Detailed information of TA system TA062842

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE(toxin)
• Location: 2489208..2489739
• Replicon: chromosome
• Accession: NZ_CP015281
• Organism: Photorhabdus laumondii subsp. laumondii strain DSPV002N

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q7N553
• Locus tag: A4R40_RS10905
• Protein ID: WP_011146359.1
• Coordinates: 2489449..2489739 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q7N554
• Locus tag: A4R40_RS10900
• Protein ID: WP_011146358.1
• Coordinates: 2489208..2489459 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A4R40_RS10865	2484707..2485270	+	564	WP_109791520.1	VOC family protein	-
A4R40_RS10870	2485286..2485600	-	315	WP_011146353.1	type II toxin-antitoxin system MqsA family antitoxin	-
A4R40_RS10875	2485601..2485936	-	336	WP_011146354.1	hypothetical protein	-
A4R40_RS10880	2485991..2486149	+	159	Protein_2062	VOC family protein	-
A4R40_RS10885	2486287..2487033	+	747	WP_011146355.1	copper homeostasis protein CutC	-
A4R40_RS10890	2487209..2488180	-	972	WP_011146356.1	tRNA 5-methoxyuridine(34)/uridine 5-oxyacetic acid(34) synthase CmoB	-
A4R40_RS10895	2488177..2488935	-	759	WP_011146357.1	carboxy-S-adenosyl-L-methionine synthase CmoA	-
A4R40_RS10900	2489208..2489459	+	252	WP_011146358.1	plasmid stabilization protein	Antitoxin
A4R40_RS10905	2489449..2489739	+	291	WP_011146359.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
A4R40_RS10910	2489866..2490261	-	396	WP_011146360.1	MAPEG family protein	-
A4R40_RS10915	2490538..2492310	+	1773	WP_011146361.1	aspartate--tRNA ligase	-
A4R40_RS10920	2492310..2492747	+	438	WP_011146362.1	dihydroneopterin triphosphate diphosphatase	-
A4R40_RS10925	2492777..2493520	+	744	WP_011146363.1	YebC/PmpR family DNA-binding transcriptional regulator	-
A4R40_RS10930	2493752..2494273	+	522	WP_011146364.1	crossover junction endodeoxyribonuclease RuvC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11169.14 Da
• Isoelectric Point: 11.2253

>T62842 WP_011146359.1 NZ_CP015281:2489449-2489739 [Photorhabdus laumondii subsp. laumondii]
MIYSLQFEKRALKEWKKLGHPIKEQLKRKLAERLENPHVPSARLSGRSNRYKIKLRSSGNRLVYEVNDNKIILLVIAIGK
RGKRVGDAVYTLANER

Nucleotide

• Length: 291 bp

>T62842 NZ_CP015281:2489449-2489739 [Photorhabdus laumondii subsp. laumondii]
ATGATCTATAGTCTGCAATTTGAAAAGCGGGCCTTAAAAGAGTGGAAGAAGTTAGGTCATCCAATTAAGGAGCAGCTAAA
GAGAAAATTGGCTGAACGCTTAGAAAACCCTCATGTGCCGTCAGCAAGATTAAGTGGGCGATCGAACCGATACAAAATTA
AATTGCGGTCTTCTGGCAACCGCTTGGTTTATGAAGTGAATGACAATAAGATTATCTTGCTGGTAATTGCTATTGGTAAA
CGTGGTAAACGGGTCGGAGATGCGGTTTATACCCTCGCCAATGAGAGGTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9270.42 Da
• Isoelectric Point: 3.8209

>AT62842 WP_011146358.1 NZ_CP015281:2489208-2489459 [Photorhabdus laumondii subsp. laumondii]
MAYQILTNLAASITDLKRNPMGTYLQGEGEAVAILNRNEPAFYCVPPELFAYYQELAEDAALNKIADERLENAEFVSVNL
DDL

Nucleotide

• Length: 252 bp

>AT62842 NZ_CP015281:2489208-2489459 [Photorhabdus laumondii subsp. laumondii]
ATGGCATATCAAATCTTAACAAATTTAGCGGCAAGTATTACCGATTTGAAACGTAACCCAATGGGGACATATTTGCAGGG
GGAAGGTGAAGCGGTCGCAATCCTGAATCGGAATGAACCTGCATTTTATTGTGTGCCTCCTGAATTATTCGCCTACTATC
AGGAGCTAGCAGAGGATGCCGCACTAAACAAAATTGCAGATGAACGTTTAGAAAATGCTGAATTTGTTAGTGTGAACCTG
GATGATCTATAG

Structures

Toxin

• AlphaFold DB: A0A6L9JHY5

Antitoxin

• AlphaFold DB: A0A6L9JPX9