Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/PHD(antitoxin) |
| Location | 1137109..1137792 | Replicon | chromosome |
| Accession | NZ_CP015272 | ||
| Organism | Mycobacterium intracellulare subsp. chimaera strain ZUERICH-1 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | D5PEA4 |
| Locus tag | MYCOZU1_RS05615 | Protein ID | WP_007168487.1 |
| Coordinates | 1137109..1137516 (-) | Length | 136 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | A0A1X1XBB9 |
| Locus tag | MYCOZU1_RS05620 | Protein ID | WP_033711258.1 |
| Coordinates | 1137520..1137792 (-) | Length | 91 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MYCOZU1_RS30525 | 1132390..1132605 | + | 216 | WP_158514285.1 | hypothetical protein | - |
| MYCOZU1_RS30530 | 1132544..1132789 | + | 246 | WP_080711236.1 | hypothetical protein | - |
| MYCOZU1_RS05585 | 1132765..1133076 | + | 312 | WP_075362207.1 | transposase | - |
| MYCOZU1_RS05590 | 1133092..1134345 | + | 1254 | WP_101930934.1 | IS30 family transposase | - |
| MYCOZU1_RS05595 | 1134462..1134632 | - | 171 | Protein_1103 | carnitinyl-CoA dehydratase | - |
| MYCOZU1_RS30040 | 1134790..1134933 | + | 144 | WP_155250266.1 | hypothetical protein | - |
| MYCOZU1_RS05605 | 1136381..1136686 | - | 306 | WP_007168485.1 | hypothetical protein | - |
| MYCOZU1_RS05610 | 1136747..1137088 | - | 342 | WP_007168486.1 | hypothetical protein | - |
| MYCOZU1_RS05615 | 1137109..1137516 | - | 408 | WP_007168487.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| MYCOZU1_RS05620 | 1137520..1137792 | - | 273 | WP_033711258.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | Antitoxin |
| MYCOZU1_RS05630 | 1138288..1139523 | - | 1236 | WP_042909886.1 | IS256 family transposase | - |
| MYCOZU1_RS30045 | 1140165..1140350 | + | 186 | WP_132160383.1 | hypothetical protein | - |
| MYCOZU1_RS05635 | 1140424..1140840 | - | 417 | WP_007168492.1 | type II toxin-antitoxin system VapC family toxin | - |
| MYCOZU1_RS05640 | 1140837..1141088 | - | 252 | WP_007168493.1 | ribbon-helix-helix protein, CopG family | - |
| MYCOZU1_RS05650 | 1141890..1142285 | + | 396 | WP_007168495.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1116467..1159101 | 42634 | |
| - | flank | IS/Tn | - | - | 1138288..1139523 | 1235 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 136 a.a. Molecular weight: 14464.55 Da Isoelectric Point: 4.6697
>T62806 WP_007168487.1 NZ_CP015272:c1137516-1137109 [Mycobacterium intracellulare subsp. chimaera]
VIYLDTSALVKLIRIEVESDALADWLDERTETRWITSALAEVELPRAIRAVAPNGLSAVPSVLARLDRFEIDQVIRATAA
AYPDPALRSLDAIHLATAQIAASTAPLTAMVAYDSRLSDAARALGITIVTPGRNS
VIYLDTSALVKLIRIEVESDALADWLDERTETRWITSALAEVELPRAIRAVAPNGLSAVPSVLARLDRFEIDQVIRATAA
AYPDPALRSLDAIHLATAQIAASTAPLTAMVAYDSRLSDAARALGITIVTPGRNS
Download Length: 408 bp
>T62806 NZ_CP015272:c1137516-1137109 [Mycobacterium intracellulare subsp. chimaera]
GTGATCTACCTGGATACCTCGGCTCTGGTCAAGCTGATCCGGATCGAAGTCGAATCTGATGCTCTAGCTGACTGGCTCGA
TGAACGCACCGAAACACGTTGGATAACATCTGCCTTGGCTGAAGTGGAGCTCCCCAGAGCCATCCGCGCAGTCGCCCCAA
ATGGCTTATCTGCTGTCCCCTCTGTGCTGGCCAGACTGGATCGGTTCGAAATCGACCAGGTCATCCGCGCCACCGCGGCC
GCCTACCCCGATCCGGCGCTGCGCTCGCTCGATGCGATACACCTGGCCACCGCTCAAATCGCCGCATCCACAGCACCATT
GACCGCCATGGTCGCCTATGACAGTCGACTCAGCGACGCCGCCCGTGCCCTCGGGATAACGATTGTCACACCTGGAAGAA
ACTCATGA
GTGATCTACCTGGATACCTCGGCTCTGGTCAAGCTGATCCGGATCGAAGTCGAATCTGATGCTCTAGCTGACTGGCTCGA
TGAACGCACCGAAACACGTTGGATAACATCTGCCTTGGCTGAAGTGGAGCTCCCCAGAGCCATCCGCGCAGTCGCCCCAA
ATGGCTTATCTGCTGTCCCCTCTGTGCTGGCCAGACTGGATCGGTTCGAAATCGACCAGGTCATCCGCGCCACCGCGGCC
GCCTACCCCGATCCGGCGCTGCGCTCGCTCGATGCGATACACCTGGCCACCGCTCAAATCGCCGCATCCACAGCACCATT
GACCGCCATGGTCGCCTATGACAGTCGACTCAGCGACGCCGCCCGTGCCCTCGGGATAACGATTGTCACACCTGGAAGAA
ACTCATGA
Antitoxin
Download Length: 91 a.a. Molecular weight: 9764.35 Da Isoelectric Point: 8.7382
>AT62806 WP_033711258.1 NZ_CP015272:c1137792-1137520 [Mycobacterium intracellulare subsp. chimaera]
MSEVPLRMLNQETAKVLARVKRGEEITLTERGEVIARIIPATAGPLDALITAGRVQPATLAGPAPRPTVPMHDNLDAGAL
LQRLRAEERY
MSEVPLRMLNQETAKVLARVKRGEEITLTERGEVIARIIPATAGPLDALITAGRVQPATLAGPAPRPTVPMHDNLDAGAL
LQRLRAEERY
Download Length: 273 bp
>AT62806 NZ_CP015272:c1137792-1137520 [Mycobacterium intracellulare subsp. chimaera]
ATGAGTGAAGTACCTCTCCGAATGCTCAACCAAGAGACGGCAAAGGTCTTGGCCCGCGTCAAGCGTGGCGAAGAGATCAC
GCTTACTGAGCGCGGGGAAGTCATCGCCCGAATAATCCCCGCTACCGCCGGCCCACTGGATGCGTTGATCACTGCCGGCA
GAGTGCAACCGGCGACGCTGGCCGGCCCAGCCCCGCGGCCGACCGTTCCGATGCACGACAATCTCGACGCCGGCGCGCTA
TTGCAACGTCTGCGCGCCGAGGAAAGGTATTAG
ATGAGTGAAGTACCTCTCCGAATGCTCAACCAAGAGACGGCAAAGGTCTTGGCCCGCGTCAAGCGTGGCGAAGAGATCAC
GCTTACTGAGCGCGGGGAAGTCATCGCCCGAATAATCCCCGCTACCGCCGGCCCACTGGATGCGTTGATCACTGCCGGCA
GAGTGCAACCGGCGACGCTGGCCGGCCCAGCCCCGCGGCCGACCGTTCCGATGCACGACAATCTCGACGCCGGCGCGCTA
TTGCAACGTCTGCGCGCCGAGGAAAGGTATTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1X1XAJ9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1X1XBB9 |