Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-YefM
Location 17733..18271 Replicon plasmid unnamed 1
Accession NZ_CP015273
Organism Mycobacterium intracellulare subsp. chimaera strain ZUERICH-1

Toxin (Protein)


Gene name relE Uniprot ID D5P5D7
Locus tag MYCOZU1_RS29000 Protein ID WP_007172405.1
Coordinates 18014..18271 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID M1FTM7
Locus tag MYCOZU1_RS28995 Protein ID WP_007172404.1
Coordinates 17733..18017 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MYCOZU1_RS28975 12866..14386 - 1521 WP_007172379.1 DUF4226 domain-containing protein -
MYCOZU1_RS28980 14608..15468 - 861 WP_023363522.1 DUF2637 domain-containing protein -
MYCOZU1_RS28985 16165..16887 + 723 WP_139315444.1 ParA family protein -
MYCOZU1_RS30345 16890..17651 + 762 WP_023363524.1 hypothetical protein -
MYCOZU1_RS28995 17733..18017 + 285 WP_007172404.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MYCOZU1_RS29000 18014..18271 + 258 WP_007172405.1 Txe/YoeB family addiction module toxin Toxin
MYCOZU1_RS29005 18486..18779 - 294 WP_007172406.1 hypothetical protein -
MYCOZU1_RS29010 18796..19794 - 999 WP_101930848.1 hypothetical protein -
MYCOZU1_RS29015 20506..21075 + 570 WP_007172408.1 hypothetical protein -
MYCOZU1_RS29020 21065..22165 + 1101 WP_007172409.1 tyrosine-type recombinase/integrase -
MYCOZU1_RS29025 22284..22496 + 213 WP_007172410.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - eccA5 / esxN 1..97267 97267


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-70)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10156.56 Da        Isoelectric Point: 9.8613

>T62815 WP_007172405.1 NZ_CP015273:18014-18271 [Mycobacterium intracellulare subsp. chimaera]
VRSINFDPAAWEDFLFWLASDRKTARRITRLIAEIQRNPFAGIGKPEPLKGELSGYWSRRIDDEHRIVYRADDHEIKILK
ARYHY

Download         Length: 258 bp

>T62815 NZ_CP015273:18014-18271 [Mycobacterium intracellulare subsp. chimaera]
GTGAGAAGCATCAACTTCGATCCCGCCGCGTGGGAGGACTTTCTATTTTGGCTGGCTTCCGACCGCAAAACAGCACGGCG
CATCACCAGACTCATCGCAGAAATCCAGCGCAACCCGTTTGCTGGGATTGGAAAACCAGAACCGCTCAAGGGTGAACTAT
CCGGGTACTGGTCGCGGCGCATCGACGACGAACACCGGATCGTCTACCGCGCAGATGATCACGAAATCAAGATCCTCAAA
GCCCGATACCACTACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10455.62 Da        Isoelectric Point: 4.3885

>AT62815 WP_007172404.1 NZ_CP015273:17733-18017 [Mycobacterium intracellulare subsp. chimaera]
MAISASEARQRLFPLLEQVNTDHEPVRITSKAGDAVLMSAADYDSWQETVYLLRSPENARRLMEAVARDNATRPTPGSYT
KSIDELEEMAGGQE

Download         Length: 285 bp

>AT62815 NZ_CP015273:17733-18017 [Mycobacterium intracellulare subsp. chimaera]
ATGGCTATCAGTGCAAGTGAGGCCCGGCAGCGCCTCTTTCCGCTGCTTGAACAAGTCAACACCGACCACGAGCCTGTGCG
AATTACGTCCAAGGCCGGAGATGCAGTGCTCATGTCGGCCGCTGACTACGATTCGTGGCAAGAAACGGTCTACCTCCTGC
GTTCCCCCGAGAATGCCCGCCGACTCATGGAGGCCGTCGCCCGAGACAACGCCACCCGGCCCACCCCCGGCAGCTACACC
AAGTCGATCGACGAACTCGAGGAGATGGCCGGCGGCCAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Y0THX2

Antitoxin

Source ID Structure
AlphaFold DB M1FTM7

References