Detailed information of TA system TA062807

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): unclassified/Polyketide_cyc2(toxin)
• Location: 1358421..1359074
• Replicon: chromosome
• Accession: NZ_CP015272
• Organism: Mycobacterium intracellulare subsp. chimaera strain ZUERICH-1

Toxin (Protein)

• Gene name: novel[antitoxin]
• Uniprot ID: -
• Locus tag: MYCOZU1_RS06760
• Protein ID: WP_008253911.1
• Coordinates: 1358613..1359074 (+)
• Length: 154 a.a.

Antitoxin (Protein)

• Gene name: novel[toxin]
• Uniprot ID: X8A187
• Locus tag: MYCOZU1_RS06755
• Protein ID: WP_009957321.1
• Coordinates: 1358421..1358609 (+)
• Length: 63 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MYCOZU1_RS06745	1354394..1355971	+	1578	WP_042911067.1	serine hydrolase	-
MYCOZU1_RS06750	1355968..1358355	+	2388	WP_042910814.1	cation-translocating P-type ATPase	-
MYCOZU1_RS06755	1358421..1358609	+	189	WP_009957321.1	antitoxin	Antitoxin
MYCOZU1_RS06760	1358613..1359074	+	462	WP_008253911.1	SRPBCC family protein	Toxin
MYCOZU1_RS06765	1359161..1359931	+	771	WP_042910815.1	VOC family protein	-
MYCOZU1_RS06770	1360005..1360439	+	435	WP_008253914.1	hypothetical protein	-
MYCOZU1_RS06775	1360444..1360932	-	489	WP_036454690.1	glyoxalase/bleomycin resistance/dioxygenase family protein	-
MYCOZU1_RS06780	1360932..1362446	-	1515	WP_042910816.1	carotenoid oxygenase family protein	-
MYCOZU1_RS06785	1362449..1363669	-	1221	WP_042910817.1	acetyl-CoA acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Polyketide cyclase/dehydrase (1-142)

Antitoxin

• Antitoxin Rv0909/MT0933 (4-52)

Sequences

Toxin

Protein

• Length: 154 a.a.
• Molecular weight: 16639.20 Da
• Isoelectric Point: 8.5617

>T62807 WP_008253911.1 NZ_CP015272:1358613-1359074 [Mycobacterium intracellulare subsp. chimaera]
MAKLSGSIDVPLPPEVAWQHASDLSRYKDWLTIHRVWRSALPDEIEKGSVVESIVEVKGMPNRIKWTVVRYKPPEGMTLN
GDGVGGVKVKLMAKIQPKGDGSLVSFDVHLGGPALFGPIGMIVAAALRGDIDQSLENFVTVFTRPDPSSNGHR

Nucleotide

• Length: 462 bp

>T62807 NZ_CP015272:1358613-1359074 [Mycobacterium intracellulare subsp. chimaera]
ATGGCCAAGCTTTCCGGATCCATCGATGTCCCGCTGCCGCCCGAGGTGGCCTGGCAGCACGCCTCCGACCTGTCCCGGTA
CAAGGATTGGCTGACTATCCACCGGGTGTGGCGCAGCGCATTGCCCGACGAGATCGAGAAGGGCTCGGTCGTCGAGTCGA
TCGTCGAGGTCAAGGGCATGCCCAACCGGATCAAATGGACGGTCGTGCGCTACAAGCCACCCGAGGGCATGACGCTCAAC
GGCGACGGAGTCGGCGGGGTCAAGGTCAAGCTGATGGCCAAGATCCAGCCCAAAGGGGACGGCTCCCTCGTCAGTTTCGA
CGTGCACCTCGGTGGCCCCGCACTGTTCGGCCCCATCGGCATGATCGTCGCCGCCGCACTGCGCGGCGATATCGACCAGT
CGCTGGAGAACTTCGTGACGGTGTTCACCCGGCCCGATCCGAGCAGCAACGGGCATCGCTGA

Antitoxin

Protein

• Length: 63 a.a.
• Molecular weight: 6698.30 Da
• Isoelectric Point: 4.4702

>AT62807 WP_009957321.1 NZ_CP015272:1358421-1358609 [Mycobacterium intracellulare subsp. chimaera]
MGFLDKAKDLLSQNADKVETAIDKAGEFVDEKTQGKYSDTIHQVQEQAKKAAGAADTGDQQN

Nucleotide

• Length: 189 bp

>AT62807 NZ_CP015272:1358421-1358609 [Mycobacterium intracellulare subsp. chimaera]
ATGGGATTCCTGGACAAGGCCAAGGATCTGTTGTCGCAGAACGCCGACAAGGTCGAGACGGCCATCGACAAGGCGGGCGA
GTTCGTCGACGAAAAGACGCAGGGCAAATACTCCGACACCATTCACCAGGTGCAGGAGCAGGCGAAGAAGGCGGCCGGCG
CCGCGGACACGGGCGACCAGCAGAACTGA

Structures

Antitoxin

• AlphaFold DB: X8A187