Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 33475..34160 Replicon plasmid unnamed 1
Accession NZ_CP015268
Organism Mycobacterium intracellulare subsp. chimaera strain ZUERICH-2

Toxin (Protein)


Gene name vapC Uniprot ID A0A1X0JS24
Locus tag MYCOZU2_RS28875 Protein ID WP_047324166.1
Coordinates 33744..34160 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1X0JR97
Locus tag MYCOZU2_RS28870 Protein ID WP_047324157.1
Coordinates 33475..33738 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MYCOZU2_RS28855 30060..30965 - 906 WP_139315451.1 C40 family peptidase -
MYCOZU2_RS28860 31174..31791 - 618 WP_085081455.1 transglycosylase SLT domain-containing protein -
MYCOZU2_RS28865 32394..33227 - 834 WP_074021485.1 hypothetical protein -
MYCOZU2_RS28870 33475..33738 + 264 WP_047324157.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MYCOZU2_RS28875 33744..34160 + 417 WP_047324166.1 type II toxin-antitoxin system VapC family toxin Toxin
MYCOZU2_RS31005 34680..37010 - 2331 WP_139315450.1 hypothetical protein -
MYCOZU2_RS28885 37680..37952 - 273 WP_142274731.1 hypothetical protein -
MYCOZU2_RS31410 38038..38181 - 144 WP_167384289.1 hypothetical protein -
MYCOZU2_RS28890 38187..38876 - 690 WP_047324298.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - eccA5 / esxN 1..175972 175972


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15046.00 Da        Isoelectric Point: 5.0924

>T62800 WP_047324166.1 NZ_CP015268:33744-34160 [Mycobacterium intracellulare subsp. chimaera]
VIIDSSALIALIQGEAPYTEQIAAALAGDRSPVMSTANAAECLIVLTSRHGATARTVFDRLRSEINLEFQPFTLEHAWIA
HRAYLQYGKGRHPAALNYGDTMAYATAKLAQEPLIAIGNDFAQTDLEFDGVIGYWPTH

Download         Length: 417 bp

>T62800 NZ_CP015268:33744-34160 [Mycobacterium intracellulare subsp. chimaera]
GTGATCATCGACTCGTCAGCCCTTATTGCCTTGATCCAAGGCGAAGCCCCCTACACCGAACAGATCGCGGCCGCCCTCGC
CGGCGACCGTAGCCCGGTCATGTCCACGGCGAACGCCGCCGAATGCCTCATCGTGCTCACCAGCCGCCACGGCGCCACAG
CCCGCACCGTCTTCGACCGCCTCCGGTCCGAAATCAACCTCGAATTCCAACCATTCACACTCGAGCACGCGTGGATCGCA
CATCGGGCCTACCTCCAGTACGGAAAGGGTCGCCACCCCGCCGCCCTCAACTACGGAGACACCATGGCATACGCCACCGC
CAAACTCGCGCAGGAACCACTCATTGCGATCGGCAATGACTTCGCCCAAACAGACCTTGAATTCGACGGCGTCATCGGCT
ACTGGCCGACACACTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9933.19 Da        Isoelectric Point: 4.8308

>AT62800 WP_047324157.1 NZ_CP015268:33475-33738 [Mycobacterium intracellulare subsp. chimaera]
MAFNVKDEEVIQFADELAARLHLPSRIDAIRYALRAQIEITQSRTGNRADELLDVLRTEIWPLLHDRSPISKTEREQALG
YNDATGV

Download         Length: 264 bp

>AT62800 NZ_CP015268:33475-33738 [Mycobacterium intracellulare subsp. chimaera]
ATGGCTTTCAATGTGAAAGACGAAGAGGTGATCCAATTCGCCGACGAGCTCGCCGCCCGCCTGCACCTCCCCAGCCGCAT
CGACGCAATCCGCTACGCACTGCGCGCCCAGATCGAGATCACCCAATCCCGCACGGGAAACCGCGCCGACGAACTGCTCG
ACGTCCTCAGAACCGAGATCTGGCCACTGCTGCACGACCGATCCCCTATCAGCAAGACCGAACGCGAACAAGCGCTCGGA
TACAACGACGCCACGGGCGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X0JS24

Antitoxin

Source ID Structure
AlphaFold DB A0A1X0JR97

References