Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-TIGR02293 |
| Location | 2776301..2777214 | Replicon | chromosome |
| Accession | NZ_CP015281 | ||
| Organism | Photorhabdus laumondii subsp. laumondii strain DSPV002N | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | Q7N4H9 |
| Locus tag | A4R40_RS12165 | Protein ID | WP_011146594.1 |
| Coordinates | 2776744..2777214 (+) | Length | 157 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | Q7N4I0 |
| Locus tag | A4R40_RS12160 | Protein ID | WP_011146593.1 |
| Coordinates | 2776301..2776747 (+) | Length | 149 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| A4R40_RS12140 | 2771595..2772194 | + | 600 | WP_011146588.1 | lytic polysaccharide monooxygenase | - |
| A4R40_RS12145 | 2772415..2773527 | - | 1113 | WP_011146589.1 | class II histone deacetylase | - |
| A4R40_RS12150 | 2774020..2774487 | - | 468 | WP_011146591.1 | hypothetical protein | - |
| A4R40_RS12155 | 2775302..2776228 | + | 927 | WP_011146592.1 | DNA replication terminus site-binding protein | - |
| A4R40_RS12160 | 2776301..2776747 | + | 447 | WP_011146593.1 | type II toxin-antitoxin system antitoxin Xre | Antitoxin |
| A4R40_RS12165 | 2776744..2777214 | + | 471 | WP_011146594.1 | type II toxin-antitoxin system NAD+ phosphorylase toxin Res | Toxin |
| A4R40_RS12170 | 2777282..2778676 | - | 1395 | WP_011146595.1 | class II fumarate hydratase | - |
| A4R40_RS12175 | 2778981..2780153 | + | 1173 | WP_011146596.1 | mannose-6-phosphate isomerase | - |
| A4R40_RS12180 | 2780293..2781840 | + | 1548 | WP_109791577.1 | YdgA family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17341.92 Da Isoelectric Point: 5.1801
>T62848 WP_011146594.1 NZ_CP015281:2776744-2777214 [Photorhabdus laumondii subsp. laumondii]
VILYRLTRSKYVESAWSGTGAKLYGGRWHNIGRPAVYVATSVSLAVLEVLVHVGDDELLTDFALLSIDIPENQIDILDID
TLPSDWNAPVPSTCTMEIGSEWFEVSHSIGLVVPSAIVPYENNVILNPMAKDFHKYINTVKRLDFGIDSRLVKAKK
VILYRLTRSKYVESAWSGTGAKLYGGRWHNIGRPAVYVATSVSLAVLEVLVHVGDDELLTDFALLSIDIPENQIDILDID
TLPSDWNAPVPSTCTMEIGSEWFEVSHSIGLVVPSAIVPYENNVILNPMAKDFHKYINTVKRLDFGIDSRLVKAKK
Download Length: 471 bp
>T62848 NZ_CP015281:2776744-2777214 [Photorhabdus laumondii subsp. laumondii]
GTGATCTTATACCGACTTACCCGTTCAAAATATGTCGAATCAGCATGGAGTGGTACAGGAGCAAAGTTATATGGTGGCCG
TTGGCACAATATAGGAAGACCCGCAGTTTATGTAGCCACTTCAGTTTCTCTTGCTGTGCTAGAAGTACTTGTTCATGTCG
