62822

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 1509410..1509954 Replicon chromosome
Accession NZ_CP015278
Organism Mycobacterium intracellulare subsp. chimaera strain DSM 44623

Toxin (Protein)


Gene name relE Uniprot ID A0A854HUL3
Locus tag MYCODSM44623_RS07435 Protein ID WP_042910934.1
Coordinates 1509709..1509954 (+) Length 82 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S4Z4W6
Locus tag MYCODSM44623_RS07430 Protein ID WP_020821851.1
Coordinates 1509410..1509694 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MYCODSM44623_RS07405 1504484..1505083 - 600 WP_009953444.1 lipid droplet-associated protein -
MYCODSM44623_RS07410 1505173..1506171 + 999 WP_042910931.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
MYCODSM44623_RS07415 1506217..1507362 - 1146 WP_179945068.1 hypothetical protein -
MYCODSM44623_RS07420 1507492..1508565 + 1074 WP_042910932.1 redox-regulated ATPase YchF -
MYCODSM44623_RS07425 1508582..1509322 + 741 WP_042910933.1 aminoglycoside 3'-phosphotransferase -
MYCODSM44623_RS07430 1509410..1509694 + 285 WP_020821851.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MYCODSM44623_RS07435 1509709..1509954 + 246 WP_042910934.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MYCODSM44623_RS07440 1509990..1510541 + 552 WP_036454798.1 VOC family protein -
MYCODSM44623_RS07445 1510620..1511018 + 399 WP_036454800.1 VOC family protein -
MYCODSM44623_RS07450 1511113..1511310 + 198 WP_036455532.1 type II toxin-antitoxin system VapB family antitoxin -
MYCODSM44623_RS07455 1511307..1511675 + 369 WP_036454801.1 type II toxin-antitoxin system VapC family toxin -
MYCODSM44623_RS07460 1511858..1512199 + 342 WP_172417493.1 hypothetical protein -
MYCODSM44623_RS29755 1512285..1512644 + 360 WP_042910935.1 hypothetical protein -
MYCODSM44623_RS07470 1512829..1513404 + 576 WP_075630262.1 C40 family peptidase -
MYCODSM44623_RS07475 1513767..1514090 + 324 WP_036454806.1 antibiotic biosynthesis monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(29-80)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 82 a.a.        Molecular weight: 9380.95 Da        Isoelectric Point: 11.2612

>T62822 WP_042910934.1 NZ_CP015278:1509709-1509954 [Mycobacterium intracellulare subsp. chimaera]
MTAAAKRALTHLLPESVAIACWEFIRGPLAENPQRVGKPLRGQLEGRYSARRGEFRVIYRIFDERVVVPVIHIAHRRDVY
R

Download         Length: 246 bp

>T62822 NZ_CP015278:1509709-1509954 [Mycobacterium intracellulare subsp. chimaera]
ATGACGGCAGCTGCGAAGAGGGCGCTCACTCATTTGTTGCCCGAGTCGGTGGCCATTGCTTGCTGGGAGTTCATTCGGGG
TCCGCTCGCGGAGAACCCGCAGCGGGTGGGCAAGCCGCTTCGCGGCCAGTTGGAAGGGCGATACTCGGCGCGCAGGGGCG
AGTTTCGCGTCATTTACCGGATCTTCGACGAACGGGTGGTGGTCCCCGTCATCCACATCGCGCATCGCCGCGACGTTTAC
CGGTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10513.88 Da        Isoelectric Point: 4.3705

>AT62822 WP_020821851.1 NZ_CP015278:1509410-1509694 [Mycobacterium intracellulare subsp. chimaera]
MSTLPLAEVRANLSKLVDEAVRTHERIEVTRQGRRAAVILSADDFDSIMETLAILSDQDLMREVRAAESEAEDGALYTLD
QVTEEMRAVGRLPR

Download         Length: 285 bp

>AT62822 NZ_CP015278:1509410-1509694 [Mycobacterium intracellulare subsp. chimaera]
ATGTCGACGCTTCCGCTGGCCGAGGTCCGAGCCAACCTTTCCAAGCTGGTCGACGAGGCCGTCCGGACCCATGAGCGCAT
CGAGGTCACCAGGCAAGGTCGCCGCGCGGCGGTGATTCTCAGCGCGGATGACTTCGATTCGATTATGGAAACTCTGGCCA
TCCTCAGCGATCAAGACTTGATGCGCGAAGTCCGAGCGGCAGAGTCAGAGGCAGAGGACGGCGCGCTCTACACACTCGAT
CAGGTGACCGAGGAGATGCGTGCTGTCGGCCGGCTCCCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A854HUL3

Antitoxin

Source ID Structure
AlphaFold DB S4Z4W6

References