Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pezAT/zeta-ParD |
| Location | 2868201..2869193 | Replicon | chromosome |
| Accession | NZ_CP015267 | ||
| Organism | Mycobacterium intracellulare subsp. chimaera strain ZUERICH-2 | ||
Toxin (Protein)
| Gene name | pezT | Uniprot ID | A0A220XUE4 |
| Locus tag | MYCOZU2_RS13375 | Protein ID | WP_008256420.1 |
| Coordinates | 2868615..2869193 (+) | Length | 193 a.a. |
Antitoxin (Protein)
| Gene name | pezA | Uniprot ID | I2ADH5 |
| Locus tag | MYCOZU2_RS13370 | Protein ID | WP_008256419.1 |
| Coordinates | 2868201..2868590 (+) | Length | 130 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MYCOZU2_RS13350 | 2863352..2864020 | - | 669 | WP_179945108.1 | hypothetical protein | - |
| MYCOZU2_RS13355 | 2864100..2865617 | + | 1518 | WP_008256416.1 | carboxylesterase/lipase family protein | - |
| MYCOZU2_RS13360 | 2865636..2867639 | + | 2004 | WP_008256417.1 | phosphotransferase | - |
| MYCOZU2_RS13365 | 2867636..2868130 | + | 495 | WP_008256418.1 | gluconokinase | - |
| MYCOZU2_RS13370 | 2868201..2868590 | + | 390 | WP_008256419.1 | hypothetical protein | Antitoxin |
| MYCOZU2_RS13375 | 2868615..2869193 | + | 579 | WP_008256420.1 | zeta toxin family protein | Toxin |
| MYCOZU2_RS13380 | 2869213..2870280 | - | 1068 | WP_008256421.1 | DoxX family membrane protein | - |
| MYCOZU2_RS13385 | 2870376..2870936 | + | 561 | WP_008256422.1 | pyrazinamidase PncA | - |
| MYCOZU2_RS13390 | 2870936..2871736 | + | 801 | WP_036428851.1 | nuclear transport factor 2 family protein | - |
| MYCOZU2_RS13395 | 2871748..2872098 | - | 351 | WP_008256426.1 | DoxX family protein | - |
| MYCOZU2_RS13400 | 2872264..2873235 | + | 972 | WP_008256428.1 | sigma-70 family RNA polymerase sigma factor | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21054.10 Da Isoelectric Point: 10.5080
>T62798 WP_008256420.1 NZ_CP015267:2868615-2869193 [Mycobacterium intracellulare subsp. chimaera]
MQRLDLVVGPNGAGKSTFIAFTLAPLLPGSPVVNADEIARQRWPGESAGRAYEAAQIAADTRAKLIDLGRSFIAETVLSH
PSKLDLIRTAHRAGFTAVLHAMLIPEDLAVERVRHRVRAGGHDVPETKVRERHRRLWTPVTDAIALSDVATVYDNSRLRG
PRIVARLSGGMTIGSPDWPAWAPEILRSHWPD
MQRLDLVVGPNGAGKSTFIAFTLAPLLPGSPVVNADEIARQRWPGESAGRAYEAAQIAADTRAKLIDLGRSFIAETVLSH
PSKLDLIRTAHRAGFTAVLHAMLIPEDLAVERVRHRVRAGGHDVPETKVRERHRRLWTPVTDAIALSDVATVYDNSRLRG
PRIVARLSGGMTIGSPDWPAWAPEILRSHWPD
Download Length: 579 bp
>T62798 NZ_CP015267:2868615-2869193 [Mycobacterium intracellulare subsp. chimaera]
ATGCAGCGACTTGACCTGGTGGTCGGGCCGAACGGTGCCGGCAAGTCGACCTTCATCGCGTTCACCCTGGCGCCGCTGTT
GCCCGGCAGCCCGGTCGTCAACGCCGACGAAATCGCAAGGCAGCGCTGGCCGGGGGAGTCGGCGGGGCGCGCCTACGAGG
