62818

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Rv0298-Rv0299/-
Location 767619..768148 Replicon chromosome
Accession NZ_CP015278
Organism Mycobacterium intracellulare subsp. chimaera strain DSM 44623

Toxin (Protein)


Gene name Rv0299 Uniprot ID X7VD93
Locus tag MYCODSM44623_RS03870 Protein ID WP_007172144.1
Coordinates 767619..767924 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name Rv0298 Uniprot ID A0A1X1WNE2
Locus tag MYCODSM44623_RS03875 Protein ID WP_042910679.1
Coordinates 767921..768148 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MYCODSM44623_RS03855 763517..764542 - 1026 WP_007172501.1 TniB family NTP-binding protein -
MYCODSM44623_RS03860 764530..766488 - 1959 WP_033719466.1 DDE-type integrase/transposase/recombinase -
MYCODSM44623_RS03865 766611..767300 - 690 WP_046182418.1 TnsA-like heteromeric transposase endonuclease subunit -
MYCODSM44623_RS03870 767619..767924 - 306 WP_007172144.1 hypothetical protein Toxin
MYCODSM44623_RS03875 767921..768148 - 228 WP_042910679.1 ribbon-helix-helix protein, CopG family Antitoxin
MYCODSM44623_RS03885 768634..770124 + 1491 WP_007172147.1 type VII secretion protein EccB -
MYCODSM44623_RS03890 770198..771253 + 1056 WP_007172148.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Ribbon-helix-helix protein, CopG

(6-41)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 10428.23 Da        Isoelectric Point: 3.9382

>T62818 WP_007172144.1 NZ_CP015278:c767924-767619 [Mycobacterium intracellulare subsp. chimaera]
VITPGDITPGRDTNQELYVVVLSNTIHLAAATGQVIICPFIPGEIPSSTMAMIVTVLQPKGVVLPELIQWLPVAALDQPI
GNIGGIALADTTTTAVTALIS

Download         Length: 306 bp

>T62818 NZ_CP015278:c767924-767619 [Mycobacterium intracellulare subsp. chimaera]
GTGATCACACCCGGAGACATCACGCCAGGCCGCGACACCAACCAGGAACTGTACGTTGTCGTACTATCTAACACGATTCA
CCTCGCAGCCGCCACCGGCCAGGTGATCATCTGCCCCTTCATTCCCGGTGAAATCCCCAGCAGCACAATGGCTATGATCG
TCACAGTGCTGCAACCCAAAGGGGTTGTCTTACCGGAGCTCATCCAGTGGCTTCCTGTCGCGGCCCTCGACCAACCCATC
GGCAATATCGGCGGCATCGCGCTCGCTGACACGACCACGACCGCCGTCACCGCGCTCATTTCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8167.24 Da        Isoelectric Point: 5.0079

>AT62818 WP_042910679.1 NZ_CP015278:c768148-767921 [Mycobacterium intracellulare subsp. chimaera]
MAKAKVSVMIEEAVLAAADADAQAAGLNRSEMIERALHNEHLRISLENYTTHTVPTLDIDAYAEKIYQANRAAGL

Download         Length: 228 bp

>AT62818 NZ_CP015278:c768148-767921 [Mycobacterium intracellulare subsp. chimaera]
ATGGCGAAAGCCAAAGTGTCCGTAATGATTGAAGAGGCCGTGCTGGCGGCGGCCGATGCGGACGCCCAGGCGGCCGGGCT
GAATCGTTCAGAGATGATCGAACGAGCCCTGCACAACGAGCATCTCCGAATCTCGCTCGAGAACTACACAACACACACTG
TGCCAACGCTCGACATCGACGCCTACGCGGAGAAGATCTATCAGGCGAACCGGGCCGCTGGCCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X1XDZ0

Antitoxin

Source ID Structure
AlphaFold DB A0A1X1WNE2

References