Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2790..3331 Replicon plasmid unnamed 1
Accession NZ_CP015273
Organism Mycobacterium intracellulare subsp. chimaera strain ZUERICH-1

Toxin (Protein)


Gene name parE Uniprot ID D5P595
Locus tag MYCOZU1_RS28915 Protein ID WP_007172365.1
Coordinates 2790..3083 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A854I1S2
Locus tag MYCOZU1_RS28920 Protein ID WP_040624378.1
Coordinates 3080..3331 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MYCOZU1_RS28905 1153..1851 - 699 WP_139315442.1 hypothetical protein -
MYCOZU1_RS28910 1865..2572 - 708 WP_139315443.1 hypothetical protein -
MYCOZU1_RS28915 2790..3083 - 294 WP_007172365.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MYCOZU1_RS28920 3080..3331 - 252 WP_040624378.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
MYCOZU1_RS28925 3437..3943 - 507 WP_007172367.1 helix-turn-helix domain-containing protein -
MYCOZU1_RS28930 4250..4687 + 438 WP_007172368.1 WhiB family transcriptional regulator -
MYCOZU1_RS30340 4743..5333 + 591 WP_023363514.1 hypothetical protein -
MYCOZU1_RS28935 5296..5580 + 285 WP_007172369.1 hypothetical protein -
MYCOZU1_RS28940 5957..7819 + 1863 WP_023363516.1 helicase associated domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - eccA5 / esxN 1..97267 97267


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin

Antitoxin ParD

(2-79)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11261.74 Da        Isoelectric Point: 6.9772

>T62814 WP_007172365.1 NZ_CP015273:c3083-2790 [Mycobacterium intracellulare subsp. chimaera]
VSAYVLSPAAQADLEQIWDYTHEHWGLDQAEQYLRELQRAIERAAANPRIGRACDEIRPGYRKLAAGSHMLFYRVTTQGF
LDVVRVLHQRMDVDRHL

Download         Length: 294 bp

>T62814 NZ_CP015273:c3083-2790 [Mycobacterium intracellulare subsp. chimaera]
GTGAGCGCATACGTCCTTTCACCCGCTGCGCAAGCAGATTTGGAACAGATCTGGGACTACACGCACGAGCACTGGGGCCT
GGATCAGGCTGAGCAGTACCTGCGAGAACTTCAACGCGCTATCGAGCGCGCAGCGGCGAACCCCCGGATCGGGCGGGCCT
GCGACGAGATCCGCCCGGGCTATCGCAAGCTGGCAGCCGGGTCGCACATGCTGTTTTATCGGGTGACAACCCAAGGCTTC
CTCGATGTCGTGCGTGTCCTGCACCAACGCATGGACGTCGACCGCCACCTTTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9203.22 Da        Isoelectric Point: 5.8579

>AT62814 WP_040624378.1 NZ_CP015273:c3331-3080 [Mycobacterium intracellulare subsp. chimaera]
VGKNTSFSLDEHYSAFIEAEVAAGRYRSASDVVRSALRLLEDREIQLRALREALVAGERSGTSTPFDFDAFLDGKRAEKP
QGR

Download         Length: 252 bp

>AT62814 NZ_CP015273:c3331-3080 [Mycobacterium intracellulare subsp. chimaera]
GTGGGTAAAAACACGTCCTTCAGTCTCGATGAGCATTACAGCGCCTTCATTGAGGCTGAGGTGGCTGCGGGACGTTACCG
GTCGGCCAGTGATGTCGTGCGCTCCGCGTTGCGGTTACTCGAGGACCGTGAAATTCAGCTTCGGGCACTGCGCGAGGCGC
TAGTGGCCGGTGAGCGCAGCGGCACTTCAACACCGTTTGACTTCGACGCCTTCCTCGACGGCAAACGCGCCGAAAAGCCG
CAAGGCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Y0TBP0

Antitoxin

Source ID Structure
AlphaFold DB A0A854I1S2

References