Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 816018..816646 Replicon chromosome
Accession NZ_CP015281
Organism Photorhabdus laumondii subsp. laumondii strain DSPV002N

Toxin (Protein)


Gene name hicA Uniprot ID Q7N8L3
Locus tag A4R40_RS03655 Protein ID WP_011145083.1
Coordinates 816371..816646 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q7N8L4
Locus tag A4R40_RS03650 Protein ID WP_011145082.1
Coordinates 816018..816374 (-) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4R40_RS03630 811020..811382 - 363 WP_011145078.1 6-carboxytetrahydropterin synthase QueD -
A4R40_RS03635 811649..813451 + 1803 WP_011145079.1 NADPH-dependent assimilatory sulfite reductase flavoprotein subunit -
A4R40_RS03640 813451..815181 + 1731 WP_011145080.1 assimilatory sulfite reductase (NADPH) hemoprotein subunit -
A4R40_RS03645 815178..815912 + 735 WP_011145081.1 phosphoadenylyl-sulfate reductase -
A4R40_RS03650 816018..816374 - 357 WP_011145082.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
A4R40_RS03655 816371..816646 - 276 WP_011145083.1 type II toxin-antitoxin system HicA family toxin Toxin
A4R40_RS03660 816914..818326 + 1413 WP_011145084.1 siroheme synthase CysG -
A4R40_RS03665 818336..819244 + 909 WP_011145085.1 sulfate adenylyltransferase subunit CysD -
A4R40_RS03670 819256..820698 + 1443 WP_058589762.1 sulfate adenylyltransferase subunit CysN -
A4R40_RS03675 820700..821332 + 633 WP_011145087.1 adenylyl-sulfate kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-85)

Antitoxin

Uncharacterised protein family HicB

(59-111)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10236.91 Da        Isoelectric Point: 9.9633

>T62835 WP_011145083.1 NZ_CP015281:c816646-816371 [Photorhabdus laumondii subsp. laumondii]
MKEQVSMLRKRQKNTLEQIFKMPVPAGIKWSDVESLIIALGGEVKEGKGSRCRLLLNDSIARFHRPHPSPDTDKGAVVSL
REWLESIGVEP

Download         Length: 276 bp

>T62835 NZ_CP015281:c816646-816371 [Photorhabdus laumondii subsp. laumondii]
ATGAAAGAACAGGTTTCAATGCTCAGGAAGAGGCAAAAAAATACGTTGGAGCAGATATTTAAAATGCCTGTTCCTGCGGG
AATTAAGTGGTCTGACGTGGAATCACTCATAATCGCTCTGGGAGGTGAGGTTAAAGAGGGGAAAGGTTCACGTTGCAGGC
TGTTGCTAAACGATAGTATTGCCAGATTTCACCGTCCACATCCCTCACCAGATACTGACAAAGGGGCCGTCGTCAGCCTA
CGAGAATGGTTAGAAAGCATAGGAGTTGAGCCATGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 13321.23 Da        Isoelectric Point: 5.5798

>AT62835 WP_011145082.1 NZ_CP015281:c816374-816018 [Photorhabdus laumondii subsp. laumondii]
MKMTVQNTMVIAGQQAIISYVPEIGMFRGKFLGLSGYCDFISDSIQGLQDEGKISLHEYLEDCNASGIEPYARQEKIKTF
TLRYPESFGERLHCAAAEHQISVNAFIIETLNERMKHA

Download         Length: 357 bp

>AT62835 NZ_CP015281:c816374-816018 [Photorhabdus laumondii subsp. laumondii]
ATGAAGATGACAGTACAAAATACAATGGTAATAGCCGGACAGCAGGCTATTATTAGCTACGTGCCAGAAATTGGCATGTT
CAGGGGTAAATTTTTAGGGCTGTCTGGTTATTGTGATTTTATCTCTGATAGTATTCAGGGGTTGCAAGATGAGGGTAAAA
TATCTCTACATGAATATCTTGAAGATTGTAACGCATCAGGTATTGAACCTTATGCAAGGCAAGAAAAAATCAAAACATTT
ACTCTGCGCTACCCCGAATCATTTGGAGAGCGATTGCATTGCGCAGCAGCCGAGCATCAGATTTCGGTGAATGCGTTCAT
CATTGAAACTTTAAATGAACGAATGAAACACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6L9JQS1

Antitoxin

Source ID Structure
AlphaFold DB A0A6L9JRP4

References