Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 1072155..1072822 Replicon chromosome
Accession NZ_CP015272
Organism Mycobacterium intracellulare subsp. chimaera strain ZUERICH-1

Toxin (Protein)


Gene name vapC Uniprot ID D5PE24
Locus tag MYCOZU1_RS05280 Protein ID WP_007168407.1
Coordinates 1072430..1072822 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID D5PE23
Locus tag MYCOZU1_RS05275 Protein ID WP_007168406.1
Coordinates 1072155..1072430 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MYCOZU1_RS30505 1067659..1067985 - 327 WP_033711234.1 hypothetical protein -
MYCOZU1_RS05250 1067975..1068208 - 234 Protein_1032 transposase -
MYCOZU1_RS05255 1068226..1069437 - 1212 Protein_1033 ISL3 family transposase -
MYCOZU1_RS05260 1069576..1070208 - 633 Protein_1034 DDE-type integrase/transposase/recombinase -
MYCOZU1_RS30015 1070160..1070300 - 141 WP_145958858.1 SDR family oxidoreductase -
MYCOZU1_RS05265 1070344..1071047 - 704 Protein_1036 histidine phosphatase family protein -
MYCOZU1_RS05270 1071130..1072002 + 873 WP_007168405.1 MaoC family dehydratase N-terminal domain-containing protein -
MYCOZU1_RS05275 1072155..1072430 + 276 WP_007168406.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MYCOZU1_RS05280 1072430..1072822 + 393 WP_007168407.1 type II toxin-antitoxin system VapC family toxin Toxin
MYCOZU1_RS05285 1072970..1074129 - 1160 Protein_1040 trehalose-phosphatase -
MYCOZU1_RS05290 1074171..1075509 - 1339 Protein_1041 DUF1298 domain-containing protein -
MYCOZU1_RS30020 1075771..1075893 - 123 Protein_1042 IS1595 family transposase -
MYCOZU1_RS05300 1076229..1077563 + 1335 Protein_1043 IS1182 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-119)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-45)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14305.73 Da        Isoelectric Point: 10.5032

>T62805 WP_007168407.1 NZ_CP015272:1072430-1072822 [Mycobacterium intracellulare subsp. chimaera]
MAAIYLDSSAIVKLAVREPESDALRRYLRTRLPRVSSALARTEVMRALLHKGESARRAGRRALASLDLLRIDNRLLDLAG
GLLPIELRTLDAIHLATAQRLGMDLGRLCTYDDRMRDAAEALGMAVIAPS

Download         Length: 393 bp

>T62805 NZ_CP015272:1072430-1072822 [Mycobacterium intracellulare subsp. chimaera]
ATGGCGGCCATCTACCTGGACTCGTCCGCAATCGTCAAGCTTGCAGTTCGTGAGCCAGAGTCGGATGCGCTGCGTCGCTA
CCTTCGCACCCGGCTGCCGCGGGTGTCGAGTGCCCTTGCGCGGACGGAGGTCATGCGGGCTCTGCTCCACAAGGGTGAAT
CAGCCCGAAGAGCCGGACGCCGGGCGCTCGCGAGCCTAGACCTACTACGCATCGACAACCGATTGCTCGATCTTGCTGGT
GGGCTGCTGCCAATCGAGCTACGCACCCTCGATGCAATTCACCTGGCGACTGCCCAGCGGCTCGGCATGGATCTTGGCCG
GTTGTGCACTTACGACGACCGCATGCGCGACGCCGCCGAGGCGCTCGGCATGGCAGTGATTGCCCCGTCTTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10150.63 Da        Isoelectric Point: 5.1881

>AT62805 WP_007168406.1 NZ_CP015272:1072155-1072430 [Mycobacterium intracellulare subsp. chimaera]
MSTVGVRELRQRASELLRRVEAGETIEITDRGRPIALLSPMPEGGPYQQMLASGGIERATLDFDDLPEPVRLKTGIELPS
VTLARLREHER

Download         Length: 276 bp

>AT62805 NZ_CP015272:1072155-1072430 [Mycobacterium intracellulare subsp. chimaera]
ATGTCTACGGTGGGCGTTCGTGAGCTGCGGCAGCGGGCCAGCGAACTCCTCCGTCGGGTCGAGGCCGGCGAGACGATCGA
GATCACCGACCGTGGTCGGCCTATCGCCCTTCTCTCGCCGATGCCGGAGGGCGGTCCGTACCAGCAGATGCTGGCAAGCG
GCGGGATCGAACGTGCGACGCTTGACTTTGATGACCTTCCCGAGCCGGTCCGACTCAAAACGGGTATCGAGCTGCCGTCC
GTGACGCTTGCGCGCCTGCGTGAGCACGAGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X1XV84

Antitoxin

Source ID Structure
AlphaFold DB A0A1X1XUZ3

References