CCGCGCAAATCGCCGCCGACACGCGCGCGAAGTTGATCGACCTGGGGCGGTCGTTTATCGCGGAGACCGTGCTTTCCCAC
CCGTCGAAGCTGGACCTCATCCGCACCGCCCACCGAGCGGGCTTCACCGCCGTCCTGCACGCGATGCTCATCCCGGAAGA
CCTTGCCGTCGAACGTGTCCGGCACCGCGTGCGGGCCGGCGGCCACGACGTACCGGAAACCAAGGTTCGCGAGCGCCATC
GTCGCTTGTGGACACCGGTCACCGACGCCATCGCGCTTTCCGACGTCGCCACCGTCTACGACAACAGCCGGCTGCGCGGG
CCGCGCATTGTCGCCCGCCTCAGCGGCGGCATGACGATCGGTTCACCGGACTGGCCGGCGTGGGCTCCGGAGATCTTGCG
GTCACACTGGCCGGACTAG
ATGCAGCGACTTGACCTGGTGGTCGGGCCGAACGGTGCCGGCAAGTCGACCTTCATCGCGTTCACCCTGGCGCCGCTGTT
GCCCGGCAGCCCGGTCGTCAACGCCGACGAAATCGCAAGGCAGCGCTGGCCGGGGGAGTCGGCGGGGCGCGCCTACGAGG
CCGCGCAAATCGCCGCCGACACGCGCGCGAAGTTGATCGACCTGGGGCGGTCGTTTATCGCGGAGACCGTGCTTTCCCAC
CCGTCGAAGCTGGACCTCATCCGCACCGCCCACCGAGCGGGCTTCACCGCCGTCCTGCACGCGATGCTCATCCCGGAAGA
CCTTGCCGTCGAACGTGTCCGGCACCGCGTGCGGGCCGGCGGCCACGACGTACCGGAAACCAAGGTTCGCGAGCGCCATC
GTCGCTTGTGGACACCGGTCACCGACGCCATCGCGCTTTCCGACGTCGCCACCGTCTACGACAACAGCCGGCTGCGCGGG
CCGCGCATTGTCGCCCGCCTCAGCGGCGGCATGACGATCGGTTCACCGGACTGGCCGGCGTGGGCTCCGGAGATCTTGCG
GTCACACTGGCCGGACTAG
Antitoxin
Download Length: 130 a.a. Molecular weight: 13518.97 Da Isoelectric Point: 5.1668
>AT62798 WP_008256419.1 NZ_CP015267:2868201-2868590 [Mycobacterium intracellulare subsp. chimaera]
MADAPDRVTRVASDLMDSAASEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAAMAGQLATGELTVEEGVVFNAEI
SAAIEESLVHANYGATLAGHGVTTVALNEDGDIVEHLPDGAAVMLARGR
MADAPDRVTRVASDLMDSAASEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAAMAGQLATGELTVEEGVVFNAEI
SAAIEESLVHANYGATLAGHGVTTVALNEDGDIVEHLPDGAAVMLARGR
Download Length: 390 bp
>AT62798 NZ_CP015267:2868201-2868590 [Mycobacterium intracellulare subsp. chimaera]
ATGGCCGACGCTCCCGATCGTGTGACCCGGGTGGCGTCCGACCTGATGGACAGCGCGGCCTCCGAAGGCGCCCGCCAGAG
CCGTTCGGCCAAGCAGCAACTCGACCACTGGGCGCGTGTCGGGCGCGCGGTGTCCAGCCAGCACACCGCCTCGCGTCGGC
GGGTCGAGGCCGCGATGGCCGGCCAGCTGGCGACCGGCGAACTCACCGTCGAGGAAGGCGTGGTGTTCAACGCCGAGATC
TCCGCGGCTATTGAAGAAAGCCTGGTGCACGCCAACTACGGGGCGACGCTGGCCGGGCATGGGGTCACCACGGTCGCCCT
CAACGAGGACGGCGACATCGTCGAGCACCTGCCCGATGGCGCCGCCGTAATGCTGGCGCGCGGGCGCTGA
ATGGCCGACGCTCCCGATCGTGTGACCCGGGTGGCGTCCGACCTGATGGACAGCGCGGCCTCCGAAGGCGCCCGCCAGAG
CCGTTCGGCCAAGCAGCAACTCGACCACTGGGCGCGTGTCGGGCGCGCGGTGTCCAGCCAGCACACCGCCTCGCGTCGGC
GGGTCGAGGCCGCGATGGCCGGCCAGCTGGCGACCGGCGAACTCACCGTCGAGGAAGGCGTGGTGTTCAACGCCGAGATC
TCCGCGGCTATTGAAGAAAGCCTGGTGCACGCCAACTACGGGGCGACGCTGGCCGGGCATGGGGTCACCACGGTCGCCCT
CAACGAGGACGGCGACATCGTCGAGCACCTGCCCGATGGCGCCGCCGTAATGCTGGCGCGCGGGCGCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A220XUE4 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | I2ADH5 |