Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE(toxin)
Location 2489208..2489739 Replicon chromosome
Accession NZ_CP015281
Organism Photorhabdus laumondii subsp. laumondii strain DSPV002N

Toxin (Protein)


Gene name relE Uniprot ID Q7N553
Locus tag A4R40_RS10905 Protein ID WP_011146359.1
Coordinates 2489449..2489739 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q7N554
Locus tag A4R40_RS10900 Protein ID WP_011146358.1
Coordinates 2489208..2489459 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4R40_RS10865 2484707..2485270 + 564 WP_109791520.1 VOC family protein -
A4R40_RS10870 2485286..2485600 - 315 WP_011146353.1 type II toxin-antitoxin system MqsA family antitoxin -
A4R40_RS10875 2485601..2485936 - 336 WP_011146354.1 hypothetical protein -
A4R40_RS10880 2485991..2486149 + 159 Protein_2062 VOC family protein -
A4R40_RS10885 2486287..2487033 + 747 WP_011146355.1 copper homeostasis protein CutC -
A4R40_RS10890 2487209..2488180 - 972 WP_011146356.1 tRNA 5-methoxyuridine(34)/uridine 5-oxyacetic acid(34) synthase CmoB -
A4R40_RS10895 2488177..2488935 - 759 WP_011146357.1 carboxy-S-adenosyl-L-methionine synthase CmoA -
A4R40_RS10900 2489208..2489459 + 252 WP_011146358.1 plasmid stabilization protein Antitoxin
A4R40_RS10905 2489449..2489739 + 291 WP_011146359.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A4R40_RS10910 2489866..2490261 - 396 WP_011146360.1 MAPEG family protein -
A4R40_RS10915 2490538..2492310 + 1773 WP_011146361.1 aspartate--tRNA ligase -
A4R40_RS10920 2492310..2492747 + 438 WP_011146362.1 dihydroneopterin triphosphate diphosphatase -
A4R40_RS10925 2492777..2493520 + 744 WP_011146363.1 YebC/PmpR family DNA-binding transcriptional regulator -
A4R40_RS10930 2493752..2494273 + 522 WP_011146364.1 crossover junction endodeoxyribonuclease RuvC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11169.14 Da        Isoelectric Point: 11.2253

>T62842 WP_011146359.1 NZ_CP015281:2489449-2489739 [Photorhabdus laumondii subsp. laumondii]
MIYSLQFEKRALKEWKKLGHPIKEQLKRKLAERLENPHVPSARLSGRSNRYKIKLRSSGNRLVYEVNDNKIILLVIAIGK
RGKRVGDAVYTLANER

Download         Length: 291 bp

>T62842 NZ_CP015281:2489449-2489739 [Photorhabdus laumondii subsp. laumondii]
ATGATCTATAGTCTGCAATTTGAAAAGCGGGCCTTAAAAGAGTGGAAGAAGTTAGGTCATCCAATTAAGGAGCAGCTAAA
GAGAAAATTGGCTGAACGCTTAGAAAACCCTCATGTGCCGTCAGCAAGATTAAGTGGGCGATCGAACCGATACAAAATTA
AATTGCGGTCTTCTGGCAACCGCTTGGTTTATGAAGTGAATGACAATAAGATTATCTTGCTGGTAATTGCTATTGGTAAA
CGTGGTAAACGGGTCGGAGATGCGGTTTATACCCTCGCCAATGAGAGGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9270.42 Da        Isoelectric Point: 3.8209

>AT62842 WP_011146358.1 NZ_CP015281:2489208-2489459 [Photorhabdus laumondii subsp. laumondii]
MAYQILTNLAASITDLKRNPMGTYLQGEGEAVAILNRNEPAFYCVPPELFAYYQELAEDAALNKIADERLENAEFVSVNL
DDL

Download         Length: 252 bp

>AT62842 NZ_CP015281:2489208-2489459 [Photorhabdus laumondii subsp. laumondii]
ATGGCATATCAAATCTTAACAAATTTAGCGGCAAGTATTACCGATTTGAAACGTAACCCAATGGGGACATATTTGCAGGG
GGAAGGTGAAGCGGTCGCAATCCTGAATCGGAATGAACCTGCATTTTATTGTGTGCCTCCTGAATTATTCGCCTACTATC
AGGAGCTAGCAGAGGATGCCGCACTAAACAAAATTGCAGATGAACGTTTAGAAAATGCTGAATTTGTTAGTGTGAACCTG
GATGATCTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6L9JHY5

Antitoxin

Source ID Structure
AlphaFold DB A0A6L9JPX9

References