Detailed information of TA system TA062849

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapB(antitoxin)
• Location: 2785138..2785718
• Replicon: chromosome
• Accession: NZ_CP015281
• Organism: Photorhabdus laumondii subsp. laumondii strain DSPV002N

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: Q7N4G9
• Locus tag: A4R40_RS12205
• Protein ID: WP_011146604.1
• Coordinates: 2785138..2785515 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: Q7N4G8
• Locus tag: A4R40_RS12210
• Protein ID: WP_011146605.1
• Coordinates: 2785515..2785718 (-)
• Length: 68 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A4R40_RS12180	2780293..2781840	+	1548	WP_109791577.1	YdgA family protein	-
A4R40_RS12185	2781918..2782919	+	1002	WP_011146598.1	adenosine deaminase	-
A4R40_RS26030	2783089..2783202	+	114	WP_173362526.1	hypothetical protein	-
A4R40_RS12190	2783218..2783634	+	417	WP_165828667.1	plasmid pRiA4b ORF-3 family protein	-
A4R40_RS12195	2783708..2783830	-	123	Protein_2325	peptidase	-
A4R40_RS12200	2783920..2784321	-	402	WP_154097930.1	type II toxin-antitoxin system PemK/MazF family toxin	-
A4R40_RS25475	2784254..2784511	-	258	WP_011146602.1	antitoxin	-
A4R40_RS12205	2785138..2785515	-	378	WP_011146604.1	type II toxin-antitoxin system VapC family toxin	Toxin
A4R40_RS12210	2785515..2785718	-	204	WP_011146605.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
A4R40_RS12215	2785817..2785977	+	161	Protein_2330	IS5/IS1182 family transposase	-
A4R40_RS12220	2786057..2786521	+	465	WP_011146606.1	hypothetical protein	-
A4R40_RS12225	2786539..2786838	+	300	WP_011146607.1	type II toxin-antitoxin system RelE/ParE family toxin	-
A4R40_RS12230	2787355..2787636	-	282	WP_011146608.1	hypothetical protein	-
A4R40_RS12235	2788072..2789043	-	972	WP_058588680.1	bile acid:sodium symporter	-
A4R40_RS12240	2789252..2790289	-	1038	WP_058588681.1	oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-44)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13907.45 Da
• Isoelectric Point: 7.3226

>T62849 WP_011146604.1 NZ_CP015281:c2785515-2785138 [Photorhabdus laumondii subsp. laumondii]
MTILVDTSVWIDHFKNRNDGLIQLLSRDLVLIHPMILAEIACGTPLAPRLRTLGDLGLLPQSHQATIIEVMAFIENEKLY
GLGCGLVDITLLASTLITPGARLWTLDKRLEKLAKRLNASYQPIH

Nucleotide

• Length: 378 bp

>T62849 NZ_CP015281:c2785515-2785138 [Photorhabdus laumondii subsp. laumondii]
ATGACTATTTTAGTAGATACGTCCGTCTGGATTGACCATTTCAAAAACAGGAATGACGGATTGATCCAGTTGTTAAGCCG
GGATCTGGTTCTGATTCATCCGATGATACTGGCTGAAATAGCCTGTGGTACTCCTCTGGCACCAAGACTGCGAACGCTTG
GAGATCTGGGGCTGTTACCACAGAGTCATCAGGCCACTATCATCGAGGTAATGGCATTCATTGAAAACGAAAAGTTGTAC
GGCCTCGGATGTGGTCTGGTTGATATTACATTGCTGGCATCAACCTTGATAACACCAGGGGCAAGGCTTTGGACGCTGGA
TAAACGACTTGAGAAGTTGGCTAAACGTCTTAATGCGAGTTATCAGCCGATTCATTGA

Antitoxin

Protein

• Length: 68 a.a.
• Molecular weight: 7424.51 Da
• Isoelectric Point: 6.2644

>AT62849 WP_011146605.1 NZ_CP015281:c2785718-2785515 [Photorhabdus laumondii subsp. laumondii]
MRTTVTIDDALYAQALEMADPGMDKADIFREAVKTFVRVQAAKRLASLGSTSPDMQIVPRRREEPSA

Nucleotide

• Length: 204 bp

>AT62849 NZ_CP015281:c2785718-2785515 [Photorhabdus laumondii subsp. laumondii]
ATGCGAACTACTGTCACGATTGATGATGCGTTGTATGCACAGGCACTAGAAATGGCCGATCCTGGCATGGATAAGGCTGA
TATTTTCCGTGAAGCGGTGAAAACGTTTGTTCGGGTGCAGGCAGCAAAAAGACTGGCTTCGCTCGGCAGCACATCACCTG
ATATGCAGATAGTTCCCCGTCGCCGGGAGGAGCCATCCGCATAA

Structures

Toxin

• AlphaFold DB: A0A6L9JG72

Antitoxin

• AlphaFold DB: A0A6L9JFL4