Detailed information of TA system TA062820

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PHD(antitoxin)
• Location: 1044546..1045229
• Replicon: chromosome
• Accession: NZ_CP015278
• Organism: Mycobacterium intracellulare subsp. chimaera strain DSM 44623

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: D5PEA4
• Locus tag: MYCODSM44623_RS05145
• Protein ID: WP_007168487.1
• Coordinates: 1044546..1044953 (-)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A1X1XBB9
• Locus tag: MYCODSM44623_RS05150
• Protein ID: WP_033711258.1
• Coordinates: 1044957..1045229 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MYCODSM44623_RS05120	1040528..1041592	+	1065	WP_042910040.1	IS110 family transposase	-
MYCODSM44623_RS05125	1041899..1042069	-	171	Protein_1006	carnitinyl-CoA dehydratase	-
MYCODSM44623_RS05135	1043818..1044123	-	306	WP_007168485.1	hypothetical protein	-
MYCODSM44623_RS05140	1044184..1044525	-	342	WP_007168486.1	hypothetical protein	-
MYCODSM44623_RS05145	1044546..1044953	-	408	WP_007168487.1	type II toxin-antitoxin system VapC family toxin	Toxin
MYCODSM44623_RS05150	1044957..1045229	-	273	WP_033711258.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
MYCODSM44623_RS05160	1045725..1046960	-	1236	WP_042909886.1	IS256 family transposase	-
MYCODSM44623_RS28965	1047602..1047787	+	186	WP_132160383.1	hypothetical protein	-
MYCODSM44623_RS05165	1047861..1048277	-	417	WP_007168492.1	type II toxin-antitoxin system VapC family toxin	-
MYCODSM44623_RS05170	1048274..1048525	-	252	WP_007168493.1	ribbon-helix-helix protein, CopG family	-
MYCODSM44623_RS05180	1049327..1049722	+	396	WP_007168495.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1014083..1066538	52455
	-	flank	IS/Tn	-	-	1045725..1046960	1235

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-121)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 14464.55 Da
• Isoelectric Point: 4.6697

>T62820 WP_007168487.1 NZ_CP015278:c1044953-1044546 [Mycobacterium intracellulare subsp. chimaera]
VIYLDTSALVKLIRIEVESDALADWLDERTETRWITSALAEVELPRAIRAVAPNGLSAVPSVLARLDRFEIDQVIRATAA
AYPDPALRSLDAIHLATAQIAASTAPLTAMVAYDSRLSDAARALGITIVTPGRNS

Nucleotide

• Length: 408 bp

>T62820 NZ_CP015278:c1044953-1044546 [Mycobacterium intracellulare subsp. chimaera]
GTGATCTACCTGGATACCTCGGCTCTGGTCAAGCTGATCCGGATCGAAGTCGAATCTGATGCTCTAGCTGACTGGCTCGA
TGAACGCACCGAAACACGTTGGATAACATCTGCCTTGGCTGAAGTGGAGCTCCCCAGAGCCATCCGCGCAGTCGCCCCAA
ATGGCTTATCTGCTGTCCCCTCTGTGCTGGCCAGACTGGATCGGTTCGAAATCGACCAGGTCATCCGCGCCACCGCGGCC
GCCTACCCCGATCCGGCGCTGCGCTCGCTCGATGCGATACACCTGGCCACCGCTCAAATCGCCGCATCCACAGCACCATT
GACCGCCATGGTCGCCTATGACAGTCGACTCAGCGACGCCGCCCGTGCCCTCGGGATAACGATTGTCACACCTGGAAGAA
ACTCATGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 9764.35 Da
• Isoelectric Point: 8.7382

>AT62820 WP_033711258.1 NZ_CP015278:c1045229-1044957 [Mycobacterium intracellulare subsp. chimaera]
MSEVPLRMLNQETAKVLARVKRGEEITLTERGEVIARIIPATAGPLDALITAGRVQPATLAGPAPRPTVPMHDNLDAGAL
LQRLRAEERY

Nucleotide

• Length: 273 bp

>AT62820 NZ_CP015278:c1045229-1044957 [Mycobacterium intracellulare subsp. chimaera]
ATGAGTGAAGTACCTCTCCGAATGCTCAACCAAGAGACGGCAAAGGTCTTGGCCCGCGTCAAGCGTGGCGAAGAGATCAC
GCTTACTGAGCGCGGGGAAGTCATCGCCCGAATAATCCCCGCTACCGCCGGCCCACTGGATGCGTTGATCACTGCCGGCA
GAGTGCAACCGGCGACGCTGGCCGGCCCAGCCCCGCGGCCGACCGTTCCGATGCACGACAATCTCGACGCCGGCGCGCTA
TTGCAACGTCTGCGCGCCGAGGAAAGGTATTAG

Structures

Toxin

• AlphaFold DB: A0A1X1XAJ9

Antitoxin

• AlphaFold DB: A0A1X1XBB9