIDDALYAQALEMADPGMDKADIFREAVKTFVRVQAAKRLASLGSTSPDMQIVPRRREEPSA

Download         Length: 204 bp

>AT62849 NZ_CP015281:c2785718-2785515 [Photorhabdus laumondii subsp. laumondii]
ATGCGAACTACTGTCACGATTGATGATGCGTTGTATGCACAGGCACTAGAAATGGCCGATCCTGGCATGGATAAGGCTGA
TATTTTCCGTGAAGCGGTGAAAACGTTTGTTCGGGTGCAGGCAGCAAAAAGACTGGCTTCGCTCGGCAGCACATCACCTG
ATATGCAGATAGTTCCCCGTCGCCGGGAGGAGCCATCCGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6L9JG72

Antitoxin

Source ID Structure
AlphaFold DB A0A6L9JFL4

References