Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 2706246..2706796 Replicon chromosome
Accession NZ_CP015281
Organism Photorhabdus laumondii subsp. laumondii strain DSPV002N

Toxin (Protein)


Gene name parE Uniprot ID Q7N4M0
Locus tag A4R40_RS11920 Protein ID WP_011146553.1
Coordinates 2706506..2706796 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q7N4M1
Locus tag A4R40_RS11915 Protein ID WP_011146552.1
Coordinates 2706246..2706518 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4R40_RS11890 2701462..2702943 - 1482 WP_011146548.1 type VI secretion system contractile sheath large subunit -
A4R40_RS11895 2702951..2703502 - 552 WP_109791569.1 type VI secretion system contractile sheath small subunit -
A4R40_RS11900 2704227..2704481 + 255 WP_011146550.1 hypothetical protein -
A4R40_RS11905 2704726..2705601 - 876 WP_011146551.1 phage tail protein -
A4R40_RS11915 2706246..2706518 + 273 WP_011146552.1 CopG family ribbon-helix-helix protein Antitoxin
A4R40_RS11920 2706506..2706796 + 291 WP_011146553.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A4R40_RS11930 2707021..2707197 + 177 Protein_2271 IS1595 family transposase -
A4R40_RS11935 2707234..2707512 - 279 WP_011146554.1 putative addiction module antidote protein -
A4R40_RS11940 2707509..2707811 - 303 WP_011146555.1 type II toxin-antitoxin system RelE/ParE family toxin -
A4R40_RS11945 2707909..2708049 + 141 WP_082302859.1 recombinase family protein -
A4R40_RS11950 2708042..2708230 - 189 Protein_2275 helix-turn-helix domain-containing protein -
A4R40_RS11955 2708220..2708309 - 90 Protein_2276 class A beta-lactamase -
A4R40_RS11960 2709004..2710857 + 1854 WP_011146556.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-94)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10867.56 Da        Isoelectric Point: 10.0918

>T62846 WP_011146553.1 NZ_CP015281:2706506-2706796 [Photorhabdus laumondii subsp. laumondii]
MPRLIWSPPALADIQRLYGFLAKKDKDTARRAIKTIRAGVKMLARQPEAGRPADDMDPAFREWLIDFGSSGYIALYRIEG
ETATIFAVRHQKEAGY

Download         Length: 291 bp

>T62846 NZ_CP015281:2706506-2706796 [Photorhabdus laumondii subsp. laumondii]
ATGCCACGTTTGATTTGGTCTCCGCCTGCTCTCGCTGATATACAGCGGCTCTATGGTTTTCTTGCTAAAAAAGACAAAGA
CACTGCTCGTCGAGCTATTAAAACAATACGTGCTGGCGTGAAAATGCTGGCACGTCAGCCTGAAGCAGGACGCCCTGCTG
ACGATATGGATCCGGCATTCCGAGAATGGCTTATTGATTTTGGAAGTAGTGGCTATATCGCCTTGTATCGGATTGAGGGT
GAAACAGCAACAATTTTTGCTGTACGGCATCAAAAAGAGGCCGGATATTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10654.87 Da        Isoelectric Point: 4.6704

>AT62846 WP_011146552.1 NZ_CP015281:2706246-2706518 [Photorhabdus laumondii subsp. laumondii]
MATSVKLDDNLKSRIQYLAEVRHRSAHWIMREAIRDYVEREEKRESFKQDALRAWEAYQENGLHLTLEEADDWLAKLEAG
EDAELPECHV

Download         Length: 273 bp

>AT62846 NZ_CP015281:2706246-2706518 [Photorhabdus laumondii subsp. laumondii]
ATGGCAACCTCAGTAAAACTTGACGATAACTTGAAAAGCCGGATCCAGTATTTGGCAGAAGTGCGACATCGTTCAGCTCA
TTGGATAATGCGTGAAGCTATACGTGACTATGTAGAGCGCGAGGAAAAGCGTGAATCTTTCAAACAGGATGCATTGCGTG
CTTGGGAAGCGTATCAAGAGAATGGACTACACCTGACGCTTGAAGAAGCGGACGACTGGTTAGCTAAGCTCGAAGCAGGA
GAAGATGCGGAGTTACCTGAATGCCACGTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6L9JTC2

Antitoxin

Source ID Structure
AlphaFold DB A0A6L9JNK5

References