62831

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-YefM
Location 94057..94595 Replicon plasmid unnamed 2
Accession NZ_CP015280
Organism Mycobacterium intracellulare subsp. chimaera strain DSM 44623

Toxin (Protein)


Gene name relE Uniprot ID D5P5D7
Locus tag MYCODSM44623_RS28755 Protein ID WP_007172405.1
Coordinates 94057..94314 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID M1FTM7
Locus tag MYCODSM44623_RS28760 Protein ID WP_007172404.1
Coordinates 94311..94595 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MYCODSM44623_RS28735 89130..91088 - 1959 WP_033719466.1 DDE-type integrase/transposase/recombinase -
MYCODSM44623_RS28740 91211..91951 - 741 WP_099459185.1 TnsA-like heteromeric transposase endonuclease subunit -
MYCODSM44623_RS28745 92534..93532 + 999 WP_101930848.1 hypothetical protein -
MYCODSM44623_RS28750 93549..93842 + 294 WP_007172406.1 hypothetical protein -
MYCODSM44623_RS28755 94057..94314 - 258 WP_007172405.1 Txe/YoeB family addiction module toxin Toxin
MYCODSM44623_RS28760 94311..94595 - 285 WP_007172404.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MYCODSM44623_RS29395 94677..95438 - 762 WP_023363524.1 hypothetical protein -
MYCODSM44623_RS28770 95441..96163 - 723 WP_139315444.1 ParA family protein -
MYCODSM44623_RS28775 96827..97720 + 894 WP_052742716.1 DUF2637 domain-containing protein -
MYCODSM44623_RS28780 97942..99462 + 1521 WP_007172379.1 DUF4226 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - esxN / eccA5 1..110830 110830


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-70)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10156.56 Da        Isoelectric Point: 9.8613

>T62831 WP_007172405.1 NZ_CP015280:c94314-94057 [Mycobacterium intracellulare subsp. chimaera]
VRSINFDPAAWEDFLFWLASDRKTARRITRLIAEIQRNPFAGIGKPEPLKGELSGYWSRRIDDEHRIVYRADDHEIKILK
ARYHY

Download         Length: 258 bp

>T62831 NZ_CP015280:c94314-94057 [Mycobacterium intracellulare subsp. chimaera]
GTGAGAAGCATCAACTTCGATCCCGCCGCGTGGGAGGACTTTCTATTTTGGCTGGCTTCCGACCGCAAAACAGCACGGCG
CATCACCAGACTCATCGCAGAAATCCAGCGCAACCCGTTTGCTGGGATTGGAAAACCAGAACCGCTCAAGGGTGAACTAT
CCGGGTACTGGTCGCGGCGCATCGACGACGAACACCGGATCGTCTACCGCGCAGATGATCACGAAATCAAGATCCTCAAA
GCCCGATACCACTACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10455.62 Da        Isoelectric Point: 4.3885

>AT62831 WP_007172404.1 NZ_CP015280:c94595-94311 [Mycobacterium intracellulare subsp. chimaera]
MAISASEARQRLFPLLEQVNTDHEPVRITSKAGDAVLMSAADYDSWQETVYLLRSPENARRLMEAVARDNATRPTPGSYT
KSIDELEEMAGGQE

Download         Length: 285 bp

>AT62831 NZ_CP015280:c94595-94311 [Mycobacterium intracellulare subsp. chimaera]
ATGGCTATCAGTGCAAGTGAGGCCCGGCAGCGCCTCTTTCCGCTGCTTGAACAAGTCAACACCGACCACGAGCCTGTGCG
AATTACGTCCAAGGCCGGAGATGCAGTGCTCATGTCGGCCGCTGACTACGATTCGTGGCAAGAAACGGTCTACCTCCTGC
GTTCCCCCGAGAATGCCCGCCGACTCATGGAGGCCGTCGCCCGAGACAACGCCACCCGGCCCACCCCCGGCAGCTACACC
AAGTCGATCGACGAACTCGAGGAGATGGCCGGCGGCCAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Y0THX2

Antitoxin

Source ID Structure
AlphaFold DB M1FTM7

References