62819

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 978271..978938 Replicon chromosome
Accession NZ_CP015278
Organism Mycobacterium intracellulare subsp. chimaera strain DSM 44623

Toxin (Protein)


Gene name vapC Uniprot ID D5PE24
Locus tag MYCODSM44623_RS04805 Protein ID WP_007168407.1
Coordinates 978546..978938 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID D5PE23
Locus tag MYCODSM44623_RS04800 Protein ID WP_007168406.1
Coordinates 978271..978546 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MYCODSM44623_RS29485 973775..974101 - 327 WP_033711234.1 hypothetical protein -
MYCODSM44623_RS04775 974091..974324 - 234 Protein_934 transposase -
MYCODSM44623_RS04780 974342..975553 - 1212 Protein_935 ISL3 family transposase -
MYCODSM44623_RS04785 975692..976324 - 633 Protein_936 DDE-type integrase/transposase/recombinase -
MYCODSM44623_RS28935 976276..976416 - 141 WP_145958858.1 SDR family oxidoreductase -
MYCODSM44623_RS04790 976460..977163 - 704 Protein_938 histidine phosphatase family protein -
MYCODSM44623_RS04795 977246..978118 + 873 WP_007168405.1 MaoC family dehydratase N-terminal domain-containing protein -
MYCODSM44623_RS04800 978271..978546 + 276 WP_007168406.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MYCODSM44623_RS04805 978546..978938 + 393 WP_007168407.1 type II toxin-antitoxin system VapC family toxin Toxin
MYCODSM44623_RS04810 979086..980245 - 1160 Protein_942 trehalose-phosphatase -
MYCODSM44623_RS04815 980287..981625 - 1339 Protein_943 DUF1298 domain-containing protein -
MYCODSM44623_RS28940 981886..982008 - 123 Protein_944 IS1595 family transposase -
MYCODSM44623_RS04825 982344..983678 + 1335 Protein_945 IS1182 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-119)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-45)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14305.73 Da        Isoelectric Point: 10.5032

>T62819 WP_007168407.1 NZ_CP015278:978546-978938 [Mycobacterium intracellulare subsp. chimaera]
MAAIYLDSSAIVKLAVREPESDALRRYLRTRLPRVSSALARTEVMRALLHKGESARRAGRRALASLDLLRIDNRLLDLAG
GLLPIELRTLDAIHLATAQRLGMDLGRLCTYDDRMRDAAEALGMAVIAPS

Download         Length: 393 bp

>T62819 NZ_CP015278:978546-978938 [Mycobacterium intracellulare subsp. chimaera]
ATGGCGGCCATCTACCTGGACTCGTCCGCAATCGTCAAGCTTGCAGTTCGTGAGCCAGAGTCGGATGCGCTGCGTCGCTA
CCTTCGCACCCGGCTGCCGCGGGTGTCGAGTGCCCTTGCGCGGACGGAGGTCATGCGGGCTCTGCTCCACAAGGGTGAAT
CAGCCCGAAGAGCCGGACGCCGGGCGCTCGCGAGCCTAGACCTACTACGCATCGACAACCGATTGCTCGATCTTGCTGGT
GGGCTGCTGCCAATCGAGCTACGCACCCTCGATGCAATTCACCTGGCGACTGCCCAGCGGCTCGGCATGGATCTTGGCCG
GTTGTGCACTTACGACGACCGCATGCGCGACGCCGCCGAGGCGCTCGGCATGGCAGTGATTGCCCCGTCTTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10150.63 Da        Isoelectric Point: 5.1881

>AT62819 WP_007168406.1 NZ_CP015278:978271-978546 [Mycobacterium intracellulare subsp. chimaera]
MSTVGVRELRQRASELLRRVEAGETIEITDRGRPIALLSPMPEGGPYQQMLASGGIERATLDFDDLPEPVRLKTGIELPS
VTLARLREHER

Download         Length: 276 bp

>AT62819 NZ_CP015278:978271-978546 [Mycobacterium intracellulare subsp. chimaera]
ATGTCTACGGTGGGCGTTCGTGAGCTGCGGCAGCGGGCCAGCGAACTCCTCCGTCGGGTCGAGGCCGGCGAGACGATCGA
GATCACCGACCGTGGTCGGCCTATCGCCCTTCTCTCGCCGATGCCGGAGGGCGGTCCGTACCAGCAGATGCTGGCAAGCG
GCGGGATCGAACGTGCGACGCTTGACTTTGATGACCTTCCCGAGCCGGTCCGACTCAAAACGGGTATCGAGCTGCCGTCC
GTGACGCTTGCGCGCCTGCGTGAGCACGAGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X1XV84

Antitoxin

Source ID Structure
AlphaFold DB A0A1X1XUZ3

References