GAGATGATGAACTTCTCACTGATTTTGCTTTGTTAAGTATCGACATCCCTGAAAACCAAATTGATATTTTAGACATTGAT
ACATTACCTTCTGATTGGAATGCTCCCGTACCTTCTACTTGCACAATGGAAATAGGCAGTGAATGGTTCGAGGTTAGTCA
TTCTATTGGCCTGGTAGTTCCCTCTGCCATTGTCCCCTACGAAAATAACGTCATTTTGAATCCTATGGCGAAAGATTTTC
ATAAATATATAAACACGGTTAAACGCTTGGATTTTGGCATTGATTCCCGTTTAGTAAAGGCAAAAAAATAA
GTGATCTTATACCGACTTACCCGTTCAAAATATGTCGAATCAGCATGGAGTGGTACAGGAGCAAAGTTATATGGTGGCCG
TTGGCACAATATAGGAAGACCCGCAGTTTATGTAGCCACTTCAGTTTCTCTTGCTGTGCTAGAAGTACTTGTTCATGTCG
GAGATGATGAACTTCTCACTGATTTTGCTTTGTTAAGTATCGACATCCCTGAAAACCAAATTGATATTTTAGACATTGAT
ACATTACCTTCTGATTGGAATGCTCCCGTACCTTCTACTTGCACAATGGAAATAGGCAGTGAATGGTTCGAGGTTAGTCA
TTCTATTGGCCTGGTAGTTCCCTCTGCCATTGTCCCCTACGAAAATAACGTCATTTTGAATCCTATGGCGAAAGATTTTC
ATAAATATATAAACACGGTTAAACGCTTGGATTTTGGCATTGATTCCCGTTTAGTAAAGGCAAAAAAATAA
Antitoxin
Download Length: 149 a.a. Molecular weight: 16466.92 Da Isoelectric Point: 10.4604
>AT62848 WP_011146593.1 NZ_CP015281:2776301-2776747 [Photorhabdus laumondii subsp. laumondii]
MRVFTPSHKVQSNPLWRTVGFPSSSGPHLNAILNEGLPVTIVDKIQNWSTFGKGDILRIAGIQIRSYSRRCSGKGKFTAD
ESQRIARFVRVMDHAVDLFNGDKDKAAQWMKRPIRGLGYVTPESMLDTESGALDVMNLIGRIEHGIVS
MRVFTPSHKVQSNPLWRTVGFPSSSGPHLNAILNEGLPVTIVDKIQNWSTFGKGDILRIAGIQIRSYSRRCSGKGKFTAD
ESQRIARFVRVMDHAVDLFNGDKDKAAQWMKRPIRGLGYVTPESMLDTESGALDVMNLIGRIEHGIVS
Download Length: 447 bp
>AT62848 NZ_CP015281:2776301-2776747 [Photorhabdus laumondii subsp. laumondii]
ATGCGAGTTTTTACACCAAGCCACAAAGTCCAGAGTAACCCACTTTGGCGAACAGTTGGTTTCCCATCAAGCAGTGGGCC
ACATTTGAATGCAATATTAAATGAAGGGTTACCAGTCACTATAGTTGATAAAATACAAAACTGGTCAACGTTCGGTAAAG
GGGATATTTTGCGGATTGCAGGTATCCAAATACGCAGTTATTCAAGACGCTGTTCAGGTAAAGGTAAATTTACTGCTGAT
GAAAGTCAGCGCATTGCTCGGTTTGTACGTGTCATGGACCATGCTGTAGATTTATTTAATGGTGACAAAGATAAAGCAGC
TCAATGGATGAAGCGACCTATCCGGGGTTTAGGATACGTAACGCCTGAATCAATGCTCGATACAGAAAGTGGAGCGCTAG
ATGTCATGAATCTCATCGGCAGGATTGAACACGGAATTGTATCGTGA
ATGCGAGTTTTTACACCAAGCCACAAAGTCCAGAGTAACCCACTTTGGCGAACAGTTGGTTTCCCATCAAGCAGTGGGCC
ACATTTGAATGCAATATTAAATGAAGGGTTACCAGTCACTATAGTTGATAAAATACAAAACTGGTCAACGTTCGGTAAAG
GGGATATTTTGCGGATTGCAGGTATCCAAATACGCAGTTATTCAAGACGCTGTTCAGGTAAAGGTAAATTTACTGCTGAT
GAAAGTCAGCGCATTGCTCGGTTTGTACGTGTCATGGACCATGCTGTAGATTTATTTAATGGTGACAAAGATAAAGCAGC
TCAATGGATGAAGCGACCTATCCGGGGTTTAGGATACGTAACGCCTGAATCAATGCTCGATACAGAAAGTGGAGCGCTAG
ATGTCATGAATCTCATCGGCAGGATTGAACACGGAATTGTATCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6L9JJU4 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6L9JG75 |