Detailed information of TA system TA062808

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 1600372..1600916
• Replicon: chromosome
• Accession: NZ_CP015272
• Organism: Mycobacterium intracellulare subsp. chimaera strain ZUERICH-1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A854HUL3
• Locus tag: MYCOZU1_RS07900
• Protein ID: WP_042910934.1
• Coordinates: 1600671..1600916 (+)
• Length: 82 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: S4Z4W6
• Locus tag: MYCOZU1_RS07895
• Protein ID: WP_020821851.1
• Coordinates: 1600372..1600656 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MYCOZU1_RS07870	1595446..1596045	-	600	WP_009953444.1	lipid droplet-associated protein	-
MYCOZU1_RS07875	1596135..1597133	+	999	WP_042910931.1	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	-
MYCOZU1_RS07880	1597179..1598324	-	1146	WP_179945068.1	hypothetical protein	-
MYCOZU1_RS07885	1598454..1599527	+	1074	WP_042910932.1	redox-regulated ATPase YchF	-
MYCOZU1_RS07890	1599544..1600284	+	741	WP_042910933.1	aminoglycoside 3'-phosphotransferase	-
MYCOZU1_RS07895	1600372..1600656	+	285	WP_020821851.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MYCOZU1_RS07900	1600671..1600916	+	246	WP_042910934.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MYCOZU1_RS07905	1600952..1601503	+	552	WP_036454798.1	VOC family protein	-
MYCOZU1_RS07910	1601582..1601980	+	399	WP_036454800.1	VOC family protein	-
MYCOZU1_RS07915	1602075..1602272	+	198	WP_036455532.1	type II toxin-antitoxin system VapB family antitoxin	-
MYCOZU1_RS07920	1602269..1602637	+	369	WP_036454801.1	type II toxin-antitoxin system VapC family toxin	-
MYCOZU1_RS07925	1602820..1603161	+	342	WP_172417493.1	hypothetical protein	-
MYCOZU1_RS30545	1603247..1603606	+	360	WP_042910935.1	hypothetical protein	-
MYCOZU1_RS07935	1603791..1604366	+	576	WP_075630262.1	C40 family peptidase	-
MYCOZU1_RS07940	1604729..1605052	+	324	WP_036454806.1	antibiotic biosynthesis monooxygenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (29-80)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-71)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9380.95 Da
• Isoelectric Point: 11.2612

>T62808 WP_042910934.1 NZ_CP015272:1600671-1600916 [Mycobacterium intracellulare subsp. chimaera]
MTAAAKRALTHLLPESVAIACWEFIRGPLAENPQRVGKPLRGQLEGRYSARRGEFRVIYRIFDERVVVPVIHIAHRRDVY
R

Nucleotide

• Length: 246 bp

>T62808 NZ_CP015272:1600671-1600916 [Mycobacterium intracellulare subsp. chimaera]
ATGACGGCAGCTGCGAAGAGGGCGCTCACTCATTTGTTGCCCGAGTCGGTGGCCATTGCTTGCTGGGAGTTCATTCGGGG
TCCGCTCGCGGAGAACCCGCAGCGGGTGGGCAAGCCGCTTCGCGGCCAGTTGGAAGGGCGATACTCGGCGCGCAGGGGCG
AGTTTCGCGTCATTTACCGGATCTTCGACGAACGGGTGGTGGTCCCCGTCATCCACATCGCGCATCGCCGCGACGTTTAC
CGGTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10513.88 Da
• Isoelectric Point: 4.3705

>AT62808 WP_020821851.1 NZ_CP015272:1600372-1600656 [Mycobacterium intracellulare subsp. chimaera]
MSTLPLAEVRANLSKLVDEAVRTHERIEVTRQGRRAAVILSADDFDSIMETLAILSDQDLMREVRAAESEAEDGALYTLD
QVTEEMRAVGRLPR

Nucleotide

• Length: 285 bp

>AT62808 NZ_CP015272:1600372-1600656 [Mycobacterium intracellulare subsp. chimaera]
ATGTCGACGCTTCCGCTGGCCGAGGTCCGAGCCAACCTTTCCAAGCTGGTCGACGAGGCCGTCCGGACCCATGAGCGCAT
CGAGGTCACCAGGCAAGGTCGCCGCGCGGCGGTGATTCTCAGCGCGGATGACTTCGATTCGATTATGGAAACTCTGGCCA
TCCTCAGCGATCAAGACTTGATGCGCGAAGTCCGAGCGGCAGAGTCAGAGGCAGAGGACGGCGCGCTCTACACACTCGAT
CAGGTGACCGAGGAGATGCGTGCTGTCGGCCGGCTCCCGCGGTGA

Structures

Toxin

• AlphaFold DB: A0A854HUL3

Antitoxin

• AlphaFold DB: S4Z4W6