62828

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 46822..47507 Replicon plasmid unnamed 1
Accession NZ_CP015279
Organism Mycobacterium intracellulare subsp. chimaera strain DSM 44623

Toxin (Protein)


Gene name vapC Uniprot ID A0A1X0JS24
Locus tag MYCODSM44623_RS27780 Protein ID WP_047324166.1
Coordinates 46822..47238 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1X0JR97
Locus tag MYCODSM44623_RS27785 Protein ID WP_047324157.1
Coordinates 47244..47507 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MYCODSM44623_RS27765 42106..42795 + 690 WP_047324298.1 hypothetical protein -
MYCODSM44623_RS29660 42801..42944 + 144 WP_167384289.1 hypothetical protein -
MYCODSM44623_RS29665 43030..43302 + 273 WP_142274731.1 hypothetical protein -
MYCODSM44623_RS29345 43972..46302 + 2331 WP_139315450.1 hypothetical protein -
MYCODSM44623_RS27780 46822..47238 - 417 WP_047324166.1 type II toxin-antitoxin system VapC family toxin Toxin
MYCODSM44623_RS27785 47244..47507 - 264 WP_047324157.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MYCODSM44623_RS27790 47755..48588 + 834 WP_074021485.1 hypothetical protein -
MYCODSM44623_RS27795 49191..49808 + 618 WP_085081455.1 transglycosylase SLT domain-containing protein -
MYCODSM44623_RS27800 50017..50922 + 906 WP_139315451.1 C40 family peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - esxN / eccA5 1..157126 157126


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15046.00 Da        Isoelectric Point: 5.0924

>T62828 WP_047324166.1 NZ_CP015279:c47238-46822 [Mycobacterium intracellulare subsp. chimaera]
VIIDSSALIALIQGEAPYTEQIAAALAGDRSPVMSTANAAECLIVLTSRHGATARTVFDRLRSEINLEFQPFTLEHAWIA
HRAYLQYGKGRHPAALNYGDTMAYATAKLAQEPLIAIGNDFAQTDLEFDGVIGYWPTH

Download         Length: 417 bp

>T62828 NZ_CP015279:c47238-46822 [Mycobacterium intracellulare subsp. chimaera]
GTGATCATCGACTCGTCAGCCCTTATTGCCTTGATCCAAGGCGAAGCCCCCTACACCGAACAGATCGCGGCCGCCCTCGC
CGGCGACCGTAGCCCGGTCATGTCCACGGCGAACGCCGCCGAATGCCTCATCGTGCTCACCAGCCGCCACGGCGCCACAG
CCCGCACCGTCTTCGACCGCCTCCGGTCCGAAATCAACCTCGAATTCCAACCATTCACACTCGAGCACGCGTGGATCGCA
CATCGGGCCTACCTCCAGTACGGAAAGGGTCGCCACCCCGCCGCCCTCAACTACGGAGACACCATGGCATACGCCACCGC
CAAACTCGCGCAGGAACCACTCATTGCGATCGGCAATGACTTCGCCCAAACAGACCTTGAATTCGACGGCGTCATCGGCT
ACTGGCCGACACACTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9933.19 Da        Isoelectric Point: 4.8308

>AT62828 WP_047324157.1 NZ_CP015279:c47507-47244 [Mycobacterium intracellulare subsp. chimaera]
MAFNVKDEEVIQFADELAARLHLPSRIDAIRYALRAQIEITQSRTGNRADELLDVLRTEIWPLLHDRSPISKTEREQALG
YNDATGV

Download         Length: 264 bp

>AT62828 NZ_CP015279:c47507-47244 [Mycobacterium intracellulare subsp. chimaera]
ATGGCTTTCAATGTGAAAGACGAAGAGGTGATCCAATTCGCCGACGAGCTCGCCGCCCGCCTGCACCTCCCCAGCCGCAT
CGACGCAATCCGCTACGCACTGCGCGCCCAGATCGAGATCACCCAATCCCGCACGGGAAACCGCGCCGACGAACTGCTCG
ACGTCCTCAGAACCGAGATCTGGCCACTGCTGCACGACCGATCCCCTATCAGCAAGACCGAACGCGAACAAGCGCTCGGA
TACAACGACGCCACGGGCGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X0JS24

Antitoxin

Source ID Structure
AlphaFold DB A0A1X0JR97

References