Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 85763..86445 Replicon plasmid unnamed 1
Accession NZ_CP015273
Organism Mycobacterium intracellulare subsp. chimaera strain ZUERICH-1

Toxin (Protein)


Gene name vapC Uniprot ID A0A854IDQ2
Locus tag MYCOZU1_RS29340 Protein ID WP_040624374.1
Coordinates 86029..86445 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID D5P579
Locus tag MYCOZU1_RS29335 Protein ID WP_007172349.1
Coordinates 85763..86026 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MYCOZU1_RS29315 80835..82280 - 1446 WP_101930849.1 type VII secretion protein EccB -
MYCOZU1_RS29320 82394..83434 - 1041 WP_023363502.1 C40 family peptidase -
MYCOZU1_RS29325 83520..84623 - 1104 WP_051404593.1 hypothetical protein -
MYCOZU1_RS29330 84687..85550 - 864 WP_142383462.1 hypothetical protein -
MYCOZU1_RS29335 85763..86026 + 264 WP_007172349.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MYCOZU1_RS29340 86029..86445 + 417 WP_040624374.1 type II toxin-antitoxin system VapC family toxin Toxin
MYCOZU1_RS29345 86727..88058 - 1332 WP_023363507.1 IS256 family transposase -
MYCOZU1_RS29350 88201..88782 + 582 WP_007172352.1 IS607 family transposase -
MYCOZU1_RS29355 88782..90182 + 1401 Protein_90 transposase -
MYCOZU1_RS29360 90239..91411 - 1173 WP_080691094.1 DDE-type integrase/transposase/recombinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - eccA5 / esxN 1..97267 97267


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(1-82)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14879.84 Da        Isoelectric Point: 5.4519

>T62816 WP_040624374.1 NZ_CP015273:86029-86445 [Mycobacterium intracellulare subsp. chimaera]
MIIDSSAIVALIQGEDPYTEQIAAAIAADPSPVMSTANAAECLIVLTNRHGATARTVFDRLRSEINLGFQPFTLEHAIAA
HRAYLHYGKGRHPAALNYGDTMAYATAKLAHEPLIAIGNDFTQTDLEFNGVIGYWPAP

Download         Length: 417 bp

>T62816 NZ_CP015273:86029-86445 [Mycobacterium intracellulare subsp. chimaera]
CTGATCATCGACTCTTCCGCGATCGTCGCCCTCATCCAGGGCGAGGACCCCTACACCGAACAGATCGCGGCCGCCATCGC
CGCCGATCCCAGCCCCGTCATGTCCACGGCCAACGCAGCCGAATGCCTCATCGTTCTCACCAACCGACACGGCGCGACCG
CGCGCACCGTCTTCGACCGCCTACGATCCGAAATCAACCTCGGCTTCCAGCCCTTCACCCTCGAACACGCGATCGCCGCC
CACCGCGCCTACCTCCACTACGGAAAAGGCCGCCACCCCGCCGCCCTCAACTACGGCGACACCATGGCCTACGCCACCGC
CAAACTCGCACACGAACCCCTCATCGCCATCGGCAACGACTTCACCCAAACCGACCTCGAATTCAACGGCGTCATCGGCT
ACTGGCCAGCGCCCTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9884.20 Da        Isoelectric Point: 4.8359

>AT62816 WP_007172349.1 NZ_CP015273:85763-86026 [Mycobacterium intracellulare subsp. chimaera]
MAFNVKDEEVIRFADELAARLHLPSRIDAIRYALRAQIEVTQSRTANRSAELLDVLKTEIWPLLDDRSPITKTEREQALG
YDTATGV

Download         Length: 264 bp

>AT62816 NZ_CP015273:85763-86026 [Mycobacterium intracellulare subsp. chimaera]
ATGGCTTTCAACGTGAAAGACGAAGAGGTCATCCGCTTCGCAGACGAGCTCGCCGCGCGCCTCCACCTCCCCAGCCGCAT
CGACGCCATCCGCTACGCCCTGCGAGCCCAGATCGAAGTCACCCAATCCCGCACCGCAAACCGCTCCGCAGAACTGCTCG
ACGTCCTCAAAACCGAGATCTGGCCACTACTGGACGACCGATCCCCAATCACCAAAACCGAACGCGAACAAGCCCTCGGA
TACGACACAGCAACGGGAGTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A854IDQ2

Antitoxin

Source ID Structure
AlphaFold DB A0A1Y0TBQ2

References