Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 113301..113848 Replicon plasmid unnamed 1
Accession NZ_CP015268
Organism Mycobacterium intracellulare subsp. chimaera strain ZUERICH-2

Toxin (Protein)


Gene name relE Uniprot ID A0A7U5MRA3
Locus tag MYCOZU2_RS29265 Protein ID WP_052955269.1
Coordinates 113567..113848 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1X0K5A9
Locus tag MYCOZU2_RS29260 Protein ID WP_047322047.1
Coordinates 113301..113570 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MYCOZU2_RS29235 108446..109516 - 1071 WP_192579510.1 IS110 family transposase -
MYCOZU2_RS29240 109996..110921 + 926 Protein_101 class I SAM-dependent methyltransferase -
MYCOZU2_RS29245 110929..111162 + 234 WP_192579511.1 hypothetical protein -
MYCOZU2_RS29250 111936..112523 + 588 WP_047322045.1 hypothetical protein -
MYCOZU2_RS29255 112520..113185 + 666 WP_047322046.1 RES family NAD+ phosphorylase -
MYCOZU2_RS29260 113301..113570 + 270 WP_047322047.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MYCOZU2_RS29265 113567..113848 + 282 WP_052955269.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MYCOZU2_RS29270 114080..114937 + 858 WP_089152514.1 pentapeptide repeat-containing protein -
MYCOZU2_RS31025 115129..115362 - 234 WP_047322049.1 hypothetical protein -
MYCOZU2_RS29275 115451..115702 + 252 WP_089152515.1 hypothetical protein -
MYCOZU2_RS29280 115973..116632 - 660 WP_136245930.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - eccA5 / esxN 1..175972 175972
- flank IS/Tn - - 108446..109498 1052


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-90)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10672.31 Da        Isoelectric Point: 10.2981

>T62801 WP_052955269.1 NZ_CP015268:113567-113848 [Mycobacterium intracellulare subsp. chimaera]
VSCEEASWSVHFSPTAIRALDRLPLKVAKAIAEFITGTLPTDPNRLSKPLSFEFAGWRVARRGDYRVAFRILEDDRVLLI
GRIEHRAHIYRQP

Download         Length: 282 bp

>T62801 NZ_CP015268:113567-113848 [Mycobacterium intracellulare subsp. chimaera]
GTGAGCTGCGAAGAAGCGTCCTGGTCCGTTCACTTCTCGCCTACCGCGATCCGGGCACTCGACCGTCTACCGCTGAAAGT
CGCCAAAGCGATCGCCGAATTCATCACAGGCACACTGCCCACCGACCCGAACCGGCTATCCAAACCGTTGAGCTTCGAAT
TCGCTGGCTGGCGCGTCGCCCGGCGCGGCGATTACCGCGTCGCATTCCGGATTCTCGAAGACGACCGGGTCCTGTTGATC
GGTCGCATCGAGCACCGCGCACACATCTACCGCCAACCATGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9692.77 Da        Isoelectric Point: 4.6389

>AT62801 WP_047322047.1 NZ_CP015268:113301-113570 [Mycobacterium intracellulare subsp. chimaera]
MKNVPLSEAKDKLSALVDEADTTHEIIQITRHGRAAAVLMSADDLDSLNETLHALRTPGFAEDLAQADADYAAGNTVTGE
EIRRRYGLR

Download         Length: 270 bp

>AT62801 NZ_CP015268:113301-113570 [Mycobacterium intracellulare subsp. chimaera]
ATGAAGAACGTACCGCTCTCGGAGGCCAAGGACAAGCTCTCCGCGCTCGTCGACGAGGCCGACACCACCCACGAAATCAT
TCAGATCACCCGACACGGGCGCGCCGCCGCGGTCCTGATGTCTGCCGACGATCTGGATTCACTCAACGAGACGCTGCACG
CACTGCGAACACCCGGTTTTGCCGAAGACCTCGCGCAGGCCGATGCCGACTACGCTGCCGGCAATACCGTCACTGGCGAG
GAGATCCGCCGGCGATACGGACTCAGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U5MRA3

Antitoxin

Source ID Structure
AlphaFold DB A0A1X0K5A9

References