62823

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1511113..1511675 Replicon chromosome
Accession NZ_CP015278
Organism Mycobacterium intracellulare subsp. chimaera strain DSM 44623

Toxin (Protein)


Gene name vapC Uniprot ID A0A081I0A5
Locus tag MYCODSM44623_RS07455 Protein ID WP_036454801.1
Coordinates 1511307..1511675 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A081I0A4
Locus tag MYCODSM44623_RS07450 Protein ID WP_036455532.1
Coordinates 1511113..1511310 (+) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MYCODSM44623_RS07415 1506217..1507362 - 1146 WP_179945068.1 hypothetical protein -
MYCODSM44623_RS07420 1507492..1508565 + 1074 WP_042910932.1 redox-regulated ATPase YchF -
MYCODSM44623_RS07425 1508582..1509322 + 741 WP_042910933.1 aminoglycoside 3'-phosphotransferase -
MYCODSM44623_RS07430 1509410..1509694 + 285 WP_020821851.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
MYCODSM44623_RS07435 1509709..1509954 + 246 WP_042910934.1 type II toxin-antitoxin system RelE/ParE family toxin -
MYCODSM44623_RS07440 1509990..1510541 + 552 WP_036454798.1 VOC family protein -
MYCODSM44623_RS07445 1510620..1511018 + 399 WP_036454800.1 VOC family protein -
MYCODSM44623_RS07450 1511113..1511310 + 198 WP_036455532.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MYCODSM44623_RS07455 1511307..1511675 + 369 WP_036454801.1 type II toxin-antitoxin system VapC family toxin Toxin
MYCODSM44623_RS07460 1511858..1512199 + 342 WP_172417493.1 hypothetical protein -
MYCODSM44623_RS29755 1512285..1512644 + 360 WP_042910935.1 hypothetical protein -
MYCODSM44623_RS07470 1512829..1513404 + 576 WP_075630262.1 C40 family peptidase -
MYCODSM44623_RS07475 1513767..1514090 + 324 WP_036454806.1 antibiotic biosynthesis monooxygenase -
MYCODSM44623_RS07480 1514128..1514961 - 834 WP_036454808.1 SAM-dependent methyltransferase -
MYCODSM44623_RS07485 1514996..1515679 - 684 WP_036455537.1 hypothetical protein -
MYCODSM44623_RS07490 1515826..1516035 + 210 WP_072501223.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-111)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13435.74 Da        Isoelectric Point: 6.4862

>T62823 WP_036454801.1 NZ_CP015278:1511307-1511675 [Mycobacterium intracellulare subsp. chimaera]
MILVDTAVWIDHLHTAELRLVKLLEIDQVGCHALVIEELALGSISRREVVLDLLANLRQFPTVQHAEILHLTGQRKLYGR
GLSAVDVHLMAAVALVEGAQLWTRDKRLKAASVDAGIALFDA

Download         Length: 369 bp

>T62823 NZ_CP015278:1511307-1511675 [Mycobacterium intracellulare subsp. chimaera]
ATGATCCTCGTCGACACCGCGGTGTGGATCGATCATCTACACACCGCGGAGTTGCGGCTAGTCAAGCTGCTGGAGATCGA
CCAAGTTGGCTGTCATGCGCTGGTCATCGAAGAGCTGGCGCTGGGGTCGATCTCGCGACGTGAGGTGGTGCTCGACCTCC
TCGCGAATCTTCGCCAGTTTCCGACCGTCCAGCACGCCGAGATCCTTCACCTCACCGGTCAACGCAAACTGTATGGACGC
GGTCTCAGTGCGGTCGACGTCCATCTCATGGCCGCCGTCGCCCTGGTTGAAGGCGCGCAGCTGTGGACGAGAGACAAGCG
GTTGAAGGCTGCGTCGGTCGATGCGGGCATCGCACTCTTCGATGCCTGA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 6871.88 Da        Isoelectric Point: 11.6072

>AT62823 WP_036455532.1 NZ_CP015278:1511113-1511310 [Mycobacterium intracellulare subsp. chimaera]
MRTTVTIDDDLLAKAAELTGVRENVALLREGLQTLIRVESARRLAALGGTDAGAVAAPRRRRGTG

Download         Length: 198 bp

>AT62823 NZ_CP015278:1511113-1511310 [Mycobacterium intracellulare subsp. chimaera]
ATGCGGACCACAGTCACGATCGACGACGACCTGTTGGCCAAGGCTGCTGAGTTGACCGGCGTGCGCGAGAACGTCGCGTT
GCTCCGCGAGGGATTGCAGACGCTGATCAGGGTGGAAAGCGCTCGCCGACTTGCCGCGCTCGGCGGGACGGATGCCGGGG
CGGTGGCCGCTCCCCGGCGCCGCCGTGGGACTGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A081I0A5

Antitoxin

Source ID Structure
AlphaFold DB A0A081I0A4

References