62830

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 13917..14599 Replicon plasmid unnamed 2
Accession NZ_CP015280
Organism Mycobacterium intracellulare subsp. chimaera strain DSM 44623

Toxin (Protein)


Gene name vapC Uniprot ID A0A854IDQ2
Locus tag MYCODSM44623_RS28360 Protein ID WP_040624374.1
Coordinates 13917..14333 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID D5P579
Locus tag MYCODSM44623_RS28365 Protein ID WP_007172349.1
Coordinates 14336..14599 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MYCODSM44623_RS28335 9127..9900 + 774 Protein_10 IS256 family transposase -
MYCODSM44623_RS28340 9999..11051 + 1053 WP_046183199.1 tyrosine-type recombinase/integrase -
MYCODSM44623_RS28345 11054..11371 + 318 WP_046183198.1 helix-turn-helix transcriptional regulator -
MYCODSM44623_RS28350 11374..12984 + 1611 WP_046183197.1 hypothetical protein -
MYCODSM44623_RS28355 13033..13635 + 603 Protein_14 IS256 family transposase -
MYCODSM44623_RS28360 13917..14333 - 417 WP_040624374.1 type II toxin-antitoxin system VapC family toxin Toxin
MYCODSM44623_RS28365 14336..14599 - 264 WP_007172349.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MYCODSM44623_RS28370 14701..15675 + 975 WP_023363505.1 hypothetical protein -
MYCODSM44623_RS28375 15739..16842 + 1104 WP_051404593.1 hypothetical protein -
MYCODSM44623_RS28380 16928..17968 + 1041 WP_023363502.1 C40 family peptidase -
MYCODSM44623_RS28385 18082..19527 + 1446 WP_101930849.1 type VII secretion protein EccB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - esxN / eccA5 1..110830 110830


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(1-82)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14879.84 Da        Isoelectric Point: 5.4519

>T62830 WP_040624374.1 NZ_CP015280:c14333-13917 [Mycobacterium intracellulare subsp. chimaera]
MIIDSSAIVALIQGEDPYTEQIAAAIAADPSPVMSTANAAECLIVLTNRHGATARTVFDRLRSEINLGFQPFTLEHAIAA
HRAYLHYGKGRHPAALNYGDTMAYATAKLAHEPLIAIGNDFTQTDLEFNGVIGYWPAP

Download         Length: 417 bp

>T62830 NZ_CP015280:c14333-13917 [Mycobacterium intracellulare subsp. chimaera]
CTGATCATCGACTCTTCCGCGATCGTCGCCCTCATCCAGGGCGAGGACCCCTACACCGAACAGATCGCGGCCGCCATCGC
CGCCGATCCCAGCCCCGTCATGTCCACGGCCAACGCAGCCGAATGCCTCATCGTTCTCACCAACCGACACGGCGCGACCG
CGCGCACCGTCTTCGACCGCCTACGATCCGAAATCAACCTCGGCTTCCAGCCCTTCACCCTCGAACACGCGATCGCCGCC
CACCGCGCCTACCTCCACTACGGAAAAGGCCGCCACCCCGCCGCCCTCAACTACGGCGACACCATGGCCTACGCCACCGC
CAAACTCGCACACGAACCCCTCATCGCCATCGGCAACGACTTCACCCAAACCGACCTCGAATTCAACGGCGTCATCGGCT
ACTGGCCAGCGCCCTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9884.20 Da        Isoelectric Point: 4.8359

>AT62830 WP_007172349.1 NZ_CP015280:c14599-14336 [Mycobacterium intracellulare subsp. chimaera]
MAFNVKDEEVIRFADELAARLHLPSRIDAIRYALRAQIEVTQSRTANRSAELLDVLKTEIWPLLDDRSPITKTEREQALG
YDTATGV

Download         Length: 264 bp

>AT62830 NZ_CP015280:c14599-14336 [Mycobacterium intracellulare subsp. chimaera]
ATGGCTTTCAACGTGAAAGACGAAGAGGTCATCCGCTTCGCAGACGAGCTCGCCGCGCGCCTCCACCTCCCCAGCCGCAT
CGACGCCATCCGCTACGCCCTGCGAGCCCAGATCGAAGTCACCCAATCCCGCACCGCAAACCGCTCCGCAGAACTGCTCG
ACGTCCTCAAAACCGAGATCTGGCCACTACTGGACGACCGATCCCCAATCACCAAAACCGAACGCGAACAAGCCCTCGGA
TACGACACAGCAACGGGAGTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A854IDQ2

Antitoxin

Source ID Structure
AlphaFold DB A0A1Y0TBQ2

References