Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 271540..272074 Replicon chromosome
Accession NZ_CP015281
Organism Photorhabdus laumondii subsp. laumondii strain DSPV002N

Toxin (Protein)


Gene name relE Uniprot ID Q7N9Q9
Locus tag A4R40_RS01310 Protein ID WP_011144654.1
Coordinates 271784..272074 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q7N9R0
Locus tag A4R40_RS01305 Protein ID WP_011144653.1
Coordinates 271540..271794 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4R40_RS01280 266884..267075 + 192 Protein_244 hypothetical protein -
A4R40_RS01285 267752..268495 + 744 WP_011144649.1 class I SAM-dependent methyltransferase -
A4R40_RS01290 268771..269178 - 408 WP_011144650.1 type II toxin-antitoxin system RelE/ParE family toxin -
A4R40_RS01295 269181..269450 - 270 WP_011144651.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
A4R40_RS01300 270366..271133 + 768 WP_011144652.1 Fic family protein -
A4R40_RS01305 271540..271794 + 255 WP_011144653.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
A4R40_RS01310 271784..272074 + 291 WP_011144654.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A4R40_RS01320 273063..273323 - 261 WP_011144656.1 hypothetical protein -
A4R40_RS01325 273417..273695 - 279 WP_011144657.1 hypothetical protein -
A4R40_RS01330 274351..276432 - 2082 WP_109791260.1 ATP-dependent DNA helicase RecG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-47)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11349.32 Da        Isoelectric Point: 9.9557

>T62834 WP_011144654.1 NZ_CP015281:271784-272074 [Photorhabdus laumondii subsp. laumondii]
MIFNIDFDERALKEWYKLDQSIRDQFKKKLRKLQNNPYIDSARLHGNLAGCFKIKLRSSGFRLVYQVIEEEIVILVIAVG
KREDAKTYEIACKRIV

Download         Length: 291 bp

>T62834 NZ_CP015281:271784-272074 [Photorhabdus laumondii subsp. laumondii]
ATGATATTTAATATCGATTTCGACGAACGAGCCCTGAAAGAGTGGTACAAACTGGATCAGAGCATACGCGACCAATTTAA
AAAGAAGCTACGGAAGTTACAGAACAATCCCTATATTGATTCAGCCAGATTACACGGTAATCTGGCTGGCTGCTTTAAAA
TTAAACTCCGTTCTTCAGGCTTTCGTCTGGTTTACCAAGTGATAGAAGAAGAGATCGTAATATTGGTGATCGCTGTTGGT
AAACGGGAAGATGCGAAAACTTATGAAATAGCTTGTAAACGAATTGTATAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9774.19 Da        Isoelectric Point: 4.8485

>AT62834 WP_011144653.1 NZ_CP015281:271540-271794 [Photorhabdus laumondii subsp. laumondii]
MSTIQIRVDEELKKSAYQTFEKLNLSPSDALRLFLRYVVENEKLPFTEVSVMVADHDEDADILAVVRDRLKNPARRIRVN
LDDI

Download         Length: 255 bp

>AT62834 NZ_CP015281:271540-271794 [Photorhabdus laumondii subsp. laumondii]
ATGAGTACTATTCAGATCAGAGTTGATGAAGAACTTAAAAAAAGTGCGTATCAGACATTTGAGAAACTGAACTTATCGCC
ATCTGATGCGCTACGTCTCTTTCTGCGATATGTTGTGGAGAATGAAAAGCTGCCGTTCACTGAAGTTTCCGTTATGGTGG
CAGATCATGATGAAGATGCAGACATCTTAGCAGTGGTACGTGACCGTCTTAAAAATCCCGCTAGACGTATCAGGGTAAAC
CTTGATGATATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6L9JHV9

Antitoxin

Source ID Structure
AlphaFold DB A0A6L9JHC8

References