62829

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 151917..152464 Replicon plasmid unnamed 1
Accession NZ_CP015279
Organism Mycobacterium intracellulare subsp. chimaera strain DSM 44623

Toxin (Protein)


Gene name relE Uniprot ID A0A7U5MRA3
Locus tag MYCODSM44623_RS28275 Protein ID WP_052955269.1
Coordinates 151917..152198 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1X0K5A9
Locus tag MYCODSM44623_RS28280 Protein ID WP_047322047.1
Coordinates 152195..152464 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MYCODSM44623_RS28250 148143..148439 + 297 WP_033718771.1 DUF1490 family protein -
MYCODSM44623_RS28255 148495..150864 + 2370 WP_089150873.1 copper-translocating P-type ATPase -
MYCODSM44623_RS28260 150852..151214 + 363 WP_129560167.1 transposase -
MYCODSM44623_RS28265 151358..151621 + 264 WP_007172605.1 hypothetical protein -
MYCODSM44623_RS28270 151618..151782 - 165 Protein_148 hypothetical protein -
MYCODSM44623_RS28275 151917..152198 - 282 WP_052955269.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MYCODSM44623_RS28280 152195..152464 - 270 WP_047322047.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MYCODSM44623_RS28285 152580..153245 - 666 WP_047322046.1 RES family NAD+ phosphorylase -
MYCODSM44623_RS28290 153242..153829 - 588 WP_047322045.1 hypothetical protein -
MYCODSM44623_RS28295 154603..154836 - 234 WP_192579511.1 hypothetical protein -
MYCODSM44623_RS28300 154844..155769 - 926 Protein_154 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - esxN / eccA5 1..157126 157126


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-90)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10672.31 Da        Isoelectric Point: 10.2981

>T62829 WP_052955269.1 NZ_CP015279:c152198-151917 [Mycobacterium intracellulare subsp. chimaera]
VSCEEASWSVHFSPTAIRALDRLPLKVAKAIAEFITGTLPTDPNRLSKPLSFEFAGWRVARRGDYRVAFRILEDDRVLLI
GRIEHRAHIYRQP

Download         Length: 282 bp

>T62829 NZ_CP015279:c152198-151917 [Mycobacterium intracellulare subsp. chimaera]
GTGAGCTGCGAAGAAGCGTCCTGGTCCGTTCACTTCTCGCCTACCGCGATCCGGGCACTCGACCGTCTACCGCTGAAAGT
CGCCAAAGCGATCGCCGAATTCATCACAGGCACACTGCCCACCGACCCGAACCGGCTATCCAAACCGTTGAGCTTCGAAT
TCGCTGGCTGGCGCGTCGCCCGGCGCGGCGATTACCGCGTCGCATTCCGGATTCTCGAAGACGACCGGGTCCTGTTGATC
GGTCGCATCGAGCACCGCGCACACATCTACCGCCAACCATGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9692.77 Da        Isoelectric Point: 4.6389

>AT62829 WP_047322047.1 NZ_CP015279:c152464-152195 [Mycobacterium intracellulare subsp. chimaera]
MKNVPLSEAKDKLSALVDEADTTHEIIQITRHGRAAAVLMSADDLDSLNETLHALRTPGFAEDLAQADADYAAGNTVTGE
EIRRRYGLR

Download         Length: 270 bp

>AT62829 NZ_CP015279:c152464-152195 [Mycobacterium intracellulare subsp. chimaera]
ATGAAGAACGTACCGCTCTCGGAGGCCAAGGACAAGCTCTCCGCGCTCGTCGACGAGGCCGACACCACCCACGAAATCAT
TCAGATCACCCGACACGGGCGCGCCGCCGCGGTCCTGATGTCTGCCGACGATCTGGATTCACTCAACGAGACGCTGCACG
CACTGCGAACACCCGGTTTTGCCGAAGACCTCGCGCAGGCCGATGCCGACTACGCTGCCGGCAATACCGTCACTGGCGAG
GAGATCCGCCGGCGATACGGACTCAGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U5MRA3

Antitoxin

Source ID Structure
AlphaFold DB A0A1X0K5A9

References