Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Rv0298-Rv0299/- |
Location | 4567448..4567974 | Replicon | chromosome |
Accession | NZ_CP015267 | ||
Organism | Mycobacterium intracellulare subsp. chimaera strain ZUERICH-2 |
Toxin (Protein)
Gene name | Rv0299 | Uniprot ID | S4ZDZ6 |
Locus tag | MYCOZU2_RS21120 | Protein ID | WP_008259048.1 |
Coordinates | 4567672..4567974 (+) | Length | 101 a.a. |
Antitoxin (Protein)
Gene name | Rv0298 | Uniprot ID | S4ZFD0 |
Locus tag | MYCOZU2_RS21115 | Protein ID | WP_008259047.1 |
Coordinates | 4567448..4567675 (+) | Length | 76 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MYCOZU2_RS21090 | 4562519..4563445 | - | 927 | WP_042912749.1 | MinD/ParA family protein | - |
MYCOZU2_RS21095 | 4563690..4564721 | - | 1032 | WP_042912751.1 | 6-phosphofructokinase | - |
MYCOZU2_RS21100 | 4564765..4566258 | - | 1494 | WP_042912754.1 | Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA | - |
MYCOZU2_RS21105 | 4566255..4566554 | - | 300 | WP_009952003.1 | Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC | - |
MYCOZU2_RS21110 | 4566654..4567310 | + | 657 | WP_087139897.1 | amino acid-binding protein | - |
MYCOZU2_RS21115 | 4567448..4567675 | + | 228 | WP_008259047.1 | ribbon-helix-helix protein, CopG family | Antitoxin |
MYCOZU2_RS21120 | 4567672..4567974 | + | 303 | WP_008259048.1 | hypothetical protein | Toxin |
MYCOZU2_RS21125 | 4568090..4568398 | - | 309 | WP_008259049.1 | hypothetical protein | - |
MYCOZU2_RS21130 | 4568457..4571378 | - | 2922 | WP_014712101.1 | MMPL family transporter | - |
MYCOZU2_RS21135 | 4571375..4571779 | - | 405 | WP_008259052.1 | hypothetical protein | - |
MYCOZU2_RS21140 | 4572026..4572544 | + | 519 | WP_042912757.1 | pyridoxamine 5'-phosphate oxidase family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 10473.31 Da Isoelectric Point: 4.5636
>T62799 WP_008259048.1 NZ_CP015267:4567672-4567974 [Mycobacterium intracellulare subsp. chimaera]
MIAPGDIAPRRDTRRDLYVAVLSNAIHLAANTGRVIVCPFIPGKIPDDTMAMVVPLTQPEGTLLPELVQWLPTSALGEPI
GAVSAAALSEAMSIVTALIT
MIAPGDIAPRRDTRRDLYVAVLSNAIHLAANTGRVIVCPFIPGKIPDDTMAMVVPLTQPEGTLLPELVQWLPTSALGEPI
GAVSAAALSEAMSIVTALIT
Download Length: 303 bp
>T62799 NZ_CP015267:4567672-4567974 [Mycobacterium intracellulare subsp. chimaera]
ATGATCGCGCCGGGCGACATCGCGCCGCGGCGAGACACCCGCCGCGACCTCTACGTCGCGGTGCTCTCCAACGCGATCCA
CCTCGCGGCCAACACTGGTCGCGTCATCGTCTGCCCGTTCATCCCTGGGAAAATCCCCGACGACACGATGGCCATGGTCG
TTCCGCTCACGCAGCCCGAAGGCACTCTTCTCCCCGAACTGGTGCAGTGGCTGCCGACTTCGGCGCTCGGTGAACCGATC
GGGGCCGTGTCGGCGGCCGCGCTTAGCGAGGCGATGTCGATCGTGACCGCGCTGATCACGTAA
ATGATCGCGCCGGGCGACATCGCGCCGCGGCGAGACACCCGCCGCGACCTCTACGTCGCGGTGCTCTCCAACGCGATCCA
CCTCGCGGCCAACACTGGTCGCGTCATCGTCTGCCCGTTCATCCCTGGGAAAATCCCCGACGACACGATGGCCATGGTCG
TTCCGCTCACGCAGCCCGAAGGCACTCTTCTCCCCGAACTGGTGCAGTGGCTGCCGACTTCGGCGCTCGGTGAACCGATC
GGGGCCGTGTCGGCGGCCGCGCTTAGCGAGGCGATGTCGATCGTGACCGCGCTGATCACGTAA
Antitoxin
Download Length: 76 a.a. Molecular weight: 8173.14 Da Isoelectric Point: 6.4608
>AT62799 WP_008259047.1 NZ_CP015267:4567448-4567675 [Mycobacterium intracellulare subsp. chimaera]
MAKEKISVTVDAAVLADADSDAKAAGLNRSEMIERALRNEHLRRALHTYTTRTAPALNIDSYAGQVYEANRAADL
MAKEKISVTVDAAVLADADSDAKAAGLNRSEMIERALRNEHLRRALHTYTTRTAPALNIDSYAGQVYEANRAADL
Download Length: 228 bp
>AT62799 NZ_CP015267:4567448-4567675 [Mycobacterium intracellulare subsp. chimaera]
ATGGCCAAAGAGAAGATTTCTGTCACCGTCGACGCCGCCGTGCTCGCCGACGCCGACTCCGACGCCAAAGCGGCCGGACT
GAATCGCTCCGAGATGATCGAGCGGGCGCTGCGCAATGAGCATCTACGTCGCGCGCTTCATACCTATACGACGCGGACCG
CACCAGCGCTCAACATCGACTCCTACGCCGGGCAAGTGTATGAAGCCAACCGGGCCGCGGACCTATGA
ATGGCCAAAGAGAAGATTTCTGTCACCGTCGACGCCGCCGTGCTCGCCGACGCCGACTCCGACGCCAAAGCGGCCGGACT
GAATCGCTCCGAGATGATCGAGCGGGCGCTGCGCAATGAGCATCTACGTCGCGCGCTTCATACCTATACGACGCGGACCG
CACCAGCGCTCAACATCGACTCCTACGCCGGGCAAGTGTATGAAGCCAACCGGGCCGCGGACCTATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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